SF3B1

 

Full name: splicing factor 3b subunit 1 Alias Symbol: SAP155|SF3b155|PRPF10|Prp10|Hsh155
Type: protein-coding gene Cytoband: 2q33.1
Entrez ID: 23451 HGNC ID: HGNC:10768 Ensembl Gene: ENSG00000115524 OMIM ID: 605590
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 204/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SF3B1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SF3B1 23451 201071_x_at 0.0340 0.9082
GSE20347 SF3B1 23451 211185_s_at 0.2200 0.1119
GSE23400 SF3B1 23451 201071_x_at 0.3320 0.0000
GSE26886 SF3B1 23451 211185_s_at 0.2586 0.0989
GSE29001 SF3B1 23451 211185_s_at -0.0827 0.7767
GSE38129 SF3B1 23451 211185_s_at 0.3289 0.0051
GSE45670 SF3B1 23451 211185_s_at 0.0367 0.8046
GSE53622 SF3B1 23451 72857 0.2828 0.0000
GSE53624 SF3B1 23451 72857 0.3136 0.0000
GSE63941 SF3B1 23451 211185_s_at 0.0213 0.9353
GSE77861 SF3B1 23451 211185_s_at 0.2195 0.1077
GSE97050 SF3B1 23451 A_23_P368393 0.2195 0.3270
SRP007169 SF3B1 23451 RNAseq 1.0671 0.0046
SRP008496 SF3B1 23451 RNAseq 1.2158 0.0000
SRP064894 SF3B1 23451 RNAseq -0.2419 0.3614
SRP133303 SF3B1 23451 RNAseq -0.0112 0.9256
SRP159526 SF3B1 23451 RNAseq -0.4164 0.0223
SRP193095 SF3B1 23451 RNAseq -0.0725 0.4830
SRP219564 SF3B1 23451 RNAseq -0.5469 0.1466
TCGA SF3B1 23451 RNAseq -0.0244 0.5147

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by SF3B1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SF3B1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SF3B1 23451 10 2 18
GSE20123 SF3B1 23451 10 2 18
GSE43470 SF3B1 23451 3 1 39
GSE46452 SF3B1 23451 1 4 54
GSE47630 SF3B1 23451 4 5 31
GSE54993 SF3B1 23451 0 3 67
GSE54994 SF3B1 23451 11 8 34
GSE60625 SF3B1 23451 0 3 8
GSE74703 SF3B1 23451 2 1 33
GSE74704 SF3B1 23451 5 2 13
TCGA SF3B1 23451 22 9 65

Total number of gains: 68; Total number of losses: 40; Total Number of normals: 380.  

 

Somatic mutations of SF3B1:

 

Generating mutation plots.

 

Highly correlated genes for SF3B1:

 

Showing top 20/162 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SF3B1FAM91A10.713269303
SF3B1CYTIP0.690463303
SF3B1VAV10.656469303
SF3B1GTF3C30.65471212011
SF3B1PLA2G70.64081303
SF3B1DYNC2LI10.639207303
SF3B1TIMM17A0.63786403
SF3B1VMA210.632462303
SF3B1SRGN0.61465303
SF3B1NSUN20.610089403
SF3B1MDM40.603047503
SF3B1RAD54L0.601786403
SF3B1CCR10.592669303
SF3B1UBXN40.590625403
SF3B1PGAP10.5889171008
SF3B1TTL0.587582404
SF3B1SUMO10.587104806
SF3B1PMPCB0.586613404
SF3B1ZBTB260.586002303
SF3B1KPNA20.585801403

For details and further investigation, click here