| Full name: spermidine synthase | Alias Symbol: SPS1 | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 6723 | HGNC ID: HGNC:11296 | Ensembl Gene: ENSG00000116649 | OMIM ID: 182891 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SRM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRM | 6723 | 201516_at | 1.3558 | 0.0357 | |
| GSE20347 | SRM | 6723 | 201516_at | 0.5336 | 0.0229 | |
| GSE23400 | SRM | 6723 | 201516_at | 0.6750 | 0.0000 | |
| GSE26886 | SRM | 6723 | 201516_at | 0.3686 | 0.2022 | |
| GSE29001 | SRM | 6723 | 201516_at | 0.5344 | 0.0833 | |
| GSE38129 | SRM | 6723 | 201516_at | 0.6544 | 0.0001 | |
| GSE45670 | SRM | 6723 | 201516_at | 0.5385 | 0.0142 | |
| GSE53622 | SRM | 6723 | 94725 | 0.6951 | 0.0000 | |
| GSE53624 | SRM | 6723 | 94725 | 1.0136 | 0.0000 | |
| GSE63941 | SRM | 6723 | 201516_at | -0.2934 | 0.6203 | |
| GSE77861 | SRM | 6723 | 201516_at | 0.2141 | 0.4514 | |
| GSE97050 | SRM | 6723 | A_23_P74269 | 1.1347 | 0.0866 | |
| SRP007169 | SRM | 6723 | RNAseq | 0.8093 | 0.1383 | |
| SRP008496 | SRM | 6723 | RNAseq | 0.9849 | 0.0071 | |
| SRP064894 | SRM | 6723 | RNAseq | 1.2388 | 0.0002 | |
| SRP133303 | SRM | 6723 | RNAseq | 0.9626 | 0.0000 | |
| SRP159526 | SRM | 6723 | RNAseq | 0.7732 | 0.0156 | |
| SRP193095 | SRM | 6723 | RNAseq | 0.7578 | 0.0000 | |
| SRP219564 | SRM | 6723 | RNAseq | 0.9506 | 0.0505 | |
| TCGA | SRM | 6723 | RNAseq | 0.1874 | 0.0019 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SRM expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRM | 6723 | 0 | 5 | 25 | |
| GSE20123 | SRM | 6723 | 0 | 4 | 26 | |
| GSE43470 | SRM | 6723 | 6 | 5 | 32 | |
| GSE46452 | SRM | 6723 | 7 | 1 | 51 | |
| GSE47630 | SRM | 6723 | 8 | 4 | 28 | |
| GSE54993 | SRM | 6723 | 3 | 1 | 66 | |
| GSE54994 | SRM | 6723 | 11 | 4 | 38 | |
| GSE60625 | SRM | 6723 | 0 | 0 | 11 | |
| GSE74703 | SRM | 6723 | 5 | 3 | 28 | |
| GSE74704 | SRM | 6723 | 0 | 0 | 20 | |
| TCGA | SRM | 6723 | 10 | 22 | 64 |
Total number of gains: 50; Total number of losses: 49; Total Number of normals: 389.
Somatic mutations of SRM:
Generating mutation plots.
Highly correlated genes for SRM:
Showing top 20/1813 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRM | LRRC8C | 0.773825 | 3 | 0 | 3 |
| SRM | EBNA1BP2 | 0.765428 | 3 | 0 | 3 |
| SRM | NOP56 | 0.746087 | 3 | 0 | 3 |
| SRM | FAM89A | 0.745452 | 3 | 0 | 3 |
| SRM | PDIA5 | 0.731559 | 3 | 0 | 3 |
| SRM | KDM1A | 0.73038 | 10 | 0 | 10 |
| SRM | PYCR2 | 0.728518 | 3 | 0 | 3 |
| SRM | MRPS12 | 0.727038 | 7 | 0 | 7 |
| SRM | PSMB2 | 0.725634 | 10 | 0 | 10 |
| SRM | ROMO1 | 0.724811 | 3 | 0 | 3 |
| SRM | ZNF670 | 0.722727 | 3 | 0 | 3 |
| SRM | ABCF1 | 0.722048 | 9 | 0 | 9 |
| SRM | PRR12 | 0.720057 | 3 | 0 | 3 |
| SRM | KTI12 | 0.718531 | 3 | 0 | 3 |
| SRM | SSBP4 | 0.717416 | 3 | 0 | 3 |
| SRM | FCGR3A | 0.712559 | 3 | 0 | 3 |
| SRM | UBIAD1 | 0.704705 | 10 | 0 | 10 |
| SRM | NOTCH3 | 0.704408 | 3 | 0 | 3 |
| SRM | UTP23 | 0.704396 | 5 | 0 | 5 |
| SRM | KRTCAP2 | 0.703384 | 5 | 0 | 5 |
For details and further investigation, click here
