| Full name: claudin 1 | Alias Symbol: SEMP1|ILVASC | ||
| Type: protein-coding gene | Cytoband: 3q28 | ||
| Entrez ID: 9076 | HGNC ID: HGNC:2032 | Ensembl Gene: ENSG00000163347 | OMIM ID: 603718 |
| Drug and gene relationship at DGIdb | |||
CLDN1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN1 | 9076 | 222549_at | 0.1735 | 0.9295 | |
| GSE20347 | CLDN1 | 9076 | 218182_s_at | 0.8217 | 0.0130 | |
| GSE23400 | CLDN1 | 9076 | 218182_s_at | 0.8737 | 0.0000 | |
| GSE26886 | CLDN1 | 9076 | 222549_at | 0.6698 | 0.2964 | |
| GSE29001 | CLDN1 | 9076 | 218182_s_at | 0.7737 | 0.0359 | |
| GSE38129 | CLDN1 | 9076 | 218182_s_at | 1.4696 | 0.0001 | |
| GSE45670 | CLDN1 | 9076 | 222549_at | 0.8596 | 0.0291 | |
| GSE53622 | CLDN1 | 9076 | 108089 | 1.1828 | 0.0000 | |
| GSE53624 | CLDN1 | 9076 | 108089 | 0.6063 | 0.0002 | |
| GSE63941 | CLDN1 | 9076 | 222549_at | 3.6647 | 0.0763 | |
| GSE77861 | CLDN1 | 9076 | 222549_at | 0.8944 | 0.0735 | |
| GSE97050 | CLDN1 | 9076 | A_23_P57784 | 1.5519 | 0.2444 | |
| SRP007169 | CLDN1 | 9076 | RNAseq | 0.1558 | 0.7855 | |
| SRP008496 | CLDN1 | 9076 | RNAseq | 0.2713 | 0.4477 | |
| SRP064894 | CLDN1 | 9076 | RNAseq | 1.2535 | 0.0062 | |
| SRP133303 | CLDN1 | 9076 | RNAseq | 1.3753 | 0.0005 | |
| SRP159526 | CLDN1 | 9076 | RNAseq | 1.2401 | 0.0311 | |
| SRP219564 | CLDN1 | 9076 | RNAseq | 1.6600 | 0.0838 | |
| TCGA | CLDN1 | 9076 | RNAseq | 1.2012 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by CLDN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN1 | 9076 | 25 | 0 | 5 | |
| GSE20123 | CLDN1 | 9076 | 25 | 0 | 5 | |
| GSE43470 | CLDN1 | 9076 | 23 | 0 | 20 | |
| GSE46452 | CLDN1 | 9076 | 19 | 1 | 39 | |
| GSE47630 | CLDN1 | 9076 | 27 | 2 | 11 | |
| GSE54993 | CLDN1 | 9076 | 1 | 19 | 50 | |
| GSE54994 | CLDN1 | 9076 | 39 | 0 | 14 | |
| GSE60625 | CLDN1 | 9076 | 0 | 6 | 5 | |
| GSE74703 | CLDN1 | 9076 | 20 | 0 | 16 | |
| GSE74704 | CLDN1 | 9076 | 17 | 0 | 3 | |
| TCGA | CLDN1 | 9076 | 76 | 0 | 20 |
Total number of gains: 272; Total number of losses: 28; Total Number of normals: 188.
Somatic mutations of CLDN1:
Generating mutation plots.
Highly correlated genes for CLDN1:
Showing top 20/402 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN1 | NCEH1 | 0.72152 | 3 | 0 | 3 |
| CLDN1 | ETNK1 | 0.71034 | 3 | 0 | 3 |
| CLDN1 | GMCL1 | 0.705368 | 3 | 0 | 3 |
| CLDN1 | CCDC117 | 0.694861 | 3 | 0 | 3 |
| CLDN1 | TAS2R19 | 0.693304 | 3 | 0 | 3 |
| CLDN1 | RNF19B | 0.690783 | 4 | 0 | 3 |
| CLDN1 | STEAP1 | 0.687218 | 5 | 0 | 4 |
| CLDN1 | SLC44A1 | 0.681034 | 4 | 0 | 3 |
| CLDN1 | FBXO11 | 0.659675 | 3 | 0 | 3 |
| CLDN1 | TMEM51 | 0.656644 | 3 | 0 | 3 |
| CLDN1 | SLC22A23 | 0.656594 | 3 | 0 | 3 |
| CLDN1 | STK4 | 0.654737 | 3 | 0 | 3 |
| CLDN1 | SPAST | 0.650112 | 4 | 0 | 3 |
| CLDN1 | RTN4IP1 | 0.64983 | 4 | 0 | 3 |
| CLDN1 | CTSH | 0.645954 | 4 | 0 | 3 |
| CLDN1 | CD14 | 0.64578 | 3 | 0 | 3 |
| CLDN1 | ANKRD50 | 0.640065 | 3 | 0 | 3 |
| CLDN1 | POLB | 0.638696 | 3 | 0 | 3 |
| CLDN1 | AEBP2 | 0.637438 | 3 | 0 | 3 |
| CLDN1 | FAM220A | 0.633578 | 5 | 0 | 4 |
For details and further investigation, click here
