| Full name: SRP receptor subunit beta | Alias Symbol: APMCF1|SR-beta | ||
| Type: protein-coding gene | Cytoband: 3q22.1 | ||
| Entrez ID: 58477 | HGNC ID: HGNC:24085 | Ensembl Gene: ENSG00000144867 | OMIM ID: 616883 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SRPRB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRPRB | 58477 | 218140_x_at | 0.6204 | 0.1383 | |
| GSE20347 | SRPRB | 58477 | 218140_x_at | 0.3792 | 0.0299 | |
| GSE23400 | SRPRB | 58477 | 218140_x_at | 0.6234 | 0.0000 | |
| GSE26886 | SRPRB | 58477 | 218140_x_at | -0.4484 | 0.0504 | |
| GSE29001 | SRPRB | 58477 | 218140_x_at | 0.5294 | 0.1556 | |
| GSE38129 | SRPRB | 58477 | 218140_x_at | 0.6070 | 0.0016 | |
| GSE45670 | SRPRB | 58477 | 218140_x_at | 0.4440 | 0.0268 | |
| GSE53622 | SRPRB | 58477 | 297 | 0.3823 | 0.0000 | |
| GSE53624 | SRPRB | 58477 | 297 | 0.3377 | 0.0000 | |
| GSE63941 | SRPRB | 58477 | 218140_x_at | -0.3656 | 0.3777 | |
| GSE77861 | SRPRB | 58477 | 218140_x_at | -0.2963 | 0.3673 | |
| GSE97050 | SRPRB | 58477 | A_23_P80773 | 0.7315 | 0.2275 | |
| SRP007169 | SRPRB | 58477 | RNAseq | 0.0447 | 0.8877 | |
| SRP008496 | SRPRB | 58477 | RNAseq | 0.1074 | 0.6178 | |
| SRP064894 | SRPRB | 58477 | RNAseq | 0.5166 | 0.0293 | |
| SRP133303 | SRPRB | 58477 | RNAseq | 0.5137 | 0.0000 | |
| SRP159526 | SRPRB | 58477 | RNAseq | 0.6703 | 0.0300 | |
| SRP193095 | SRPRB | 58477 | RNAseq | 0.0197 | 0.8849 | |
| SRP219564 | SRPRB | 58477 | RNAseq | 0.6230 | 0.1148 | |
| TCGA | SRPRB | 58477 | RNAseq | 0.0493 | 0.3671 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRPRB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRPRB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRPRB | 58477 | 16 | 0 | 14 | |
| GSE20123 | SRPRB | 58477 | 16 | 0 | 14 | |
| GSE43470 | SRPRB | 58477 | 21 | 0 | 22 | |
| GSE46452 | SRPRB | 58477 | 15 | 4 | 40 | |
| GSE47630 | SRPRB | 58477 | 18 | 3 | 19 | |
| GSE54993 | SRPRB | 58477 | 2 | 8 | 60 | |
| GSE54994 | SRPRB | 58477 | 32 | 1 | 20 | |
| GSE60625 | SRPRB | 58477 | 0 | 6 | 5 | |
| GSE74703 | SRPRB | 58477 | 18 | 0 | 18 | |
| GSE74704 | SRPRB | 58477 | 11 | 0 | 9 | |
| TCGA | SRPRB | 58477 | 59 | 5 | 32 |
Total number of gains: 208; Total number of losses: 27; Total Number of normals: 253.
Somatic mutations of SRPRB:
Generating mutation plots.
Highly correlated genes for SRPRB:
Showing top 20/560 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRPRB | RNF149 | 0.752584 | 3 | 0 | 3 |
| SRPRB | ALG1 | 0.749593 | 3 | 0 | 3 |
| SRPRB | AP1G1 | 0.730396 | 4 | 0 | 4 |
| SRPRB | LACTB | 0.730393 | 3 | 0 | 3 |
| SRPRB | PPWD1 | 0.72873 | 3 | 0 | 3 |
| SRPRB | SRRD | 0.722882 | 4 | 0 | 4 |
| SRPRB | PSPC1 | 0.709636 | 4 | 0 | 4 |
| SRPRB | MARS2 | 0.703979 | 4 | 0 | 3 |
| SRPRB | CALML5 | 0.703124 | 3 | 0 | 3 |
| SRPRB | ZNF267 | 0.687867 | 4 | 0 | 4 |
| SRPRB | AFTPH | 0.682389 | 3 | 0 | 3 |
| SRPRB | ATR | 0.682102 | 9 | 0 | 7 |
| SRPRB | RNGTT | 0.681174 | 3 | 0 | 3 |
| SRPRB | DSE | 0.68072 | 3 | 0 | 3 |
| SRPRB | STX4 | 0.674691 | 3 | 0 | 3 |
| SRPRB | TOPBP1 | 0.674531 | 10 | 0 | 9 |
| SRPRB | ALDH5A1 | 0.673879 | 4 | 0 | 3 |
| SRPRB | WTAP | 0.668549 | 3 | 0 | 3 |
| SRPRB | SLC30A7 | 0.667958 | 3 | 0 | 3 |
| SRPRB | B4GALT5 | 0.66784 | 3 | 0 | 3 |
For details and further investigation, click here
