| Full name: aldehyde dehydrogenase 6 family member A1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 4329 | HGNC ID: HGNC:7179 | Ensembl Gene: ENSG00000119711 | OMIM ID: 603178 |
| Drug and gene relationship at DGIdb | |||
Expression of ALDH6A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH6A1 | 4329 | 221588_x_at | -0.8270 | 0.1930 | |
| GSE20347 | ALDH6A1 | 4329 | 221588_x_at | -0.7570 | 0.0017 | |
| GSE23400 | ALDH6A1 | 4329 | 221588_x_at | -0.3461 | 0.0001 | |
| GSE26886 | ALDH6A1 | 4329 | 221589_s_at | -0.3113 | 0.3188 | |
| GSE29001 | ALDH6A1 | 4329 | 221589_s_at | -0.9455 | 0.0227 | |
| GSE38129 | ALDH6A1 | 4329 | 221589_s_at | -1.1232 | 0.0000 | |
| GSE45670 | ALDH6A1 | 4329 | 221589_s_at | -1.0963 | 0.0000 | |
| GSE53622 | ALDH6A1 | 4329 | 1635 | -0.7484 | 0.0000 | |
| GSE53624 | ALDH6A1 | 4329 | 1635 | -0.8451 | 0.0000 | |
| GSE63941 | ALDH6A1 | 4329 | 221589_s_at | -0.3564 | 0.6276 | |
| GSE77861 | ALDH6A1 | 4329 | 204290_s_at | -0.7712 | 0.0425 | |
| GSE97050 | ALDH6A1 | 4329 | A_23_P128967 | -0.2047 | 0.5993 | |
| SRP007169 | ALDH6A1 | 4329 | RNAseq | -0.8901 | 0.0047 | |
| SRP008496 | ALDH6A1 | 4329 | RNAseq | -1.0175 | 0.0008 | |
| SRP064894 | ALDH6A1 | 4329 | RNAseq | -0.7119 | 0.0000 | |
| SRP133303 | ALDH6A1 | 4329 | RNAseq | -0.6117 | 0.0002 | |
| SRP159526 | ALDH6A1 | 4329 | RNAseq | -0.6311 | 0.0294 | |
| SRP193095 | ALDH6A1 | 4329 | RNAseq | -0.8097 | 0.0000 | |
| SRP219564 | ALDH6A1 | 4329 | RNAseq | -0.7847 | 0.0036 | |
| TCGA | ALDH6A1 | 4329 | RNAseq | -0.7423 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ALDH6A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH6A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH6A1 | 4329 | 8 | 2 | 20 | |
| GSE20123 | ALDH6A1 | 4329 | 8 | 2 | 20 | |
| GSE43470 | ALDH6A1 | 4329 | 8 | 3 | 32 | |
| GSE46452 | ALDH6A1 | 4329 | 16 | 3 | 40 | |
| GSE47630 | ALDH6A1 | 4329 | 11 | 8 | 21 | |
| GSE54993 | ALDH6A1 | 4329 | 3 | 8 | 59 | |
| GSE54994 | ALDH6A1 | 4329 | 19 | 4 | 30 | |
| GSE60625 | ALDH6A1 | 4329 | 0 | 2 | 9 | |
| GSE74703 | ALDH6A1 | 4329 | 7 | 3 | 26 | |
| GSE74704 | ALDH6A1 | 4329 | 3 | 2 | 15 | |
| TCGA | ALDH6A1 | 4329 | 32 | 16 | 48 |
Total number of gains: 115; Total number of losses: 53; Total Number of normals: 320.
Somatic mutations of ALDH6A1:
Generating mutation plots.
Highly correlated genes for ALDH6A1:
Showing top 20/1063 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH6A1 | ZNF407 | 0.760729 | 3 | 0 | 3 |
| ALDH6A1 | CNST | 0.760343 | 3 | 0 | 3 |
| ALDH6A1 | FBXL3 | 0.755029 | 4 | 0 | 4 |
| ALDH6A1 | RNF207 | 0.753547 | 3 | 0 | 3 |
| ALDH6A1 | ICA1L | 0.745724 | 4 | 0 | 4 |
| ALDH6A1 | ZBTB10 | 0.74298 | 3 | 0 | 3 |
| ALDH6A1 | PDCD4 | 0.742465 | 4 | 0 | 4 |
| ALDH6A1 | TET2 | 0.738527 | 3 | 0 | 3 |
| ALDH6A1 | ZNF548 | 0.729547 | 3 | 0 | 3 |
| ALDH6A1 | ZRANB1 | 0.727351 | 3 | 0 | 3 |
| ALDH6A1 | CLYBL | 0.718797 | 6 | 0 | 6 |
| ALDH6A1 | HDHD2 | 0.716827 | 4 | 0 | 3 |
| ALDH6A1 | BCLAF1 | 0.715012 | 4 | 0 | 4 |
| ALDH6A1 | TSNARE1 | 0.714435 | 3 | 0 | 3 |
| ALDH6A1 | PTCD2 | 0.710517 | 3 | 0 | 3 |
| ALDH6A1 | CIRBP | 0.709215 | 10 | 0 | 10 |
| ALDH6A1 | MTAP | 0.698759 | 3 | 0 | 3 |
| ALDH6A1 | SNCA | 0.694642 | 3 | 0 | 3 |
| ALDH6A1 | KLHDC1 | 0.692892 | 5 | 0 | 5 |
| ALDH6A1 | LRRK2 | 0.688531 | 5 | 0 | 5 |
For details and further investigation, click here
