| Full name: elongation factor for RNA polymerase II | Alias Symbol: Men|ELL1|PPP1R68 | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 8178 | HGNC ID: HGNC:23114 | Ensembl Gene: ENSG00000105656 | OMIM ID: 600284 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ELL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ELL | 8178 | 204096_s_at | 0.0002 | 0.9994 | |
| GSE20347 | ELL | 8178 | 204095_s_at | -0.1875 | 0.0291 | |
| GSE23400 | ELL | 8178 | 204096_s_at | -0.0982 | 0.0123 | |
| GSE26886 | ELL | 8178 | 204096_s_at | 0.1042 | 0.5469 | |
| GSE29001 | ELL | 8178 | 204096_s_at | 0.0780 | 0.6546 | |
| GSE38129 | ELL | 8178 | 204096_s_at | -0.0342 | 0.6366 | |
| GSE45670 | ELL | 8178 | 204096_s_at | -0.0724 | 0.5611 | |
| GSE53622 | ELL | 8178 | 76103 | 0.3487 | 0.0000 | |
| GSE53624 | ELL | 8178 | 76103 | 0.2856 | 0.0000 | |
| GSE63941 | ELL | 8178 | 204096_s_at | -0.5683 | 0.0215 | |
| GSE77861 | ELL | 8178 | 204095_s_at | -0.1772 | 0.1941 | |
| GSE97050 | ELL | 8178 | A_33_P3406505 | 0.3702 | 0.1980 | |
| SRP007169 | ELL | 8178 | RNAseq | 0.0305 | 0.9492 | |
| SRP064894 | ELL | 8178 | RNAseq | 0.1757 | 0.4158 | |
| SRP133303 | ELL | 8178 | RNAseq | 0.0828 | 0.5412 | |
| SRP159526 | ELL | 8178 | RNAseq | -0.3867 | 0.1325 | |
| SRP193095 | ELL | 8178 | RNAseq | 0.3391 | 0.0193 | |
| SRP219564 | ELL | 8178 | RNAseq | 0.1647 | 0.5943 | |
| TCGA | ELL | 8178 | RNAseq | -0.0251 | 0.6294 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ELL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ELL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ELL | 8178 | 4 | 5 | 21 | |
| GSE20123 | ELL | 8178 | 3 | 3 | 24 | |
| GSE43470 | ELL | 8178 | 2 | 5 | 36 | |
| GSE46452 | ELL | 8178 | 47 | 1 | 11 | |
| GSE47630 | ELL | 8178 | 4 | 8 | 28 | |
| GSE54993 | ELL | 8178 | 15 | 4 | 51 | |
| GSE54994 | ELL | 8178 | 6 | 13 | 34 | |
| GSE60625 | ELL | 8178 | 9 | 0 | 2 | |
| GSE74703 | ELL | 8178 | 2 | 3 | 31 | |
| GSE74704 | ELL | 8178 | 0 | 3 | 17 | |
| TCGA | ELL | 8178 | 16 | 10 | 70 |
Total number of gains: 108; Total number of losses: 55; Total Number of normals: 325.
Somatic mutations of ELL:
Generating mutation plots.
Highly correlated genes for ELL:
Showing top 20/49 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ELL | SUFU | 0.718994 | 3 | 0 | 3 |
| ELL | CRIP3 | 0.676627 | 3 | 0 | 3 |
| ELL | TAF10 | 0.641903 | 3 | 0 | 3 |
| ELL | CCL7 | 0.640766 | 3 | 0 | 3 |
| ELL | EVA1B | 0.638186 | 3 | 0 | 3 |
| ELL | LINC00475 | 0.634312 | 3 | 0 | 3 |
| ELL | NUDT16L1 | 0.629124 | 3 | 0 | 3 |
| ELL | CTSD | 0.606813 | 4 | 0 | 3 |
| ELL | MSC | 0.597329 | 4 | 0 | 3 |
| ELL | ATP6V0C | 0.596435 | 5 | 0 | 3 |
| ELL | GLI4 | 0.595745 | 3 | 0 | 3 |
| ELL | CORO1B | 0.594877 | 4 | 0 | 3 |
| ELL | CLEC12B | 0.593722 | 3 | 0 | 3 |
| ELL | FBRS | 0.593666 | 4 | 0 | 3 |
| ELL | CXCR3 | 0.588362 | 5 | 0 | 4 |
| ELL | ADAM12 | 0.578079 | 4 | 0 | 3 |
| ELL | ARSA | 0.562042 | 5 | 0 | 3 |
| ELL | ARHGAP17 | 0.560685 | 5 | 0 | 3 |
| ELL | COMP | 0.55896 | 4 | 0 | 3 |
| ELL | TSC22D4 | 0.556873 | 5 | 0 | 3 |
For details and further investigation, click here
