SLC22A4

 

Full name: solute carrier family 22 member 4 Alias Symbol: OCTN1|MGC34546
Type: protein-coding gene Cytoband: 5q31.1
Entrez ID: 6583 HGNC ID: HGNC:10968 Ensembl Gene: ENSG00000197208 OMIM ID: 604190
Drug and gene relationship at DGIdb

 

SLC22A4 involved pathways:

KEGG pathway Description View
hsa05231Choline metabolism in cancer

 

Expression of SLC22A4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SLC22A4 6583 205896_at 0.9607 0.1410
GSE20347 SLC22A4 6583 205896_at 0.3996 0.0037
GSE23400 SLC22A4 6583 205896_at 0.0889 0.0125
GSE26886 SLC22A4 6583 205896_at 1.3932 0.0001
GSE29001 SLC22A4 6583 205896_at 0.5160 0.0486
GSE38129 SLC22A4 6583 205896_at 0.3059 0.0624
GSE45670 SLC22A4 6583 205896_at 0.4511 0.2907
GSE53622 SLC22A4 6583 45171 0.9139 0.0000
GSE53624 SLC22A4 6583 45171 1.3748 0.0000
GSE63941 SLC22A4 6583 205896_at -2.6421 0.0048
GSE77861 SLC22A4 6583 205896_at 0.1165 0.2561
GSE97050 SLC22A4 6583 A_23_P156180 0.1527 0.4901
SRP007169 SLC22A4 6583 RNAseq 2.5522 0.0285
SRP064894 SLC22A4 6583 RNAseq 0.8831 0.0035
SRP133303 SLC22A4 6583 RNAseq 0.7047 0.0225
SRP159526 SLC22A4 6583 RNAseq 1.0027 0.0823
SRP193095 SLC22A4 6583 RNAseq 0.8016 0.0001
SRP219564 SLC22A4 6583 RNAseq 1.3835 0.0267
TCGA SLC22A4 6583 RNAseq 0.6721 0.0018

Upregulated datasets: 4; Downregulated datasets: 1.  

 

Survival by SLC22A4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SLC22A4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SLC22A4 6583 1 11 18
GSE20123 SLC22A4 6583 2 11 17
GSE43470 SLC22A4 6583 2 9 32
GSE46452 SLC22A4 6583 0 27 32
GSE47630 SLC22A4 6583 0 21 19
GSE54993 SLC22A4 6583 9 1 60
GSE54994 SLC22A4 6583 2 14 37
GSE60625 SLC22A4 6583 0 0 11
GSE74703 SLC22A4 6583 2 6 28
GSE74704 SLC22A4 6583 1 5 14
TCGA SLC22A4 6583 3 39 54

Total number of gains: 22; Total number of losses: 144; Total Number of normals: 322.  

 

Somatic mutations of SLC22A4:

 

Generating mutation plots.

 

Highly correlated genes for SLC22A4:

 

Showing top 20/640 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SLC22A4OGDHL0.707207303
SLC22A4CERCAM0.692157303
SLC22A4CHSY30.678368707
SLC22A4ARSI0.676608404
SLC22A4PPP1R180.657869605
SLC22A4CTHRC10.656142606
SLC22A4GPX80.650599707
SLC22A4APCDD1L0.649504505
SLC22A4COL13A10.648567605
SLC22A4MSRB10.648102403
SLC22A4SLC25A320.645787707
SLC22A4SLC39A140.642815807
SLC22A4LOX0.641716706
SLC22A4MMD0.64000610010
SLC22A4GLIS30.63955505
SLC22A4KTN10.631589605
SLC22A4LHFPL20.6275951209
SLC22A4DACT10.6272871009
SLC22A4SPRED10.626585604
SLC22A4RTTN0.626271403

For details and further investigation, click here