SLC18B1

 

Full name: solute carrier family 18 member B1 Alias Symbol: dJ55C23.6
Type: protein-coding gene Cytoband: 6q23.2
Entrez ID: 116843 HGNC ID: HGNC:21573 Ensembl Gene: ENSG00000146409 OMIM ID: 613361
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SLC18B1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SLC18B1 116843 226301_at -0.1698 0.7370
GSE26886 SLC18B1 116843 226301_at -1.4239 0.0000
GSE45670 SLC18B1 116843 226301_at -0.3671 0.1170
GSE53622 SLC18B1 116843 64438 -0.5607 0.0000
GSE53624 SLC18B1 116843 33178 -0.6730 0.0000
GSE63941 SLC18B1 116843 226301_at -0.4756 0.6484
GSE77861 SLC18B1 116843 226301_at -1.4490 0.0042
SRP007169 SLC18B1 116843 RNAseq -0.2783 0.5428
SRP064894 SLC18B1 116843 RNAseq -0.3458 0.0845
SRP133303 SLC18B1 116843 RNAseq -0.8829 0.0007
SRP159526 SLC18B1 116843 RNAseq -0.6584 0.0269
SRP193095 SLC18B1 116843 RNAseq -0.6946 0.0001
SRP219564 SLC18B1 116843 RNAseq -0.6264 0.0689

Upregulated datasets: 0; Downregulated datasets: 2.  


 

Survival by SLC18B1 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  


Copy number change of SLC18B1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SLC18B1 116843 3 4 23
GSE20123 SLC18B1 116843 3 3 24
GSE43470 SLC18B1 116843 5 0 38
GSE46452 SLC18B1 116843 2 11 46
GSE47630 SLC18B1 116843 9 4 27
GSE54993 SLC18B1 116843 3 2 65
GSE54994 SLC18B1 116843 9 7 37
GSE60625 SLC18B1 116843 0 1 10
GSE74703 SLC18B1 116843 4 0 32
GSE74704 SLC18B1 116843 1 1 18
TCGA SLC18B1 116843 11 18 67

Total number of gains: 50; Total number of losses: 51; Total Number of normals: 387.  


 

Somatic mutations of SLC18B1:

 

Generating mutation plots.

 

Highly correlated genes for SLC18B1:

 

Showing top 20/594 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SLC18B1EPB41L4A0.717393303
SLC18B1ACVR1B0.692223303
SLC18B1ACAD80.691889403
SLC18B1DEPTOR0.689481303
SLC18B1FCGBP0.681686303
SLC18B1TESK20.678495404
SLC18B1USP460.677706504
SLC18B1PRR15L0.674164404
SLC18B1MTFR1L0.672446303
SLC18B1STT3B0.671429404
SLC18B1ACOX30.670637606
SLC18B1RIPK40.667666303
SLC18B1ZNF6260.667208303
SLC18B1RNF320.666037303
SLC18B1NT5C20.655849606
SLC18B1LMBRD10.65423505
SLC18B1MBNL30.653898604
SLC18B1TMEM590.653814505
SLC18B1SESN10.650928404
SLC18B1SCP20.646547605

For details and further investigation, click here