| Full name: karyopherin subunit alpha 2 | Alias Symbol: SRP1alpha|IPOA1|QIP2 | ||
| Type: protein-coding gene | Cytoband: 17q24.2 | ||
| Entrez ID: 3838 | HGNC ID: HGNC:6395 | Ensembl Gene: ENSG00000182481 | OMIM ID: 600685 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KPNA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KPNA2 | 3838 | 201088_at | 0.8970 | 0.0748 | |
| GSE20347 | KPNA2 | 3838 | 201088_at | 1.0908 | 0.0000 | |
| GSE23400 | KPNA2 | 3838 | 201088_at | 1.0373 | 0.0000 | |
| GSE26886 | KPNA2 | 3838 | 201088_at | 0.3956 | 0.0542 | |
| GSE29001 | KPNA2 | 3838 | 201088_at | 0.3844 | 0.0074 | |
| GSE38129 | KPNA2 | 3838 | 201088_at | 1.3362 | 0.0000 | |
| GSE45670 | KPNA2 | 3838 | 201088_at | 0.8256 | 0.0000 | |
| GSE63941 | KPNA2 | 3838 | 211762_s_at | 1.3369 | 0.0050 | |
| GSE77861 | KPNA2 | 3838 | 201088_at | 0.9054 | 0.0019 | |
| GSE97050 | KPNA2 | 3838 | A_23_P125265 | 0.8614 | 0.1801 | |
| SRP007169 | KPNA2 | 3838 | RNAseq | 2.4899 | 0.0000 | |
| SRP008496 | KPNA2 | 3838 | RNAseq | 1.8870 | 0.0000 | |
| SRP064894 | KPNA2 | 3838 | RNAseq | 1.7526 | 0.0000 | |
| SRP133303 | KPNA2 | 3838 | RNAseq | 2.0006 | 0.0000 | |
| SRP159526 | KPNA2 | 3838 | RNAseq | 1.6288 | 0.0000 | |
| SRP193095 | KPNA2 | 3838 | RNAseq | 1.1666 | 0.0000 | |
| SRP219564 | KPNA2 | 3838 | RNAseq | 1.3581 | 0.0099 | |
| TCGA | KPNA2 | 3838 | RNAseq | 0.5957 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by KPNA2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KPNA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KPNA2 | 3838 | 3 | 2 | 25 | |
| GSE20123 | KPNA2 | 3838 | 3 | 2 | 25 | |
| GSE43470 | KPNA2 | 3838 | 4 | 0 | 39 | |
| GSE46452 | KPNA2 | 3838 | 31 | 1 | 27 | |
| GSE47630 | KPNA2 | 3838 | 7 | 1 | 32 | |
| GSE54993 | KPNA2 | 3838 | 2 | 5 | 63 | |
| GSE54994 | KPNA2 | 3838 | 9 | 4 | 40 | |
| GSE60625 | KPNA2 | 3838 | 4 | 2 | 5 | |
| GSE74703 | KPNA2 | 3838 | 4 | 0 | 32 | |
| GSE74704 | KPNA2 | 3838 | 3 | 1 | 16 | |
| TCGA | KPNA2 | 3838 | 28 | 8 | 60 |
Total number of gains: 98; Total number of losses: 26; Total Number of normals: 364.
Somatic mutations of KPNA2:
Generating mutation plots.
Highly correlated genes for KPNA2:
Showing top 20/1740 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KPNA2 | KIF14 | 0.835277 | 10 | 0 | 10 |
| KPNA2 | NUF2 | 0.825889 | 6 | 0 | 6 |
| KPNA2 | MTFR2 | 0.824472 | 5 | 0 | 5 |
| KPNA2 | TOP2A | 0.81943 | 10 | 0 | 10 |
| KPNA2 | AURKA | 0.814837 | 10 | 0 | 10 |
| KPNA2 | NEK2 | 0.814163 | 10 | 0 | 10 |
| KPNA2 | XPOT | 0.813003 | 8 | 0 | 8 |
| KPNA2 | CCNA2 | 0.812263 | 10 | 0 | 10 |
| KPNA2 | CEP55 | 0.80654 | 10 | 0 | 10 |
| KPNA2 | BUB1B | 0.803748 | 9 | 0 | 8 |
| KPNA2 | KIF20A | 0.801775 | 10 | 0 | 10 |
| KPNA2 | ORC6 | 0.801224 | 9 | 0 | 9 |
| KPNA2 | RACGAP1 | 0.798718 | 10 | 0 | 9 |
| KPNA2 | TPX2 | 0.794368 | 10 | 0 | 10 |
| KPNA2 | TRIP13 | 0.793743 | 10 | 0 | 10 |
| KPNA2 | DTL | 0.79316 | 10 | 0 | 10 |
| KPNA2 | UHRF1 | 0.792254 | 6 | 0 | 6 |
| KPNA2 | CENPN | 0.79212 | 10 | 0 | 9 |
| KPNA2 | CDCA2 | 0.791007 | 6 | 0 | 6 |
| KPNA2 | CCNB2 | 0.790539 | 9 | 0 | 8 |
For details and further investigation, click here
