| Full name: small G protein signaling modulator 3 | Alias Symbol: DJ1042K10.2|RUSC3|RabGAP-5|RABGAP5 | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 27352 | HGNC ID: HGNC:25228 | Ensembl Gene: ENSG00000100359 | OMIM ID: 610440 |
| Drug and gene relationship at DGIdb | |||
Expression of SGSM3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SGSM3 | 27352 | 214779_s_at | -0.2189 | 0.4167 | |
| GSE20347 | SGSM3 | 27352 | 214779_s_at | -0.4474 | 0.0000 | |
| GSE23400 | SGSM3 | 27352 | 203014_x_at | -0.2696 | 0.0000 | |
| GSE26886 | SGSM3 | 27352 | 203014_x_at | -0.2125 | 0.0977 | |
| GSE29001 | SGSM3 | 27352 | 203014_x_at | -0.3714 | 0.0272 | |
| GSE38129 | SGSM3 | 27352 | 214779_s_at | -0.3848 | 0.0000 | |
| GSE45670 | SGSM3 | 27352 | 214779_s_at | -0.1354 | 0.1498 | |
| GSE53622 | SGSM3 | 27352 | 7857 | -0.5524 | 0.0000 | |
| GSE53624 | SGSM3 | 27352 | 7857 | -0.5563 | 0.0000 | |
| GSE63941 | SGSM3 | 27352 | 214779_s_at | -0.3333 | 0.4538 | |
| GSE77861 | SGSM3 | 27352 | 203014_x_at | -0.0279 | 0.8959 | |
| GSE97050 | SGSM3 | 27352 | A_23_P166491 | 0.0901 | 0.8125 | |
| SRP007169 | SGSM3 | 27352 | RNAseq | -1.6686 | 0.0000 | |
| SRP008496 | SGSM3 | 27352 | RNAseq | -1.5874 | 0.0000 | |
| SRP064894 | SGSM3 | 27352 | RNAseq | -0.2093 | 0.3244 | |
| SRP133303 | SGSM3 | 27352 | RNAseq | -0.6461 | 0.0000 | |
| SRP159526 | SGSM3 | 27352 | RNAseq | -0.4052 | 0.0082 | |
| SRP193095 | SGSM3 | 27352 | RNAseq | -0.5655 | 0.0111 | |
| SRP219564 | SGSM3 | 27352 | RNAseq | -0.3707 | 0.1976 | |
| TCGA | SGSM3 | 27352 | RNAseq | -0.3588 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by SGSM3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SGSM3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SGSM3 | 27352 | 6 | 5 | 19 | |
| GSE20123 | SGSM3 | 27352 | 6 | 4 | 20 | |
| GSE43470 | SGSM3 | 27352 | 5 | 6 | 32 | |
| GSE46452 | SGSM3 | 27352 | 31 | 2 | 26 | |
| GSE47630 | SGSM3 | 27352 | 9 | 4 | 27 | |
| GSE54993 | SGSM3 | 27352 | 3 | 6 | 61 | |
| GSE54994 | SGSM3 | 27352 | 10 | 7 | 36 | |
| GSE60625 | SGSM3 | 27352 | 5 | 0 | 6 | |
| GSE74703 | SGSM3 | 27352 | 5 | 4 | 27 | |
| GSE74704 | SGSM3 | 27352 | 3 | 2 | 15 | |
| TCGA | SGSM3 | 27352 | 26 | 16 | 54 |
Total number of gains: 109; Total number of losses: 56; Total Number of normals: 323.
Somatic mutations of SGSM3:
Generating mutation plots.
Highly correlated genes for SGSM3:
Showing top 20/570 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SGSM3 | RECQL5 | 0.686057 | 9 | 0 | 9 |
| SGSM3 | TMEM222 | 0.669838 | 6 | 0 | 6 |
| SGSM3 | CITED4 | 0.658701 | 4 | 0 | 4 |
| SGSM3 | RHOF | 0.655877 | 3 | 0 | 3 |
| SGSM3 | DYRK1B | 0.655487 | 4 | 0 | 3 |
| SGSM3 | PAQR8 | 0.654465 | 4 | 0 | 4 |
| SGSM3 | VSIG2 | 0.654155 | 4 | 0 | 4 |
| SGSM3 | AP1B1 | 0.649295 | 10 | 0 | 10 |
| SGSM3 | TMEM219 | 0.645037 | 4 | 0 | 3 |
| SGSM3 | MPST | 0.637416 | 9 | 0 | 7 |
| SGSM3 | GRK6 | 0.635157 | 3 | 0 | 3 |
| SGSM3 | ST6GALNAC1 | 0.627779 | 4 | 0 | 4 |
| SGSM3 | PHC1 | 0.626601 | 5 | 0 | 5 |
| SGSM3 | DENND2D | 0.625304 | 8 | 0 | 7 |
| SGSM3 | SLC37A1 | 0.622633 | 8 | 0 | 6 |
| SGSM3 | B3GALT4 | 0.622274 | 7 | 0 | 7 |
| SGSM3 | SLC35C1 | 0.620816 | 10 | 0 | 9 |
| SGSM3 | CLPP | 0.620056 | 3 | 0 | 3 |
| SGSM3 | LLGL2 | 0.618794 | 10 | 0 | 8 |
| SGSM3 | C2CD2L | 0.616463 | 7 | 0 | 6 |
For details and further investigation, click here
