COL1A2

 

Full name: collagen type I alpha 2 chain Alias Symbol: 
Type: protein-coding gene Cytoband: 7q21.3
Entrez ID: 1278 HGNC ID: HGNC:2198 Ensembl Gene: ENSG00000164692 OMIM ID: 120160
Drug and gene relationship at DGIdb

 

COL1A2 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04611Platelet activation
hsa04933AGE-RAGE signaling pathway in diabetic complications

 

Expression of COL1A2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 COL1A2 1278 202403_s_at 1.0262 0.2913
GSE20347 COL1A2 1278 202403_s_at 2.3637 0.0001
GSE23400 COL1A2 1278 202403_s_at 1.7633 0.0000
GSE26886 COL1A2 1278 202403_s_at 3.1873 0.0000
GSE29001 COL1A2 1278 202404_s_at 2.4860 0.0000
GSE38129 COL1A2 1278 202404_s_at 3.1366 0.0000
GSE45670 COL1A2 1278 202404_s_at 1.3192 0.0808
GSE53622 COL1A2 1278 32856 1.1973 0.0000
GSE53624 COL1A2 1278 32856 0.8265 0.0000
GSE63941 COL1A2 1278 202403_s_at -9.1483 0.0000
GSE77861 COL1A2 1278 202403_s_at 2.6126 0.0106
GSE97050 COL1A2 1278 A_24_P277934 2.6688 0.0465
SRP007169 COL1A2 1278 RNAseq 6.9727 0.0000
SRP008496 COL1A2 1278 RNAseq 7.4538 0.0000
SRP064894 COL1A2 1278 RNAseq 2.8180 0.0000
SRP133303 COL1A2 1278 RNAseq 3.3723 0.0000
SRP159526 COL1A2 1278 RNAseq 1.5299 0.0012
SRP193095 COL1A2 1278 RNAseq 4.2897 0.0000
SRP219564 COL1A2 1278 RNAseq 2.4012 0.0056
TCGA COL1A2 1278 RNAseq 0.3283 0.0012

Upregulated datasets: 15; Downregulated datasets: 1.  

 

Survival by COL1A2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of COL1A2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 COL1A2 1278 13 0 17
GSE20123 COL1A2 1278 13 0 17
GSE43470 COL1A2 1278 7 3 33
GSE46452 COL1A2 1278 12 0 47
GSE47630 COL1A2 1278 8 2 30
GSE54993 COL1A2 1278 1 9 60
GSE54994 COL1A2 1278 16 2 35
GSE60625 COL1A2 1278 0 5 6
GSE74703 COL1A2 1278 6 2 28
GSE74704 COL1A2 1278 9 0 11
TCGA COL1A2 1278 56 4 36

Total number of gains: 141; Total number of losses: 27; Total Number of normals: 320.  

 

Somatic mutations of COL1A2:

 

Generating mutation plots.

 

Highly correlated genes for COL1A2:

 

Showing top 20/944 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
COL1A2COL3A10.92239813013
COL1A2COL6A30.90803613013
COL1A2COL1A10.89636612012
COL1A2COL5A20.88835813013
COL1A2SPARC0.88236613013
COL1A2VCAN0.87586813012
COL1A2POSTN0.87478613013
COL1A2CTSK0.85356612012
COL1A2FAP0.84091711011
COL1A2COL5A10.83884313013
COL1A2FN10.81851112012
COL1A2NID20.81029810010
COL1A2LUM0.8099413012
COL1A2THY10.8075413012
COL1A2CDH110.80597913012
COL1A2THBS20.80408113012
COL1A2SULF10.80386413013
COL1A2MMP20.79539813013
COL1A2OLFML2B0.79493212012
COL1A2CTHRC10.792321908

For details and further investigation, click here