VAV1

 

Full name: vav guanine nucleotide exchange factor 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 7409 HGNC ID: HGNC:12657 Ensembl Gene: ENSG00000141968 OMIM ID: 164875
Drug and gene relationship at DGIdb

 

VAV1 involved pathways:

KEGG pathway Description View
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04510Focal adhesion
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton

 

Expression of VAV1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 VAV1 7409 206219_s_at 0.1612 0.7939
GSE20347 VAV1 7409 206219_s_at -0.0610 0.4765
GSE23400 VAV1 7409 206219_s_at -0.2094 0.0000
GSE26886 VAV1 7409 206219_s_at 0.1692 0.6215
GSE29001 VAV1 7409 206219_s_at 0.1188 0.6645
GSE38129 VAV1 7409 206219_s_at -0.0644 0.6681
GSE45670 VAV1 7409 206219_s_at -0.0399 0.8865
GSE53622 VAV1 7409 136452 0.1470 0.1717
GSE53624 VAV1 7409 136452 0.0223 0.8369
GSE63941 VAV1 7409 206219_s_at 1.5393 0.0631
GSE77861 VAV1 7409 206219_s_at -0.0292 0.8689
GSE97050 VAV1 7409 A_23_P38959 0.6959 0.1702
SRP007169 VAV1 7409 RNAseq 1.0425 0.2261
SRP064894 VAV1 7409 RNAseq 0.4242 0.1589
SRP133303 VAV1 7409 RNAseq 0.2326 0.3467
SRP159526 VAV1 7409 RNAseq -0.2160 0.7777
SRP193095 VAV1 7409 RNAseq 0.1699 0.4747
SRP219564 VAV1 7409 RNAseq 0.6174 0.1983
TCGA VAV1 7409 RNAseq 0.3279 0.1010

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by VAV1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of VAV1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 VAV1 7409 5 3 22
GSE20123 VAV1 7409 4 2 24
GSE43470 VAV1 7409 2 6 35
GSE46452 VAV1 7409 47 1 11
GSE47630 VAV1 7409 5 7 28
GSE54993 VAV1 7409 16 3 51
GSE54994 VAV1 7409 6 14 33
GSE60625 VAV1 7409 9 0 2
GSE74703 VAV1 7409 2 4 30
GSE74704 VAV1 7409 1 2 17
TCGA VAV1 7409 9 19 68

Total number of gains: 106; Total number of losses: 61; Total Number of normals: 321.  

 

Somatic mutations of VAV1:

 

Generating mutation plots.

 

Highly correlated genes for VAV1:

 

Showing top 20/240 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
VAV1AP1G20.689025303
VAV1MEI10.67613303
VAV1UBE2J20.672365303
VAV1SNX200.668066605
VAV1IKZF10.664907706
VAV1IFNAR20.664259404
VAV1NAGLU0.6599404
VAV1IRF80.659809909
VAV1SF3B10.656469303
VAV1C19orf380.654544303
VAV1SURF40.650455303
VAV1CR1L0.648905403
VAV1MDK0.648033303
VAV1CEACAM210.643066505
VAV1ACAP10.642695706
VAV1FGD30.642323504
VAV1BIN20.642195807
VAV1IL21R0.641719806
VAV1GMFG0.638825906
VAV1TMCO10.637115303

For details and further investigation, click here