| Full name: shisa family member 5 | Alias Symbol: SCOTIN|hShisa5 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 51246 | HGNC ID: HGNC:30376 | Ensembl Gene: ENSG00000164054 | OMIM ID: 607290 |
| Drug and gene relationship at DGIdb | |||
SHISA5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway |
Expression of SHISA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHISA5 | 51246 | 222986_s_at | 0.1678 | 0.7992 | |
| GSE26886 | SHISA5 | 51246 | 222986_s_at | -0.6003 | 0.0200 | |
| GSE45670 | SHISA5 | 51246 | 222986_s_at | 0.5537 | 0.0029 | |
| GSE53622 | SHISA5 | 51246 | 42194 | -0.5539 | 0.0000 | |
| GSE53624 | SHISA5 | 51246 | 42194 | -0.3103 | 0.0000 | |
| GSE63941 | SHISA5 | 51246 | 222986_s_at | 0.0368 | 0.9396 | |
| GSE77861 | SHISA5 | 51246 | 222986_s_at | -0.0835 | 0.7751 | |
| GSE97050 | SHISA5 | 51246 | A_33_P3270636 | 0.2704 | 0.2464 | |
| SRP007169 | SHISA5 | 51246 | RNAseq | 0.4108 | 0.3322 | |
| SRP008496 | SHISA5 | 51246 | RNAseq | 0.2025 | 0.4370 | |
| SRP064894 | SHISA5 | 51246 | RNAseq | 0.6907 | 0.0037 | |
| SRP133303 | SHISA5 | 51246 | RNAseq | -0.1251 | 0.4940 | |
| SRP159526 | SHISA5 | 51246 | RNAseq | -0.4982 | 0.1473 | |
| SRP193095 | SHISA5 | 51246 | RNAseq | 0.0446 | 0.7297 | |
| SRP219564 | SHISA5 | 51246 | RNAseq | -0.0337 | 0.9184 | |
| TCGA | SHISA5 | 51246 | RNAseq | 0.0938 | 0.0334 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SHISA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHISA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHISA5 | 51246 | 0 | 18 | 12 | |
| GSE20123 | SHISA5 | 51246 | 0 | 19 | 11 | |
| GSE43470 | SHISA5 | 51246 | 0 | 19 | 24 | |
| GSE46452 | SHISA5 | 51246 | 2 | 17 | 40 | |
| GSE47630 | SHISA5 | 51246 | 1 | 24 | 15 | |
| GSE54993 | SHISA5 | 51246 | 6 | 2 | 62 | |
| GSE54994 | SHISA5 | 51246 | 0 | 36 | 17 | |
| GSE60625 | SHISA5 | 51246 | 5 | 0 | 6 | |
| GSE74703 | SHISA5 | 51246 | 0 | 15 | 21 | |
| GSE74704 | SHISA5 | 51246 | 0 | 12 | 8 | |
| TCGA | SHISA5 | 51246 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 240; Total Number of normals: 234.
Somatic mutations of SHISA5:
Generating mutation plots.
Highly correlated genes for SHISA5:
Showing top 20/215 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHISA5 | MAN2B2 | 0.840298 | 3 | 0 | 3 |
| SHISA5 | SLC25A38 | 0.787467 | 3 | 0 | 3 |
| SHISA5 | MRFAP1L1 | 0.743383 | 3 | 0 | 3 |
| SHISA5 | LDLRAP1 | 0.737478 | 3 | 0 | 3 |
| SHISA5 | GAS6 | 0.736328 | 3 | 0 | 3 |
| SHISA5 | TRIAP1 | 0.735236 | 3 | 0 | 3 |
| SHISA5 | ARMC8 | 0.732976 | 3 | 0 | 3 |
| SHISA5 | AP3S1 | 0.729466 | 3 | 0 | 3 |
| SHISA5 | STAT6 | 0.713622 | 3 | 0 | 3 |
| SHISA5 | CLIP1 | 0.713168 | 3 | 0 | 3 |
| SHISA5 | C6orf62 | 0.709936 | 3 | 0 | 3 |
| SHISA5 | RPRD2 | 0.709589 | 3 | 0 | 3 |
| SHISA5 | MS4A6A | 0.70511 | 3 | 0 | 3 |
| SHISA5 | DNAJC3 | 0.701247 | 3 | 0 | 3 |
| SHISA5 | BTN3A2 | 0.697484 | 3 | 0 | 3 |
| SHISA5 | USP4 | 0.695729 | 4 | 0 | 4 |
| SHISA5 | CAPN3 | 0.695119 | 3 | 0 | 3 |
| SHISA5 | STX6 | 0.692902 | 3 | 0 | 3 |
| SHISA5 | SNRNP35 | 0.691607 | 3 | 0 | 3 |
| SHISA5 | SARS2 | 0.690449 | 3 | 0 | 3 |
For details and further investigation, click here
