| Full name: sphingomyelin phosphodiesterase 2 | Alias Symbol: nSMase|ISC1 | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 6610 | HGNC ID: HGNC:11121 | Ensembl Gene: ENSG00000135587 | OMIM ID: 603498 |
| Drug and gene relationship at DGIdb | |||
SMPD2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04071 | Sphingolipid signaling pathway |
Expression of SMPD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMPD2 | 6610 | 205622_at | -0.6167 | 0.1500 | |
| GSE20347 | SMPD2 | 6610 | 205622_at | -1.0583 | 0.0000 | |
| GSE23400 | SMPD2 | 6610 | 205622_at | -0.6758 | 0.0000 | |
| GSE26886 | SMPD2 | 6610 | 205622_at | -0.9801 | 0.0000 | |
| GSE29001 | SMPD2 | 6610 | 205622_at | -1.0750 | 0.0000 | |
| GSE38129 | SMPD2 | 6610 | 205622_at | -0.6911 | 0.0001 | |
| GSE45670 | SMPD2 | 6610 | 205622_at | -0.4112 | 0.0095 | |
| GSE53622 | SMPD2 | 6610 | 23783 | -0.8638 | 0.0000 | |
| GSE53624 | SMPD2 | 6610 | 23783 | -1.1629 | 0.0000 | |
| GSE63941 | SMPD2 | 6610 | 205622_at | 0.0825 | 0.7518 | |
| GSE77861 | SMPD2 | 6610 | 205622_at | -0.7390 | 0.0186 | |
| GSE97050 | SMPD2 | 6610 | A_23_P82162 | 0.0506 | 0.8906 | |
| SRP007169 | SMPD2 | 6610 | RNAseq | -2.9530 | 0.0000 | |
| SRP008496 | SMPD2 | 6610 | RNAseq | -2.3786 | 0.0000 | |
| SRP064894 | SMPD2 | 6610 | RNAseq | -1.2474 | 0.0000 | |
| SRP133303 | SMPD2 | 6610 | RNAseq | -1.1504 | 0.0000 | |
| SRP159526 | SMPD2 | 6610 | RNAseq | -0.7340 | 0.0952 | |
| SRP193095 | SMPD2 | 6610 | RNAseq | -1.2150 | 0.0000 | |
| SRP219564 | SMPD2 | 6610 | RNAseq | -1.1250 | 0.0344 | |
| TCGA | SMPD2 | 6610 | RNAseq | -0.1469 | 0.0991 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by SMPD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMPD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMPD2 | 6610 | 3 | 3 | 24 | |
| GSE20123 | SMPD2 | 6610 | 3 | 2 | 25 | |
| GSE43470 | SMPD2 | 6610 | 3 | 1 | 39 | |
| GSE46452 | SMPD2 | 6610 | 2 | 11 | 46 | |
| GSE47630 | SMPD2 | 6610 | 9 | 4 | 27 | |
| GSE54993 | SMPD2 | 6610 | 3 | 2 | 65 | |
| GSE54994 | SMPD2 | 6610 | 8 | 8 | 37 | |
| GSE60625 | SMPD2 | 6610 | 0 | 2 | 9 | |
| GSE74703 | SMPD2 | 6610 | 2 | 1 | 33 | |
| GSE74704 | SMPD2 | 6610 | 1 | 0 | 19 | |
| TCGA | SMPD2 | 6610 | 6 | 24 | 66 |
Total number of gains: 40; Total number of losses: 58; Total Number of normals: 390.
Somatic mutations of SMPD2:
Generating mutation plots.
Highly correlated genes for SMPD2:
Showing top 20/1634 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMPD2 | SFTA2 | 0.803838 | 4 | 0 | 4 |
| SMPD2 | SLC16A6 | 0.799225 | 11 | 0 | 11 |
| SMPD2 | GDPD3 | 0.789215 | 10 | 0 | 10 |
| SMPD2 | GYS2 | 0.784533 | 10 | 0 | 10 |
| SMPD2 | TECR | 0.779211 | 10 | 0 | 10 |
| SMPD2 | TOM1 | 0.778083 | 11 | 0 | 10 |
| SMPD2 | NAGK | 0.777387 | 11 | 0 | 11 |
| SMPD2 | SCNN1B | 0.775656 | 10 | 0 | 10 |
| SMPD2 | RAB25 | 0.773622 | 11 | 0 | 11 |
| SMPD2 | SMAGP | 0.772871 | 10 | 0 | 10 |
| SMPD2 | GMDS | 0.772105 | 10 | 0 | 10 |
| SMPD2 | ENDOU | 0.770627 | 11 | 0 | 11 |
| SMPD2 | PADI1 | 0.770542 | 8 | 0 | 8 |
| SMPD2 | BLNK | 0.768713 | 11 | 0 | 11 |
| SMPD2 | UPK1A | 0.767238 | 10 | 0 | 10 |
| SMPD2 | EHD3 | 0.766351 | 11 | 0 | 11 |
| SMPD2 | MFSD5 | 0.764127 | 11 | 0 | 11 |
| SMPD2 | SLURP1 | 0.764022 | 10 | 0 | 10 |
| SMPD2 | SNORA68 | 0.763277 | 4 | 0 | 4 |
| SMPD2 | ACPP | 0.762235 | 10 | 0 | 10 |
For details and further investigation, click here
