| Full name: selectin E | Alias Symbol: ESEL|CD62E | ||
| Type: protein-coding gene | Cytoband: 1q24.2 | ||
| Entrez ID: 6401 | HGNC ID: HGNC:10718 | Ensembl Gene: ENSG00000007908 | OMIM ID: 131210 |
| Drug and gene relationship at DGIdb | |||
SELE involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
Expression of SELE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SELE | 6401 | 206211_at | -0.4054 | 0.9069 | |
| GSE20347 | SELE | 6401 | 206211_at | 0.0453 | 0.9011 | |
| GSE23400 | SELE | 6401 | 206211_at | 0.2095 | 0.1070 | |
| GSE26886 | SELE | 6401 | 206211_at | 0.0179 | 0.9738 | |
| GSE29001 | SELE | 6401 | 206211_at | 0.5115 | 0.1716 | |
| GSE38129 | SELE | 6401 | 206211_at | 0.1476 | 0.7754 | |
| GSE45670 | SELE | 6401 | 206211_at | -1.1051 | 0.2507 | |
| GSE53622 | SELE | 6401 | 128723 | 0.2845 | 0.3741 | |
| GSE53624 | SELE | 6401 | 52243 | 0.1779 | 0.5132 | |
| GSE63941 | SELE | 6401 | 206211_at | 0.0058 | 0.9739 | |
| GSE77861 | SELE | 6401 | 206211_at | 0.7196 | 0.1561 | |
| GSE97050 | SELE | 6401 | A_33_P3421053 | 0.3330 | 0.7841 | |
| SRP007169 | SELE | 6401 | RNAseq | 1.9308 | 0.0031 | |
| SRP064894 | SELE | 6401 | RNAseq | 0.6166 | 0.2980 | |
| SRP133303 | SELE | 6401 | RNAseq | 1.4723 | 0.0082 | |
| SRP159526 | SELE | 6401 | RNAseq | 3.2324 | 0.0000 | |
| TCGA | SELE | 6401 | RNAseq | 0.4761 | 0.1922 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SELE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SELE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SELE | 6401 | 12 | 1 | 17 | |
| GSE20123 | SELE | 6401 | 12 | 1 | 17 | |
| GSE43470 | SELE | 6401 | 7 | 2 | 34 | |
| GSE46452 | SELE | 6401 | 3 | 1 | 55 | |
| GSE47630 | SELE | 6401 | 14 | 0 | 26 | |
| GSE54993 | SELE | 6401 | 0 | 6 | 64 | |
| GSE54994 | SELE | 6401 | 16 | 0 | 37 | |
| GSE60625 | SELE | 6401 | 0 | 0 | 11 | |
| GSE74703 | SELE | 6401 | 7 | 2 | 27 | |
| GSE74704 | SELE | 6401 | 6 | 0 | 14 | |
| TCGA | SELE | 6401 | 43 | 3 | 50 |
Total number of gains: 120; Total number of losses: 16; Total Number of normals: 352.
Somatic mutations of SELE:
Generating mutation plots.
Highly correlated genes for SELE:
Showing top 20/149 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SELE | NFKBID | 0.810423 | 3 | 0 | 3 |
| SELE | FAM50A | 0.717066 | 3 | 0 | 3 |
| SELE | NPC1 | 0.704946 | 3 | 0 | 3 |
| SELE | HEXB | 0.701944 | 3 | 0 | 3 |
| SELE | RFX5 | 0.69681 | 3 | 0 | 3 |
| SELE | C1orf115 | 0.681876 | 3 | 0 | 3 |
| SELE | RND1 | 0.677602 | 4 | 0 | 4 |
| SELE | PRR5L | 0.663902 | 3 | 0 | 3 |
| SELE | SGCG | 0.661925 | 3 | 0 | 3 |
| SELE | VPS72 | 0.648051 | 3 | 0 | 3 |
| SELE | SLC39A1 | 0.647452 | 4 | 0 | 3 |
| SELE | SHANK3 | 0.639873 | 4 | 0 | 4 |
| SELE | CHD1L | 0.638871 | 3 | 0 | 3 |
| SELE | ASAP1 | 0.638752 | 3 | 0 | 3 |
| SELE | GPR3 | 0.635266 | 3 | 0 | 3 |
| SELE | TM4SF18 | 0.631929 | 4 | 0 | 3 |
| SELE | ANKRD10 | 0.630453 | 4 | 0 | 3 |
| SELE | CCL2 | 0.625533 | 12 | 0 | 9 |
| SELE | NT5E | 0.624533 | 4 | 0 | 3 |
| SELE | SIRT2 | 0.62186 | 3 | 0 | 3 |
For details and further investigation, click here
