| Full name: caseinolytic mitochondrial matrix peptidase proteolytic subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 8192 | HGNC ID: HGNC:2084 | Ensembl Gene: ENSG00000125656 | OMIM ID: 601119 |
| Drug and gene relationship at DGIdb | |||
Expression of CLPP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLPP | 8192 | 202799_at | 0.1109 | 0.7415 | |
| GSE20347 | CLPP | 8192 | 202799_at | -0.1750 | 0.2242 | |
| GSE23400 | CLPP | 8192 | 202799_at | -0.2355 | 0.0000 | |
| GSE26886 | CLPP | 8192 | 202799_at | 0.3702 | 0.0507 | |
| GSE29001 | CLPP | 8192 | 202799_at | -0.3746 | 0.3372 | |
| GSE38129 | CLPP | 8192 | 202799_at | -0.0173 | 0.8994 | |
| GSE45670 | CLPP | 8192 | 202799_at | -0.0538 | 0.7242 | |
| GSE53622 | CLPP | 8192 | 103881 | -0.0790 | 0.1460 | |
| GSE53624 | CLPP | 8192 | 103881 | -0.2548 | 0.0000 | |
| GSE63941 | CLPP | 8192 | 202799_at | 0.3578 | 0.2405 | |
| GSE77861 | CLPP | 8192 | 202799_at | 0.0442 | 0.8015 | |
| GSE97050 | CLPP | 8192 | A_23_P4754 | 0.0108 | 0.9666 | |
| SRP007169 | CLPP | 8192 | RNAseq | -1.0300 | 0.0017 | |
| SRP008496 | CLPP | 8192 | RNAseq | -0.8176 | 0.0000 | |
| SRP064894 | CLPP | 8192 | RNAseq | 0.3347 | 0.2901 | |
| SRP133303 | CLPP | 8192 | RNAseq | -0.1090 | 0.4564 | |
| SRP159526 | CLPP | 8192 | RNAseq | -0.2533 | 0.0841 | |
| SRP193095 | CLPP | 8192 | RNAseq | -0.2386 | 0.0162 | |
| SRP219564 | CLPP | 8192 | RNAseq | -0.2843 | 0.3304 | |
| TCGA | CLPP | 8192 | RNAseq | 0.0324 | 0.5677 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CLPP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLPP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLPP | 8192 | 5 | 3 | 22 | |
| GSE20123 | CLPP | 8192 | 4 | 2 | 24 | |
| GSE43470 | CLPP | 8192 | 2 | 6 | 35 | |
| GSE46452 | CLPP | 8192 | 47 | 1 | 11 | |
| GSE47630 | CLPP | 8192 | 5 | 7 | 28 | |
| GSE54993 | CLPP | 8192 | 16 | 3 | 51 | |
| GSE54994 | CLPP | 8192 | 6 | 16 | 31 | |
| GSE60625 | CLPP | 8192 | 9 | 0 | 2 | |
| GSE74703 | CLPP | 8192 | 2 | 4 | 30 | |
| GSE74704 | CLPP | 8192 | 1 | 2 | 17 | |
| TCGA | CLPP | 8192 | 9 | 19 | 68 |
Total number of gains: 106; Total number of losses: 63; Total Number of normals: 319.
Somatic mutations of CLPP:
Generating mutation plots.
Highly correlated genes for CLPP:
Showing top 20/358 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLPP | PTOV1 | 0.766761 | 3 | 0 | 3 |
| CLPP | UFSP2 | 0.736832 | 3 | 0 | 3 |
| CLPP | MRPL38 | 0.715845 | 4 | 0 | 4 |
| CLPP | SCAF1 | 0.715459 | 3 | 0 | 3 |
| CLPP | NOC2L | 0.710631 | 4 | 0 | 3 |
| CLPP | ERCC2 | 0.691438 | 3 | 0 | 3 |
| CLPP | C2orf49 | 0.68992 | 3 | 0 | 3 |
| CLPP | OS9 | 0.68666 | 4 | 0 | 4 |
| CLPP | GTPBP10 | 0.678264 | 3 | 0 | 3 |
| CLPP | UBE2L3 | 0.673402 | 5 | 0 | 5 |
| CLPP | HDDC2 | 0.672735 | 3 | 0 | 3 |
| CLPP | CCL22 | 0.671187 | 3 | 0 | 3 |
| CLPP | TEAD2 | 0.666355 | 3 | 0 | 3 |
| CLPP | KRAS | 0.666035 | 3 | 0 | 3 |
| CLPP | MLLT1 | 0.663364 | 4 | 0 | 3 |
| CLPP | PNKP | 0.663024 | 5 | 0 | 4 |
| CLPP | IRF2BP1 | 0.662508 | 4 | 0 | 3 |
| CLPP | CATSPER1 | 0.662109 | 3 | 0 | 3 |
| CLPP | NIPSNAP1 | 0.660309 | 4 | 0 | 3 |
| CLPP | SLC45A3 | 0.65929 | 3 | 0 | 3 |
For details and further investigation, click here
