| Full name: lysine demethylase 1A | Alias Symbol: KIAA0601|BHC110|LSD1 | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 23028 | HGNC ID: HGNC:29079 | Ensembl Gene: ENSG00000004487 | OMIM ID: 609132 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KDM1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KDM1A | 23028 | 212348_s_at | 0.7588 | 0.0247 | |
| GSE20347 | KDM1A | 23028 | 212348_s_at | 0.4934 | 0.0014 | |
| GSE23400 | KDM1A | 23028 | 212348_s_at | 0.5902 | 0.0000 | |
| GSE26886 | KDM1A | 23028 | 212348_s_at | -0.1061 | 0.7563 | |
| GSE29001 | KDM1A | 23028 | 212348_s_at | 0.5524 | 0.1090 | |
| GSE38129 | KDM1A | 23028 | 212348_s_at | 0.5807 | 0.0000 | |
| GSE45670 | KDM1A | 23028 | 212348_s_at | 0.4508 | 0.0031 | |
| GSE53622 | KDM1A | 23028 | 82528 | 0.9687 | 0.0000 | |
| GSE53624 | KDM1A | 23028 | 82528 | 0.8082 | 0.0000 | |
| GSE63941 | KDM1A | 23028 | 212348_s_at | 0.6082 | 0.2039 | |
| GSE77861 | KDM1A | 23028 | 212348_s_at | 0.3940 | 0.1971 | |
| GSE97050 | KDM1A | 23028 | A_24_P74981 | 0.7853 | 0.0728 | |
| SRP007169 | KDM1A | 23028 | RNAseq | 1.9153 | 0.0008 | |
| SRP008496 | KDM1A | 23028 | RNAseq | 1.5703 | 0.0000 | |
| SRP064894 | KDM1A | 23028 | RNAseq | 0.9023 | 0.0000 | |
| SRP133303 | KDM1A | 23028 | RNAseq | 0.7789 | 0.0003 | |
| SRP159526 | KDM1A | 23028 | RNAseq | 0.8708 | 0.0051 | |
| SRP193095 | KDM1A | 23028 | RNAseq | 0.6262 | 0.0000 | |
| SRP219564 | KDM1A | 23028 | RNAseq | 0.4728 | 0.1495 | |
| TCGA | KDM1A | 23028 | RNAseq | 0.2176 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by KDM1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KDM1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KDM1A | 23028 | 0 | 5 | 25 | |
| GSE20123 | KDM1A | 23028 | 0 | 4 | 26 | |
| GSE43470 | KDM1A | 23028 | 2 | 6 | 35 | |
| GSE46452 | KDM1A | 23028 | 5 | 1 | 53 | |
| GSE47630 | KDM1A | 23028 | 8 | 3 | 29 | |
| GSE54993 | KDM1A | 23028 | 2 | 1 | 67 | |
| GSE54994 | KDM1A | 23028 | 11 | 4 | 38 | |
| GSE60625 | KDM1A | 23028 | 0 | 0 | 11 | |
| GSE74703 | KDM1A | 23028 | 1 | 4 | 31 | |
| GSE74704 | KDM1A | 23028 | 0 | 0 | 20 | |
| TCGA | KDM1A | 23028 | 9 | 23 | 64 |
Total number of gains: 38; Total number of losses: 51; Total Number of normals: 399.
Somatic mutations of KDM1A:
Generating mutation plots.
Highly correlated genes for KDM1A:
Showing top 20/2020 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KDM1A | ALG1 | 0.791883 | 3 | 0 | 3 |
| KDM1A | MRPL47 | 0.768944 | 5 | 0 | 5 |
| KDM1A | SIX4 | 0.768884 | 6 | 0 | 5 |
| KDM1A | MAD2L2 | 0.768568 | 7 | 0 | 7 |
| KDM1A | EBNA1BP2 | 0.768189 | 3 | 0 | 3 |
| KDM1A | TRAF7 | 0.762962 | 3 | 0 | 3 |
| KDM1A | MCU | 0.755965 | 3 | 0 | 3 |
| KDM1A | LRRC58 | 0.755667 | 3 | 0 | 3 |
| KDM1A | RAB34 | 0.751307 | 3 | 0 | 3 |
| KDM1A | GMNN | 0.751137 | 9 | 0 | 8 |
| KDM1A | PMS2 | 0.749772 | 3 | 0 | 3 |
| KDM1A | PLOD1 | 0.747823 | 10 | 0 | 10 |
| KDM1A | PYCR2 | 0.747806 | 3 | 0 | 3 |
| KDM1A | NEDD1 | 0.743062 | 6 | 0 | 6 |
| KDM1A | SLC35B2 | 0.742141 | 3 | 0 | 3 |
| KDM1A | MTBP | 0.741841 | 5 | 0 | 5 |
| KDM1A | SCNM1 | 0.740486 | 3 | 0 | 3 |
| KDM1A | NTMT1 | 0.74009 | 4 | 0 | 4 |
| KDM1A | NEK2 | 0.738419 | 9 | 0 | 9 |
| KDM1A | PACS1 | 0.737745 | 3 | 0 | 3 |
For details and further investigation, click here
