| Full name: structural maintenance of chromosomes flexible hinge domain containing 1 | Alias Symbol: KIAA0650|FSHD2 | ||
| Type: protein-coding gene | Cytoband: 18p11.32 | ||
| Entrez ID: 23347 | HGNC ID: HGNC:29090 | Ensembl Gene: ENSG00000101596 | OMIM ID: 614982 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SMCHD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMCHD1 | 23347 | 212569_at | 0.4316 | 0.3654 | |
| GSE20347 | SMCHD1 | 23347 | 212579_at | 0.6816 | 0.0009 | |
| GSE23400 | SMCHD1 | 23347 | 212577_at | 0.5673 | 0.0000 | |
| GSE26886 | SMCHD1 | 23347 | 212569_at | 0.3989 | 0.1537 | |
| GSE29001 | SMCHD1 | 23347 | 212569_at | 0.9749 | 0.0073 | |
| GSE38129 | SMCHD1 | 23347 | 212579_at | 0.3859 | 0.0169 | |
| GSE45670 | SMCHD1 | 23347 | 212569_at | 0.2216 | 0.2851 | |
| GSE53622 | SMCHD1 | 23347 | 34289 | 0.2920 | 0.0004 | |
| GSE53624 | SMCHD1 | 23347 | 34289 | 0.2257 | 0.0003 | |
| GSE63941 | SMCHD1 | 23347 | 212569_at | 0.2044 | 0.7667 | |
| GSE77861 | SMCHD1 | 23347 | 212577_at | 0.6145 | 0.0812 | |
| GSE97050 | SMCHD1 | 23347 | A_23_P38723 | 0.3104 | 0.3130 | |
| SRP007169 | SMCHD1 | 23347 | RNAseq | 1.4655 | 0.0001 | |
| SRP008496 | SMCHD1 | 23347 | RNAseq | 1.4459 | 0.0000 | |
| SRP064894 | SMCHD1 | 23347 | RNAseq | 0.4514 | 0.1970 | |
| SRP133303 | SMCHD1 | 23347 | RNAseq | 0.5303 | 0.0005 | |
| SRP159526 | SMCHD1 | 23347 | RNAseq | 0.1371 | 0.6270 | |
| SRP193095 | SMCHD1 | 23347 | RNAseq | 0.3783 | 0.0007 | |
| SRP219564 | SMCHD1 | 23347 | RNAseq | 0.0377 | 0.8799 | |
| TCGA | SMCHD1 | 23347 | RNAseq | -0.0026 | 0.9618 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SMCHD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMCHD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMCHD1 | 23347 | 7 | 2 | 21 | |
| GSE20123 | SMCHD1 | 23347 | 7 | 2 | 21 | |
| GSE43470 | SMCHD1 | 23347 | 2 | 5 | 36 | |
| GSE46452 | SMCHD1 | 23347 | 3 | 20 | 36 | |
| GSE47630 | SMCHD1 | 23347 | 7 | 18 | 15 | |
| GSE54993 | SMCHD1 | 23347 | 6 | 3 | 61 | |
| GSE54994 | SMCHD1 | 23347 | 12 | 8 | 33 | |
| GSE60625 | SMCHD1 | 23347 | 0 | 4 | 7 | |
| GSE74703 | SMCHD1 | 23347 | 2 | 3 | 31 | |
| GSE74704 | SMCHD1 | 23347 | 5 | 2 | 13 | |
| TCGA | SMCHD1 | 23347 | 36 | 17 | 43 |
Total number of gains: 87; Total number of losses: 84; Total Number of normals: 317.
Somatic mutations of SMCHD1:
Generating mutation plots.
Highly correlated genes for SMCHD1:
Showing top 20/880 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMCHD1 | NUP35 | 0.826351 | 3 | 0 | 3 |
| SMCHD1 | ZNF200 | 0.724393 | 3 | 0 | 3 |
| SMCHD1 | CCS | 0.716529 | 3 | 0 | 3 |
| SMCHD1 | BBS7 | 0.716211 | 3 | 0 | 3 |
| SMCHD1 | LTV1 | 0.71275 | 3 | 0 | 3 |
| SMCHD1 | RIN3 | 0.70503 | 3 | 0 | 3 |
| SMCHD1 | TMEM181 | 0.702769 | 3 | 0 | 3 |
| SMCHD1 | CMTM4 | 0.701369 | 3 | 0 | 3 |
| SMCHD1 | MGAT5 | 0.698437 | 4 | 0 | 3 |
| SMCHD1 | ZNF251 | 0.694347 | 3 | 0 | 3 |
| SMCHD1 | GCLC | 0.692745 | 3 | 0 | 3 |
| SMCHD1 | PGM2L1 | 0.683705 | 4 | 0 | 3 |
| SMCHD1 | MRPL32 | 0.682223 | 3 | 0 | 3 |
| SMCHD1 | GTF3C4 | 0.681155 | 3 | 0 | 3 |
| SMCHD1 | WDR75 | 0.676605 | 4 | 0 | 3 |
| SMCHD1 | CNTNAP2 | 0.674061 | 3 | 0 | 3 |
| SMCHD1 | GTF3C3 | 0.672865 | 5 | 0 | 5 |
| SMCHD1 | SPCS2 | 0.672392 | 4 | 0 | 3 |
| SMCHD1 | IL17RD | 0.67042 | 3 | 0 | 3 |
| SMCHD1 | EIF5 | 0.668558 | 3 | 0 | 3 |
For details and further investigation, click here
