| Full name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | Alias Symbol: ATPSK2 | ||
| Type: protein-coding gene | Cytoband: 10q23.2-q23.31 | ||
| Entrez ID: 9060 | HGNC ID: HGNC:8604 | Ensembl Gene: ENSG00000198682 | OMIM ID: 603005 |
| Drug and gene relationship at DGIdb | |||
Expression of PAPSS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAPSS2 | 9060 | 203060_s_at | -0.4806 | 0.6187 | |
| GSE20347 | PAPSS2 | 9060 | 203060_s_at | 0.6273 | 0.0387 | |
| GSE23400 | PAPSS2 | 9060 | 203060_s_at | 0.0950 | 0.4378 | |
| GSE26886 | PAPSS2 | 9060 | 203060_s_at | 0.0338 | 0.9685 | |
| GSE29001 | PAPSS2 | 9060 | 203060_s_at | 0.2804 | 0.6536 | |
| GSE38129 | PAPSS2 | 9060 | 203060_s_at | 0.3993 | 0.1377 | |
| GSE45670 | PAPSS2 | 9060 | 203060_s_at | -0.3558 | 0.4199 | |
| GSE53622 | PAPSS2 | 9060 | 93686 | 0.3279 | 0.0898 | |
| GSE53624 | PAPSS2 | 9060 | 93686 | 0.0825 | 0.6531 | |
| GSE63941 | PAPSS2 | 9060 | 203060_s_at | -5.4344 | 0.0055 | |
| GSE77861 | PAPSS2 | 9060 | 203060_s_at | -0.4862 | 0.3038 | |
| GSE97050 | PAPSS2 | 9060 | A_24_P940166 | 0.5947 | 0.1721 | |
| SRP007169 | PAPSS2 | 9060 | RNAseq | 0.7838 | 0.2173 | |
| SRP008496 | PAPSS2 | 9060 | RNAseq | 0.1160 | 0.7775 | |
| SRP064894 | PAPSS2 | 9060 | RNAseq | -0.3450 | 0.3531 | |
| SRP133303 | PAPSS2 | 9060 | RNAseq | -0.1909 | 0.6012 | |
| SRP159526 | PAPSS2 | 9060 | RNAseq | -0.2996 | 0.3548 | |
| SRP193095 | PAPSS2 | 9060 | RNAseq | -0.3108 | 0.2677 | |
| SRP219564 | PAPSS2 | 9060 | RNAseq | 0.8616 | 0.0512 | |
| TCGA | PAPSS2 | 9060 | RNAseq | -0.2049 | 0.0678 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PAPSS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAPSS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAPSS2 | 9060 | 2 | 7 | 21 | |
| GSE20123 | PAPSS2 | 9060 | 2 | 6 | 22 | |
| GSE43470 | PAPSS2 | 9060 | 0 | 9 | 34 | |
| GSE46452 | PAPSS2 | 9060 | 0 | 11 | 48 | |
| GSE47630 | PAPSS2 | 9060 | 2 | 14 | 24 | |
| GSE54993 | PAPSS2 | 9060 | 7 | 0 | 63 | |
| GSE54994 | PAPSS2 | 9060 | 1 | 11 | 41 | |
| GSE60625 | PAPSS2 | 9060 | 0 | 0 | 11 | |
| GSE74703 | PAPSS2 | 9060 | 0 | 7 | 29 | |
| GSE74704 | PAPSS2 | 9060 | 1 | 4 | 15 | |
| TCGA | PAPSS2 | 9060 | 6 | 28 | 62 |
Total number of gains: 21; Total number of losses: 97; Total Number of normals: 370.
Somatic mutations of PAPSS2:
Generating mutation plots.
Highly correlated genes for PAPSS2:
Showing top 20/412 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAPSS2 | CABLES1 | 0.789607 | 3 | 0 | 3 |
| PAPSS2 | NAT1 | 0.734444 | 3 | 0 | 3 |
| PAPSS2 | SSR1 | 0.732213 | 3 | 0 | 3 |
| PAPSS2 | SEMA6A | 0.72682 | 3 | 0 | 3 |
| PAPSS2 | CHM | 0.724872 | 3 | 0 | 3 |
| PAPSS2 | CLEC2D | 0.721011 | 3 | 0 | 3 |
| PAPSS2 | QSOX1 | 0.719881 | 3 | 0 | 3 |
| PAPSS2 | GNGT2 | 0.712444 | 3 | 0 | 3 |
| PAPSS2 | MBNL3 | 0.710024 | 3 | 0 | 3 |
| PAPSS2 | LYRM2 | 0.698038 | 3 | 0 | 3 |
| PAPSS2 | TTC39C | 0.693489 | 3 | 0 | 3 |
| PAPSS2 | JAK2 | 0.692192 | 3 | 0 | 3 |
| PAPSS2 | NDUFS4 | 0.689561 | 3 | 0 | 3 |
| PAPSS2 | STXBP5 | 0.688178 | 3 | 0 | 3 |
| PAPSS2 | SMPD1 | 0.684054 | 4 | 0 | 3 |
| PAPSS2 | ANKHD1 | 0.683706 | 3 | 0 | 3 |
| PAPSS2 | IGFBP5 | 0.683506 | 4 | 0 | 3 |
| PAPSS2 | RHOH | 0.683317 | 4 | 0 | 3 |
| PAPSS2 | SAMD9L | 0.680659 | 3 | 0 | 3 |
| PAPSS2 | CYB5A | 0.677836 | 3 | 0 | 3 |
For details and further investigation, click here
