BIRC5

 

Full name: baculoviral IAP repeat containing 5 Alias Symbol: EPR-1|survivin
Type: protein-coding gene Cytoband: 17q25.3
Entrez ID: 332 HGNC ID: HGNC:593 Ensembl Gene: ENSG00000089685 OMIM ID: 603352
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

BIRC5 involved pathways:

KEGG pathway Description View
hsa04210Apoptosis
hsa04390Hippo signaling pathway
hsa05161Hepatitis B
hsa05200Pathways in cancer
hsa05210Colorectal cancer

 

Expression of BIRC5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BIRC5 332 202095_s_at 1.5531 0.0559
GSE20347 BIRC5 332 202095_s_at 1.5560 0.0000
GSE23400 BIRC5 332 210334_x_at 0.2732 0.0000
GSE26886 BIRC5 332 202095_s_at 0.4475 0.2511
GSE29001 BIRC5 332 202094_at 1.3201 0.0002
GSE38129 BIRC5 332 202095_s_at 2.1752 0.0000
GSE45670 BIRC5 332 202095_s_at 1.3595 0.0000
GSE53622 BIRC5 332 86290 1.7267 0.0000
GSE53624 BIRC5 332 86290 2.1063 0.0000
GSE63941 BIRC5 332 202095_s_at 3.0389 0.0002
GSE77861 BIRC5 332 202095_s_at 0.7458 0.0083
GSE97050 BIRC5 332 A_23_P118815 1.7501 0.1189
SRP007169 BIRC5 332 RNAseq 2.1477 0.0000
SRP008496 BIRC5 332 RNAseq 1.5014 0.0000
SRP064894 BIRC5 332 RNAseq 2.0536 0.0000
SRP133303 BIRC5 332 RNAseq 2.0453 0.0000
SRP159526 BIRC5 332 RNAseq 1.9404 0.0000
SRP193095 BIRC5 332 RNAseq 1.2682 0.0000
SRP219564 BIRC5 332 RNAseq 1.6539 0.0281
TCGA BIRC5 332 RNAseq 1.5040 0.0000

Upregulated datasets: 15; Downregulated datasets: 0.  

 

Survival by BIRC5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BIRC5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BIRC5 332 5 4 21
GSE20123 BIRC5 332 5 4 21
GSE43470 BIRC5 332 3 4 36
GSE46452 BIRC5 332 33 0 26
GSE47630 BIRC5 332 8 1 31
GSE54993 BIRC5 332 2 5 63
GSE54994 BIRC5 332 10 4 39
GSE60625 BIRC5 332 6 0 5
GSE74703 BIRC5 332 3 2 31
GSE74704 BIRC5 332 4 3 13
TCGA BIRC5 332 31 8 57

Total number of gains: 110; Total number of losses: 35; Total Number of normals: 343.  

 

Somatic mutations of BIRC5:

 

Generating mutation plots.

 

Highly correlated genes for BIRC5:

 

Showing top 20/2086 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BIRC5TPX20.85608312012
BIRC5BUB10.84428410010
BIRC5UHRF10.842648808
BIRC5AURKB0.84251912012
BIRC5TOP2A0.84097612012
BIRC5UBE2C0.83927712012
BIRC5ESCO20.835212707
BIRC5CDCA20.827863606
BIRC5BUB1B0.823168908
BIRC5MELK0.82274612012
BIRC5NCAPH0.822571909
BIRC5DKC10.821495303
BIRC5FANCD20.817207606
BIRC5CKS1B0.81618911011
BIRC5CDC450.81452512012
BIRC5SPAG50.81448612012
BIRC5CEP550.81310613012
BIRC5KIF20A0.81224712012
BIRC5CDCA30.80973912012
BIRC5PRC10.8094812012

For details and further investigation, click here