ADIPOQ

 

Full name: adiponectin, C1Q and collagen domain containing Alias Symbol: ACRP30|AdipoQ|apM1|GBP28|adiponectin
Type: protein-coding gene Cytoband: 3q27.3
Entrez ID: 9370 HGNC ID: HGNC:13633 Ensembl Gene: ENSG00000181092 OMIM ID: 605441
Drug and gene relationship at DGIdb

 

ADIPOQ involved pathways:

KEGG pathway Description View
hsa03320PPAR signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa04932Non-alcoholic fatty liver disease (NAFLD)

 

Expression of ADIPOQ:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADIPOQ 9370 207175_at -0.2345 0.4370
GSE20347 ADIPOQ 9370 207175_at 0.0463 0.5371
GSE23400 ADIPOQ 9370 207175_at -0.2148 0.0001
GSE26886 ADIPOQ 9370 207175_at -0.0218 0.8139
GSE29001 ADIPOQ 9370 207175_at -0.0896 0.6571
GSE38129 ADIPOQ 9370 207175_at -0.8710 0.0338
GSE45670 ADIPOQ 9370 207175_at -0.3238 0.0001
GSE53622 ADIPOQ 9370 63213 -0.3144 0.0978
GSE53624 ADIPOQ 9370 63213 -0.2116 0.2274
GSE63941 ADIPOQ 9370 207175_at 0.0490 0.7349
GSE77861 ADIPOQ 9370 207175_at 0.0507 0.6120
SRP133303 ADIPOQ 9370 RNAseq -0.1799 0.4449
TCGA ADIPOQ 9370 RNAseq -4.9592 0.0016

Upregulated datasets: 0; Downregulated datasets: 1.  


 

Survival by ADIPOQ expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of ADIPOQ:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADIPOQ 9370 24 0 6
GSE20123 ADIPOQ 9370 24 0 6
GSE43470 ADIPOQ 9370 23 1 19
GSE46452 ADIPOQ 9370 19 1 39
GSE47630 ADIPOQ 9370 27 2 11
GSE54993 ADIPOQ 9370 1 19 50
GSE54994 ADIPOQ 9370 40 0 13
GSE60625 ADIPOQ 9370 0 6 5
GSE74703 ADIPOQ 9370 20 1 15
GSE74704 ADIPOQ 9370 16 0 4
TCGA ADIPOQ 9370 77 0 19

Total number of gains: 271; Total number of losses: 30; Total Number of normals: 187.  


 

Somatic mutations of ADIPOQ:

 

Generating mutation plots.

 

Highly correlated genes for ADIPOQ:

 

Showing top 20/84 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADIPOQALAS20.744448303
ADIPOQSLC22A20.722316303
ADIPOQNIPSNAP3B0.688712303
ADIPOQLRRC20.656193505
ADIPOQGPR1820.651778303
ADIPOQMAPK40.647221303
ADIPOQCNTN20.642599303
ADIPOQHGD0.639487303
ADIPOQTNR0.631672403
ADIPOQTSPO20.62676303
ADIPOQTBX50.624114303
ADIPOQCNPY10.618791303
ADIPOQCCIN0.612965403
ADIPOQNPY5R0.610425503
ADIPOQSCGB2A20.61018303
ADIPOQHCG90.60895504
ADIPOQSIRPB10.606878403
ADIPOQGRM10.606427303
ADIPOQTIMP40.605069503
ADIPOQNPY1R0.60257403

For details and further investigation, click here