| Full name: STEAP family member 1 | Alias Symbol: PRSS24 | ||
| Type: protein-coding gene | Cytoband: 7q21.13 | ||
| Entrez ID: 26872 | HGNC ID: HGNC:11378 | Ensembl Gene: ENSG00000164647 | OMIM ID: 604415 |
| Drug and gene relationship at DGIdb | |||
Expression of STEAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STEAP1 | 26872 | 205542_at | 0.2374 | 0.8916 | |
| GSE20347 | STEAP1 | 26872 | 205542_at | 0.6948 | 0.0060 | |
| GSE23400 | STEAP1 | 26872 | 205542_at | 0.8640 | 0.0000 | |
| GSE26886 | STEAP1 | 26872 | 205542_at | 1.3795 | 0.0074 | |
| GSE29001 | STEAP1 | 26872 | 205542_at | 0.1409 | 0.7817 | |
| GSE38129 | STEAP1 | 26872 | 205542_at | 0.9841 | 0.0000 | |
| GSE45670 | STEAP1 | 26872 | 205542_at | 0.5606 | 0.1373 | |
| GSE53622 | STEAP1 | 26872 | 7353 | 0.9012 | 0.0000 | |
| GSE53624 | STEAP1 | 26872 | 7353 | 0.7623 | 0.0000 | |
| GSE63941 | STEAP1 | 26872 | 205542_at | -1.4703 | 0.4254 | |
| GSE77861 | STEAP1 | 26872 | 205542_at | 1.0219 | 0.1355 | |
| GSE97050 | STEAP1 | 26872 | A_23_P31453 | 1.5179 | 0.0828 | |
| SRP007169 | STEAP1 | 26872 | RNAseq | 0.3179 | 0.4967 | |
| SRP008496 | STEAP1 | 26872 | RNAseq | 0.4816 | 0.2274 | |
| SRP064894 | STEAP1 | 26872 | RNAseq | 0.8487 | 0.0002 | |
| SRP133303 | STEAP1 | 26872 | RNAseq | 1.0636 | 0.0014 | |
| SRP159526 | STEAP1 | 26872 | RNAseq | 0.2690 | 0.5990 | |
| SRP193095 | STEAP1 | 26872 | RNAseq | 1.1071 | 0.0000 | |
| SRP219564 | STEAP1 | 26872 | RNAseq | 1.1369 | 0.0003 | |
| TCGA | STEAP1 | 26872 | RNAseq | 0.4255 | 0.0013 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by STEAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STEAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STEAP1 | 26872 | 13 | 1 | 16 | |
| GSE20123 | STEAP1 | 26872 | 13 | 0 | 17 | |
| GSE43470 | STEAP1 | 26872 | 6 | 1 | 36 | |
| GSE46452 | STEAP1 | 26872 | 11 | 0 | 48 | |
| GSE47630 | STEAP1 | 26872 | 9 | 2 | 29 | |
| GSE54993 | STEAP1 | 26872 | 1 | 8 | 61 | |
| GSE54994 | STEAP1 | 26872 | 17 | 2 | 34 | |
| GSE60625 | STEAP1 | 26872 | 0 | 0 | 11 | |
| GSE74703 | STEAP1 | 26872 | 5 | 1 | 30 | |
| GSE74704 | STEAP1 | 26872 | 9 | 0 | 11 | |
| TCGA | STEAP1 | 26872 | 55 | 5 | 36 |
Total number of gains: 139; Total number of losses: 20; Total Number of normals: 329.
Somatic mutations of STEAP1:
Generating mutation plots.
Highly correlated genes for STEAP1:
Showing top 20/766 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STEAP1 | SPPL2A | 0.789441 | 3 | 0 | 3 |
| STEAP1 | HMG20A | 0.780774 | 3 | 0 | 3 |
| STEAP1 | ANKRD50 | 0.76338 | 3 | 0 | 3 |
| STEAP1 | MCTP1 | 0.761612 | 3 | 0 | 3 |
| STEAP1 | INTS10 | 0.75449 | 3 | 0 | 3 |
| STEAP1 | ST6GAL1 | 0.719823 | 3 | 0 | 3 |
| STEAP1 | UHMK1 | 0.715847 | 3 | 0 | 3 |
| STEAP1 | SERTAD4 | 0.714914 | 3 | 0 | 3 |
| STEAP1 | MTHFD1L | 0.714217 | 3 | 0 | 3 |
| STEAP1 | SDR39U1 | 0.708927 | 3 | 0 | 3 |
| STEAP1 | ERP29 | 0.70427 | 3 | 0 | 3 |
| STEAP1 | SLC25A19 | 0.700315 | 3 | 0 | 3 |
| STEAP1 | CLDN1 | 0.687218 | 5 | 0 | 4 |
| STEAP1 | NRARP | 0.686361 | 3 | 0 | 3 |
| STEAP1 | RNMT | 0.682897 | 3 | 0 | 3 |
| STEAP1 | TBX20 | 0.678775 | 3 | 0 | 3 |
| STEAP1 | SLC35E3 | 0.678762 | 3 | 0 | 3 |
| STEAP1 | CALCRL | 0.677785 | 4 | 0 | 3 |
| STEAP1 | RPF1 | 0.677372 | 3 | 0 | 3 |
| STEAP1 | FRMD6 | 0.675543 | 3 | 0 | 3 |
For details and further investigation, click here
