Full name: aryl hydrocarbon receptor	Alias Symbol: bHLHe76
Type: protein-coding gene	Cytoband: 7p21.1
Entrez ID: 196	HGNC ID: HGNC:348	Ensembl Gene: ENSG00000106546	OMIM ID: 600253
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 6/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

---

 

Expression of AHR:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	AHR	196	202820_at	0.7115	0.3698	Show
GSE20347	AHR	196	202820_at	0.9708	0.0002	Show
GSE23400	AHR	196	202820_at	0.7975	0.0000	Show
GSE26886	AHR	196	202820_at	2.7718	0.0000	Show
GSE29001	AHR	196	202820_at	1.3532	0.0001	Show
GSE38129	AHR	196	202820_at	0.9273	0.0000	Show
GSE45670	AHR	196	202820_at	0.3758	0.2752	Show
GSE53622	AHR	196	48664	0.9350	0.0000	Show
GSE53624	AHR	196	8167	0.7042	0.0000	Show
GSE63941	AHR	196	202820_at	-0.7064	0.3238	Show
GSE77861	AHR	196	202820_at	1.4696	0.0080	Show
GSE97050	AHR	196	A_33_P3316800	1.1132	0.1142	Show
SRP007169	AHR	196	RNAseq	1.0187	0.0227	Show
SRP008496	AHR	196	RNAseq	1.7830	0.0000	Show
SRP064894	AHR	196	RNAseq	0.6878	0.0126	Show
SRP133303	AHR	196	RNAseq	0.7130	0.0001	Show
SRP159526	AHR	196	RNAseq	0.8669	0.1319	Show
SRP193095	AHR	196	RNAseq	0.9951	0.0000	Show
SRP219564	AHR	196	RNAseq	0.7213	0.0747	Show
TCGA	AHR	196	RNAseq	0.1700	0.0171	Show

Upregulated datasets: 5; Downregulated datasets: 0.  Download Data

---

 

Survival by AHR expression:

 

---

Copy number change of AHR:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	AHR	196	15	2	13	Show
GSE20123	AHR	196	15	2	13	Show
GSE43470	AHR	196	5	0	38	Show
GSE46452	AHR	196	11	1	47	Show
GSE47630	AHR	196	9	1	30	Show
GSE54993	AHR	196	0	6	64	Show
GSE54994	AHR	196	21	1	31	Show
GSE60625	AHR	196	0	0	11	Show
GSE74703	AHR	196	5	0	31	Show
GSE74704	AHR	196	9	2	9	Show
TCGA	AHR	196	56	5	35	Show

Total number of gains: 146; Total number of losses: 20; Total Number of normals: 322.  Download Data

---

 

Somatic mutations of AHR:

 

---

 

Highly correlated genes for AHR:

 

Showing top 20/1222 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
AHR	LRRC8C	0.783291	3	0	3
AHR	AFAP1L2	0.76628	3	0	3
AHR	TGFBI	0.762504	11	0	11
AHR	ZNF417	0.760233	3	0	3
AHR	XPR1	0.74859	7	0	6
AHR	HAS3	0.747046	4	0	3
AHR	COL5A2	0.742619	11	0	11
AHR	DDX60L	0.740024	3	0	3
AHR	CYP26B1	0.739822	3	0	3
AHR	WDR54	0.738166	7	0	7
AHR	MGAT5	0.734203	3	0	3
AHR	IKBIP	0.732881	7	0	7
AHR	CD276	0.730226	4	0	4
AHR	SLC38A6	0.72922	8	0	8
AHR	ZNF469	0.724044	6	0	6
AHR	FAM89A	0.721968	3	0	3
AHR	PHRF1	0.720475	3	0	3
AHR	SLC39A14	0.720041	11	0	11
AHR	PRSS23	0.719127	11	0	11
AHR	FMNL2	0.717746	7	0	6

For details and further investigation, click here