SMARCB1

 

Full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Alias Symbol: BAF47|Ini1|Snr1|hSNFS|Sfh1p|RDT|PPP1R144|SNF5
Type: protein-coding gene Cytoband: 22q11.23
Entrez ID: 6598 HGNC ID: HGNC:11103 Ensembl Gene: ENSG00000099956 OMIM ID: 601607
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 162/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SMARCB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SMARCB1 6598 212167_s_at 0.5200 0.1306
GSE20347 SMARCB1 6598 212167_s_at 0.2838 0.0163
GSE23400 SMARCB1 6598 212167_s_at 0.2181 0.0000
GSE26886 SMARCB1 6598 212167_s_at 0.4396 0.0046
GSE29001 SMARCB1 6598 212167_s_at -0.1159 0.3216
GSE38129 SMARCB1 6598 212167_s_at 0.4885 0.0002
GSE45670 SMARCB1 6598 212167_s_at 0.2241 0.0687
GSE53622 SMARCB1 6598 35808 0.5261 0.0000
GSE53624 SMARCB1 6598 45978 0.5560 0.0000
GSE63941 SMARCB1 6598 212167_s_at 1.2048 0.0119
GSE77861 SMARCB1 6598 212167_s_at 0.2997 0.1340
GSE97050 SMARCB1 6598 A_33_P3343073 0.4860 0.2115
SRP007169 SMARCB1 6598 RNAseq 0.7488 0.0650
SRP008496 SMARCB1 6598 RNAseq 0.6194 0.0228
SRP064894 SMARCB1 6598 RNAseq 0.9176 0.0001
SRP133303 SMARCB1 6598 RNAseq 0.3783 0.0572
SRP159526 SMARCB1 6598 RNAseq 0.6950 0.0169
SRP193095 SMARCB1 6598 RNAseq 0.4448 0.0003
SRP219564 SMARCB1 6598 RNAseq 0.8983 0.0027
TCGA SMARCB1 6598 RNAseq 0.1681 0.0005

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by SMARCB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SMARCB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SMARCB1 6598 5 7 18
GSE20123 SMARCB1 6598 5 6 19
GSE43470 SMARCB1 6598 3 6 34
GSE46452 SMARCB1 6598 32 1 26
GSE47630 SMARCB1 6598 8 5 27
GSE54993 SMARCB1 6598 3 6 61
GSE54994 SMARCB1 6598 11 7 35
GSE60625 SMARCB1 6598 5 0 6
GSE74703 SMARCB1 6598 3 5 28
GSE74704 SMARCB1 6598 2 3 15
TCGA SMARCB1 6598 26 15 55

Total number of gains: 103; Total number of losses: 61; Total Number of normals: 324.  

 

Somatic mutations of SMARCB1:

 

Generating mutation plots.

 

Highly correlated genes for SMARCB1:

 

Showing top 20/326 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SMARCB1IPO130.763538303
SMARCB1ZNF6780.746436303
SMARCB1FMNL10.735302303
SMARCB1LINC012340.720716303
SMARCB1LRWD10.718187303
SMARCB1EDARADD0.715627303
SMARCB1TMEM120B0.707605303
SMARCB1CHST100.697889303
SMARCB1BOP10.683162303
SMARCB1FBRSL10.681966404
SMARCB1C19orf480.679334303
SMARCB1TBC1D70.673444403
SMARCB1WRAP730.672792504
SMARCB1PRR180.667244303
SMARCB1YDJC0.666657906
SMARCB1ALDH16A10.66049503
SMARCB1NPW0.645485303
SMARCB1CDK160.64485605
SMARCB1RCC20.641469504
SMARCB1CCDC1670.638082403

For details and further investigation, click here