| Full name: serpin family E member 2 | Alias Symbol: PN1|GDN|PNI|nexin | ||
| Type: protein-coding gene | Cytoband: 2q36.1 | ||
| Entrez ID: 5270 | HGNC ID: HGNC:8951 | Ensembl Gene: ENSG00000135919 | OMIM ID: 177010 |
| Drug and gene relationship at DGIdb | |||
Expression of SERPINE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINE2 | 5270 | 212190_at | -0.7131 | 0.3470 | |
| GSE20347 | SERPINE2 | 5270 | 212190_at | 0.0762 | 0.8527 | |
| GSE23400 | SERPINE2 | 5270 | 212190_at | 0.5919 | 0.0034 | |
| GSE26886 | SERPINE2 | 5270 | 212190_at | 0.8780 | 0.1318 | |
| GSE29001 | SERPINE2 | 5270 | 212190_at | -0.0507 | 0.9525 | |
| GSE38129 | SERPINE2 | 5270 | 212190_at | 0.2338 | 0.4310 | |
| GSE45670 | SERPINE2 | 5270 | 212190_at | -0.1290 | 0.8291 | |
| GSE53622 | SERPINE2 | 5270 | 50099 | 0.0640 | 0.7742 | |
| GSE53624 | SERPINE2 | 5270 | 50099 | 0.0058 | 0.9723 | |
| GSE63941 | SERPINE2 | 5270 | 212190_at | -4.0544 | 0.0027 | |
| GSE77861 | SERPINE2 | 5270 | 212190_at | 0.9945 | 0.1212 | |
| GSE97050 | SERPINE2 | 5270 | A_23_P50919 | 0.6650 | 0.2261 | |
| SRP007169 | SERPINE2 | 5270 | RNAseq | 1.6864 | 0.0025 | |
| SRP008496 | SERPINE2 | 5270 | RNAseq | 2.0387 | 0.0000 | |
| SRP064894 | SERPINE2 | 5270 | RNAseq | 0.6536 | 0.0539 | |
| SRP133303 | SERPINE2 | 5270 | RNAseq | 0.4757 | 0.2857 | |
| SRP159526 | SERPINE2 | 5270 | RNAseq | 0.6164 | 0.2633 | |
| SRP193095 | SERPINE2 | 5270 | RNAseq | 0.8629 | 0.0102 | |
| SRP219564 | SERPINE2 | 5270 | RNAseq | 1.0794 | 0.1236 | |
| TCGA | SERPINE2 | 5270 | RNAseq | 0.4887 | 0.0005 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by SERPINE2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINE2 | 5270 | 2 | 12 | 16 | |
| GSE20123 | SERPINE2 | 5270 | 2 | 12 | 16 | |
| GSE43470 | SERPINE2 | 5270 | 0 | 7 | 36 | |
| GSE46452 | SERPINE2 | 5270 | 0 | 5 | 54 | |
| GSE47630 | SERPINE2 | 5270 | 4 | 5 | 31 | |
| GSE54993 | SERPINE2 | 5270 | 1 | 2 | 67 | |
| GSE54994 | SERPINE2 | 5270 | 7 | 10 | 36 | |
| GSE60625 | SERPINE2 | 5270 | 3 | 0 | 8 | |
| GSE74703 | SERPINE2 | 5270 | 0 | 6 | 30 | |
| GSE74704 | SERPINE2 | 5270 | 2 | 6 | 12 | |
| TCGA | SERPINE2 | 5270 | 13 | 27 | 56 |
Total number of gains: 34; Total number of losses: 92; Total Number of normals: 362.
Somatic mutations of SERPINE2:
Generating mutation plots.
Highly correlated genes for SERPINE2:
Showing top 20/88 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINE2 | DOCK11 | 0.663523 | 4 | 0 | 4 |
| SERPINE2 | PLBD2 | 0.661698 | 3 | 0 | 3 |
| SERPINE2 | ITGA4 | 0.659736 | 3 | 0 | 3 |
| SERPINE2 | BEND6 | 0.638906 | 3 | 0 | 3 |
| SERPINE2 | FZD7 | 0.617206 | 4 | 0 | 3 |
| SERPINE2 | UBR1 | 0.616848 | 4 | 0 | 3 |
| SERPINE2 | COL8A1 | 0.599849 | 4 | 0 | 3 |
| SERPINE2 | KLF7 | 0.595704 | 5 | 0 | 3 |
| SERPINE2 | TENM2 | 0.593234 | 4 | 0 | 3 |
| SERPINE2 | GRIK2 | 0.59253 | 3 | 0 | 3 |
| SERPINE2 | CREB3L1 | 0.592442 | 3 | 0 | 3 |
| SERPINE2 | TMEM231 | 0.586431 | 4 | 0 | 4 |
| SERPINE2 | PPP1R12A | 0.584656 | 3 | 0 | 3 |
| SERPINE2 | MAMLD1 | 0.584552 | 3 | 0 | 3 |
| SERPINE2 | PEAR1 | 0.580639 | 5 | 0 | 3 |
| SERPINE2 | MSANTD3 | 0.579034 | 4 | 0 | 3 |
| SERPINE2 | L3HYPDH | 0.578067 | 4 | 0 | 3 |
| SERPINE2 | DCBLD1 | 0.574702 | 4 | 0 | 3 |
| SERPINE2 | FAM20C | 0.572473 | 3 | 0 | 3 |
| SERPINE2 | CD276 | 0.572328 | 5 | 0 | 3 |
For details and further investigation, click here
