SNRPA

 

Full name: small nuclear ribonucleoprotein polypeptide A Alias Symbol: U1A|U1-A|Mud1
Type: protein-coding gene Cytoband: 19q13.1
Entrez ID: 6626 HGNC ID: HGNC:11151 Ensembl Gene: ENSG00000077312 OMIM ID: 182285
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SNRPA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SNRPA 6626 201770_at 0.6947 0.0456
GSE20347 SNRPA 6626 201770_at 0.5591 0.0000
GSE23400 SNRPA 6626 201770_at 0.5330 0.0000
GSE26886 SNRPA 6626 201770_at 1.0811 0.0001
GSE29001 SNRPA 6626 201770_at 0.5076 0.1035
GSE38129 SNRPA 6626 201770_at 0.5247 0.0000
GSE45670 SNRPA 6626 201770_at 0.1930 0.2768
GSE53622 SNRPA 6626 85841 0.2160 0.0001
GSE53624 SNRPA 6626 85841 0.4569 0.0000
GSE63941 SNRPA 6626 201770_at 2.1376 0.0000
GSE77861 SNRPA 6626 201770_at 0.5420 0.0496
GSE97050 SNRPA 6626 A_24_P250335 0.4247 0.2066
SRP007169 SNRPA 6626 RNAseq 0.2117 0.4968
SRP008496 SNRPA 6626 RNAseq 0.0131 0.9491
SRP064894 SNRPA 6626 RNAseq 0.6027 0.0145
SRP133303 SNRPA 6626 RNAseq 0.3220 0.0333
SRP159526 SNRPA 6626 RNAseq 0.4761 0.1670
SRP193095 SNRPA 6626 RNAseq 0.2192 0.0112
SRP219564 SNRPA 6626 RNAseq 0.5082 0.1256
TCGA SNRPA 6626 RNAseq 0.2435 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by SNRPA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SNRPA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SNRPA 6626 5 5 20
GSE20123 SNRPA 6626 5 4 21
GSE43470 SNRPA 6626 3 9 31
GSE46452 SNRPA 6626 48 1 10
GSE47630 SNRPA 6626 9 5 26
GSE54993 SNRPA 6626 17 4 49
GSE54994 SNRPA 6626 8 9 36
GSE60625 SNRPA 6626 9 0 2
GSE74703 SNRPA 6626 3 6 27
GSE74704 SNRPA 6626 5 2 13
TCGA SNRPA 6626 14 16 66

Total number of gains: 126; Total number of losses: 61; Total Number of normals: 301.  

 

Somatic mutations of SNRPA:

 

Generating mutation plots.

 

Highly correlated genes for SNRPA:

 

Showing top 20/1812 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SNRPATRAPPC10.866608303
SNRPAGAS2L10.792349303
SNRPACOMMD70.792119303
SNRPASLC39A30.772309404
SNRPADNAJC90.754313707
SNRPAADAM150.743634303
SNRPAMCM30.74014411011
SNRPADNMT10.73877912012
SNRPATRIM280.73794213013
SNRPARAVER10.736554706
SNRPAGPR1600.733682303
SNRPAMCM60.72968511011
SNRPAEFTUD20.728757808
SNRPAPDCD2L0.728593504
SNRPAUBE2T0.727683808
SNRPATMEM540.727583303
SNRPALSM70.72473511011
SNRPAC12orf490.72261303
SNRPABANF10.72228613012
SNRPAC12orf450.722215606

For details and further investigation, click here