MCM8

 

Full name: minichromosome maintenance 8 homologous recombination repair factor Alias Symbol: MGC4816|MGC12866|MGC119522|MGC119523|dJ967N21.5|REC
Type: protein-coding gene Cytoband: 20p12.3
Entrez ID: 84515 HGNC ID: HGNC:16147 Ensembl Gene: ENSG00000125885 OMIM ID: 608187
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of MCM8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MCM8 84515 224320_s_at 1.1294 0.0280
GSE26886 MCM8 84515 224320_s_at 1.0735 0.0005
GSE45670 MCM8 84515 224320_s_at 1.4111 0.0000
GSE53622 MCM8 84515 149422 1.0731 0.0000
GSE53624 MCM8 84515 149422 1.1908 0.0000
GSE63941 MCM8 84515 224320_s_at 1.9713 0.0001
GSE77861 MCM8 84515 224320_s_at 0.9367 0.0346
GSE97050 MCM8 84515 A_23_P68547 0.8871 0.1214
SRP007169 MCM8 84515 RNAseq 1.3965 0.0063
SRP008496 MCM8 84515 RNAseq 1.9640 0.0000
SRP064894 MCM8 84515 RNAseq 1.1355 0.0001
SRP133303 MCM8 84515 RNAseq 1.0701 0.0000
SRP159526 MCM8 84515 RNAseq 1.4655 0.0000
SRP193095 MCM8 84515 RNAseq 0.8078 0.0000
SRP219564 MCM8 84515 RNAseq 1.4252 0.0000
TCGA MCM8 84515 RNAseq 0.4672 0.0000

Upregulated datasets: 12; Downregulated datasets: 0.  

 

Survival by MCM8 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MCM8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MCM8 84515 11 2 17
GSE20123 MCM8 84515 11 2 17
GSE43470 MCM8 84515 12 1 30
GSE46452 MCM8 84515 26 1 32
GSE47630 MCM8 84515 18 4 18
GSE54993 MCM8 84515 1 14 55
GSE54994 MCM8 84515 25 2 26
GSE60625 MCM8 84515 0 0 11
GSE74703 MCM8 84515 9 1 26
GSE74704 MCM8 84515 5 1 14
TCGA MCM8 84515 40 11 45

Total number of gains: 158; Total number of losses: 39; Total Number of normals: 291.  

 

Somatic mutations of MCM8:

 

Generating mutation plots.

 

Highly correlated genes for MCM8:

 

Showing top 20/1491 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MCM8C18orf540.805295606
MCM8GINS10.796051808
MCM8MRGBP0.781999606
MCM8KNTC10.767554808
MCM8MTERF30.767332404
MCM8UBE2C0.766619808
MCM8BLM0.76438808
MCM8BRCA10.76366808
MCM8FADS10.763636303
MCM8MCM60.759266808
MCM8DNMT10.758778808
MCM8PYCR20.75715303
MCM8RPN20.754245707
MCM8SAC3D10.7504606
MCM8DNAJC20.748911707
MCM8KIF150.748296707
MCM8DTL0.746771808
MCM8AUNIP0.746517707
MCM8SEL1L30.744892303
MCM8ZBTB90.742739404

For details and further investigation, click here