| Full name: small ubiquitin like modifier 1 | Alias Symbol: PIC1|GMP1|SMT3C|SUMO-1|SMT3H3|OFC10 | ||
| Type: protein-coding gene | Cytoband: 2q33.1 | ||
| Entrez ID: 7341 | HGNC ID: HGNC:12502 | Ensembl Gene: ENSG00000116030 | OMIM ID: 601912 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SUMO1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SUMO1 | 7341 | 211069_s_at | 0.1228 | 0.8381 | |
| GSE20347 | SUMO1 | 7341 | 211069_s_at | 0.2895 | 0.0318 | |
| GSE23400 | SUMO1 | 7341 | 211069_s_at | 0.3229 | 0.0000 | |
| GSE26886 | SUMO1 | 7341 | 211069_s_at | 0.2814 | 0.1715 | |
| GSE29001 | SUMO1 | 7341 | 211069_s_at | 0.2462 | 0.1424 | |
| GSE38129 | SUMO1 | 7341 | 211069_s_at | 0.3946 | 0.0051 | |
| GSE45670 | SUMO1 | 7341 | 211069_s_at | 0.2668 | 0.0419 | |
| GSE53622 | SUMO1 | 7341 | 33727 | 0.4487 | 0.0000 | |
| GSE53624 | SUMO1 | 7341 | 33727 | 0.4016 | 0.0000 | |
| GSE63941 | SUMO1 | 7341 | 211069_s_at | -0.1964 | 0.4645 | |
| GSE77861 | SUMO1 | 7341 | 211069_s_at | 0.3191 | 0.0256 | |
| GSE97050 | SUMO1 | 7341 | A_24_P319354 | 0.2331 | 0.2560 | |
| SRP007169 | SUMO1 | 7341 | RNAseq | -0.2244 | 0.5446 | |
| SRP008496 | SUMO1 | 7341 | RNAseq | 0.0868 | 0.6929 | |
| SRP064894 | SUMO1 | 7341 | RNAseq | 0.1499 | 0.3806 | |
| SRP133303 | SUMO1 | 7341 | RNAseq | 0.3506 | 0.0088 | |
| SRP159526 | SUMO1 | 7341 | RNAseq | 0.2977 | 0.1241 | |
| SRP193095 | SUMO1 | 7341 | RNAseq | -0.1750 | 0.1864 | |
| SRP219564 | SUMO1 | 7341 | RNAseq | -0.1587 | 0.5461 | |
| TCGA | SUMO1 | 7341 | RNAseq | 0.1493 | 0.0024 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SUMO1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SUMO1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SUMO1 | 7341 | 7 | 4 | 19 | |
| GSE20123 | SUMO1 | 7341 | 7 | 4 | 19 | |
| GSE43470 | SUMO1 | 7341 | 1 | 3 | 39 | |
| GSE46452 | SUMO1 | 7341 | 1 | 4 | 54 | |
| GSE47630 | SUMO1 | 7341 | 4 | 5 | 31 | |
| GSE54993 | SUMO1 | 7341 | 0 | 3 | 67 | |
| GSE54994 | SUMO1 | 7341 | 10 | 8 | 35 | |
| GSE60625 | SUMO1 | 7341 | 0 | 3 | 8 | |
| GSE74703 | SUMO1 | 7341 | 1 | 2 | 33 | |
| GSE74704 | SUMO1 | 7341 | 3 | 2 | 15 | |
| TCGA | SUMO1 | 7341 | 21 | 11 | 64 |
Total number of gains: 55; Total number of losses: 49; Total Number of normals: 384.
Somatic mutations of SUMO1:
Generating mutation plots.
Highly correlated genes for SUMO1:
Showing top 20/185 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SUMO1 | KLRG2 | 0.68589 | 3 | 0 | 3 |
| SUMO1 | HSPE1 | 0.661774 | 10 | 0 | 9 |
| SUMO1 | SLC35G1 | 0.64656 | 4 | 0 | 3 |
| SUMO1 | SLFN5 | 0.642374 | 4 | 0 | 3 |
| SUMO1 | LSM8 | 0.639248 | 5 | 0 | 3 |
| SUMO1 | TANK | 0.636739 | 5 | 0 | 3 |
| SUMO1 | UGGT1 | 0.632484 | 5 | 0 | 3 |
| SUMO1 | RFC4 | 0.617061 | 9 | 0 | 7 |
| SUMO1 | RANBP2 | 0.615727 | 5 | 0 | 4 |
| SUMO1 | ECT2 | 0.614414 | 11 | 0 | 9 |
| SUMO1 | CDCA5 | 0.613995 | 5 | 0 | 4 |
| SUMO1 | DESI2 | 0.611508 | 8 | 0 | 7 |
| SUMO1 | CKS1B | 0.599364 | 8 | 0 | 7 |
| SUMO1 | PABPC1L | 0.599157 | 4 | 0 | 3 |
| SUMO1 | ZNF283 | 0.592102 | 4 | 0 | 3 |
| SUMO1 | CCDC138 | 0.591898 | 4 | 0 | 4 |
| SUMO1 | CBX3 | 0.59129 | 10 | 0 | 8 |
| SUMO1 | PCNA | 0.589655 | 8 | 0 | 7 |
| SUMO1 | TBCCD1 | 0.588448 | 9 | 0 | 8 |
| SUMO1 | CENPN | 0.587994 | 9 | 0 | 7 |
For details and further investigation, click here
