NPC1

 

Full name: NPC intracellular cholesterol transporter 1 Alias Symbol: SLC65A1
Type: protein-coding gene Cytoband: 18q11.2
Entrez ID: 4864 HGNC ID: HGNC:7897 Ensembl Gene: ENSG00000141458 OMIM ID: 607623
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of NPC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NPC1 4864 202679_at 0.1133 0.8774
GSE20347 NPC1 4864 202679_at -0.0386 0.8525
GSE23400 NPC1 4864 202679_at 0.1812 0.0520
GSE26886 NPC1 4864 202679_at -0.6441 0.0004
GSE29001 NPC1 4864 202679_at -0.2336 0.5025
GSE38129 NPC1 4864 202679_at 0.2756 0.1161
GSE45670 NPC1 4864 202679_at 0.3669 0.0461
GSE53622 NPC1 4864 75547 0.3750 0.0000
GSE53624 NPC1 4864 75547 0.3337 0.0000
GSE63941 NPC1 4864 202679_at -0.9750 0.0632
GSE77861 NPC1 4864 202679_at 0.5959 0.0257
GSE97050 NPC1 4864 A_23_P107587 0.5567 0.1623
SRP007169 NPC1 4864 RNAseq 0.9482 0.0232
SRP008496 NPC1 4864 RNAseq 0.6876 0.0136
SRP064894 NPC1 4864 RNAseq -0.0600 0.8099
SRP133303 NPC1 4864 RNAseq 0.4406 0.0338
SRP159526 NPC1 4864 RNAseq 0.2693 0.4843
SRP193095 NPC1 4864 RNAseq 0.2166 0.1124
SRP219564 NPC1 4864 RNAseq 0.2344 0.5731
TCGA NPC1 4864 RNAseq -0.0143 0.7862

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NPC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NPC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NPC1 4864 2 5 23
GSE20123 NPC1 4864 1 5 24
GSE43470 NPC1 4864 2 1 40
GSE46452 NPC1 4864 3 23 33
GSE47630 NPC1 4864 7 18 15
GSE54993 NPC1 4864 7 1 62
GSE54994 NPC1 4864 4 12 37
GSE60625 NPC1 4864 0 4 7
GSE74703 NPC1 4864 2 1 33
GSE74704 NPC1 4864 1 4 15
TCGA NPC1 4864 14 25 57

Total number of gains: 43; Total number of losses: 99; Total Number of normals: 346.  

 

Somatic mutations of NPC1:

 

Generating mutation plots.

 

Highly correlated genes for NPC1:

 

Showing top 20/136 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NPC1MLKL0.756553303
NPC1PRDM100.738038303
NPC1PTPRE0.706385303
NPC1SELE0.704946303
NPC1AGPAT50.697504303
NPC1ZBED60.684439303
NPC1GSDMC0.678166303
NPC1ALDH1A30.676998303
NPC1AKIRIN20.674095504
NPC1CRIPT0.671758303
NPC1THAP20.664433303
NPC1GAN0.660019303
NPC1RAB2A0.659565403
NPC1ALAS10.652975403
NPC1TBC1D200.648893303
NPC1WDR590.648388404
NPC1SRRD0.644423403
NPC1ARHGAP170.642536403
NPC1CXCL50.639673403
NPC1NPAS20.638634404

For details and further investigation, click here