| Full name: adenylate kinase 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 205 | HGNC ID: HGNC:363 | Ensembl Gene: ENSG00000162433 | OMIM ID: 103030 |
Screen Evidence:
| |||
Expression of AK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AK4 | 205 | 225342_at | -0.7804 | 0.3824 | |
| GSE20347 | AK4 | 205 | 204348_s_at | -0.4418 | 0.1051 | |
| GSE23400 | AK4 | 205 | 204348_s_at | -0.1156 | 0.2533 | |
| GSE26886 | AK4 | 205 | 225342_at | -1.6210 | 0.0008 | |
| GSE29001 | AK4 | 205 | 204348_s_at | -0.5263 | 0.1328 | |
| GSE38129 | AK4 | 205 | 204348_s_at | -0.2774 | 0.3257 | |
| GSE45670 | AK4 | 205 | 225342_at | -0.4360 | 0.0683 | |
| GSE53622 | AK4 | 205 | 52962 | -0.7198 | 0.0000 | |
| GSE53624 | AK4 | 205 | 52962 | -0.5928 | 0.0000 | |
| GSE63941 | AK4 | 205 | 204348_s_at | 1.8905 | 0.0079 | |
| GSE77861 | AK4 | 205 | 225342_at | -0.8713 | 0.0873 | |
| GSE97050 | AK4 | 205 | A_32_P108655 | -0.7279 | 0.1247 | |
| SRP007169 | AK4 | 205 | RNAseq | -0.9611 | 0.0026 | |
| SRP008496 | AK4 | 205 | RNAseq | -1.0530 | 0.0000 | |
| SRP064894 | AK4 | 205 | RNAseq | -0.3134 | 0.0877 | |
| SRP133303 | AK4 | 205 | RNAseq | -0.1772 | 0.4673 | |
| SRP159526 | AK4 | 205 | RNAseq | -1.1534 | 0.0063 | |
| SRP193095 | AK4 | 205 | RNAseq | -0.9037 | 0.0000 | |
| SRP219564 | AK4 | 205 | RNAseq | -0.7727 | 0.0157 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by AK4 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of AK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AK4 | 205 | 3 | 6 | 21 | |
| GSE20123 | AK4 | 205 | 3 | 5 | 22 | |
| GSE43470 | AK4 | 205 | 4 | 4 | 35 | |
| GSE46452 | AK4 | 205 | 0 | 1 | 58 | |
| GSE47630 | AK4 | 205 | 8 | 5 | 27 | |
| GSE54993 | AK4 | 205 | 0 | 0 | 70 | |
| GSE54994 | AK4 | 205 | 6 | 4 | 43 | |
| GSE60625 | AK4 | 205 | 0 | 0 | 11 | |
| GSE74703 | AK4 | 205 | 3 | 3 | 30 | |
| GSE74704 | AK4 | 205 | 2 | 2 | 16 | |
| TCGA | AK4 | 205 | 9 | 21 | 66 |
Total number of gains: 38; Total number of losses: 51; Total Number of normals: 399.
Somatic mutations of AK4:
Generating mutation plots.
Highly correlated genes for AK4:
Showing top 20/540 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AK4 | RPS23 | 0.838068 | 3 | 0 | 3 |
| AK4 | GTF3C6 | 0.735513 | 4 | 0 | 4 |
| AK4 | PAAF1 | 0.729435 | 3 | 0 | 3 |
| AK4 | NOL3 | 0.722959 | 3 | 0 | 3 |
| AK4 | GPCPD1 | 0.709976 | 3 | 0 | 3 |
| AK4 | GFM2 | 0.709133 | 3 | 0 | 3 |
| AK4 | VTI1B | 0.707317 | 5 | 0 | 4 |
| AK4 | PRPF38A | 0.707274 | 4 | 0 | 4 |
| AK4 | TMEM186 | 0.703744 | 3 | 0 | 3 |
| AK4 | CLMN | 0.698168 | 3 | 0 | 3 |
| AK4 | SETD2 | 0.697227 | 3 | 0 | 3 |
| AK4 | UBE2V2 | 0.693088 | 3 | 0 | 3 |
| AK4 | NDUFAF2 | 0.690475 | 4 | 0 | 3 |
| AK4 | TRAPPC6B | 0.680122 | 3 | 0 | 3 |
| AK4 | ERP44 | 0.67608 | 4 | 0 | 3 |
| AK4 | AK2 | 0.675961 | 4 | 0 | 3 |
| AK4 | TC2N | 0.675527 | 5 | 0 | 5 |
| AK4 | SPRYD4 | 0.67218 | 4 | 0 | 4 |
| AK4 | ATG2B | 0.670007 | 4 | 0 | 4 |
| AK4 | CSNK1A1 | 0.668216 | 6 | 0 | 5 |
For details and further investigation, click here
