| Full name: sirtuin 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 51548 | HGNC ID: HGNC:14934 | Ensembl Gene: | OMIM ID: 606211 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SIRT6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIRT6 | 51548 | 233179_x_at | 0.0643 | 0.7751 | |
| GSE20347 | SIRT6 | 51548 | 219613_s_at | -0.0354 | 0.7114 | |
| GSE23400 | SIRT6 | 51548 | 219613_s_at | -0.1313 | 0.0020 | |
| GSE26886 | SIRT6 | 51548 | 233179_x_at | 0.4764 | 0.0002 | |
| GSE29001 | SIRT6 | 51548 | 219613_s_at | -0.2981 | 0.0244 | |
| GSE38129 | SIRT6 | 51548 | 219613_s_at | 0.0447 | 0.5483 | |
| GSE45670 | SIRT6 | 51548 | 233179_x_at | 0.1045 | 0.1207 | |
| GSE53622 | SIRT6 | 51548 | 9634 | 0.4151 | 0.0000 | |
| GSE53624 | SIRT6 | 51548 | 9634 | 0.6499 | 0.0000 | |
| GSE63941 | SIRT6 | 51548 | 233179_x_at | 0.4557 | 0.0085 | |
| GSE77861 | SIRT6 | 51548 | 219613_s_at | -0.0674 | 0.5635 | |
| GSE97050 | SIRT6 | 51548 | A_23_P208847 | 0.3475 | 0.1852 | |
| SRP007169 | SIRT6 | 51548 | RNAseq | 0.2221 | 0.5826 | |
| SRP008496 | SIRT6 | 51548 | RNAseq | 0.3287 | 0.2078 | |
| SRP064894 | SIRT6 | 51548 | RNAseq | 0.9582 | 0.0007 | |
| SRP133303 | SIRT6 | 51548 | RNAseq | 0.2104 | 0.2700 | |
| SRP159526 | SIRT6 | 51548 | RNAseq | 0.3830 | 0.0517 | |
| SRP193095 | SIRT6 | 51548 | RNAseq | 0.1273 | 0.3408 | |
| SRP219564 | SIRT6 | 51548 | RNAseq | 0.2913 | 0.2643 | |
| TCGA | SIRT6 | 51548 | RNAseq | 0.2036 | 0.0020 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIRT6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIRT6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIRT6 | 51548 | 5 | 3 | 22 | |
| GSE20123 | SIRT6 | 51548 | 4 | 2 | 24 | |
| GSE43470 | SIRT6 | 51548 | 1 | 8 | 34 | |
| GSE46452 | SIRT6 | 51548 | 47 | 1 | 11 | |
| GSE47630 | SIRT6 | 51548 | 5 | 7 | 28 | |
| GSE54993 | SIRT6 | 51548 | 16 | 3 | 51 | |
| GSE54994 | SIRT6 | 51548 | 6 | 16 | 31 | |
| GSE60625 | SIRT6 | 51548 | 9 | 0 | 2 | |
| GSE74703 | SIRT6 | 51548 | 1 | 5 | 30 | |
| GSE74704 | SIRT6 | 51548 | 1 | 2 | 17 | |
| TCGA | SIRT6 | 51548 | 11 | 18 | 67 |
Total number of gains: 106; Total number of losses: 65; Total Number of normals: 317.
Somatic mutations of SIRT6:
Generating mutation plots.
Highly correlated genes for SIRT6:
Showing top 20/418 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIRT6 | NPBWR1 | 0.764467 | 3 | 0 | 3 |
| SIRT6 | PSTPIP1 | 0.719507 | 3 | 0 | 3 |
| SIRT6 | FAM181A | 0.708894 | 3 | 0 | 3 |
| SIRT6 | CCNJL | 0.705283 | 4 | 0 | 4 |
| SIRT6 | CHD5 | 0.695239 | 3 | 0 | 3 |
| SIRT6 | CFC1 | 0.693948 | 3 | 0 | 3 |
| SIRT6 | SLC22A13 | 0.690897 | 4 | 0 | 4 |
| SIRT6 | CALCA | 0.690194 | 4 | 0 | 4 |
| SIRT6 | MEGF11 | 0.690121 | 3 | 0 | 3 |
| SIRT6 | CELF4 | 0.685979 | 4 | 0 | 4 |
| SIRT6 | CAPN13 | 0.677729 | 3 | 0 | 3 |
| SIRT6 | CDHR2 | 0.670295 | 3 | 0 | 3 |
| SIRT6 | RANBP3 | 0.666414 | 4 | 0 | 3 |
| SIRT6 | PTGDR2 | 0.665846 | 3 | 0 | 3 |
| SIRT6 | EXTL1 | 0.663734 | 4 | 0 | 4 |
| SIRT6 | TAOK2 | 0.661828 | 4 | 0 | 4 |
| SIRT6 | ZAN | 0.659486 | 3 | 0 | 3 |
| SIRT6 | ADAMTS2 | 0.655615 | 5 | 0 | 3 |
| SIRT6 | FAM178B | 0.655573 | 3 | 0 | 3 |
| SIRT6 | SLC4A1 | 0.655223 | 4 | 0 | 3 |
For details and further investigation, click here
