| Full name: DNA methyltransferase 3 alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 1788 | HGNC ID: HGNC:2978 | Ensembl Gene: ENSG00000119772 | OMIM ID: 602769 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DNMT3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNMT3A | 1788 | 222640_at | 0.5785 | 0.0583 | |
| GSE20347 | DNMT3A | 1788 | 218457_s_at | 0.0013 | 0.9913 | |
| GSE23400 | DNMT3A | 1788 | 218457_s_at | -0.0215 | 0.5271 | |
| GSE26886 | DNMT3A | 1788 | 222640_at | 1.0832 | 0.0085 | |
| GSE29001 | DNMT3A | 1788 | 218457_s_at | 0.2820 | 0.5080 | |
| GSE38129 | DNMT3A | 1788 | 218457_s_at | 0.1203 | 0.6543 | |
| GSE45670 | DNMT3A | 1788 | 222640_at | 0.4247 | 0.0156 | |
| GSE53622 | DNMT3A | 1788 | 56353 | 0.6714 | 0.0000 | |
| GSE53624 | DNMT3A | 1788 | 56353 | 0.6797 | 0.0000 | |
| GSE63941 | DNMT3A | 1788 | 222640_at | -0.7370 | 0.3069 | |
| GSE77861 | DNMT3A | 1788 | 222640_at | 0.3139 | 0.0820 | |
| GSE97050 | DNMT3A | 1788 | A_33_P3272330 | 0.1933 | 0.4581 | |
| SRP007169 | DNMT3A | 1788 | RNAseq | 1.6010 | 0.0002 | |
| SRP008496 | DNMT3A | 1788 | RNAseq | 1.3605 | 0.0000 | |
| SRP064894 | DNMT3A | 1788 | RNAseq | 0.4411 | 0.0025 | |
| SRP133303 | DNMT3A | 1788 | RNAseq | 0.0234 | 0.8270 | |
| SRP193095 | DNMT3A | 1788 | RNAseq | 0.6392 | 0.0000 | |
| SRP219564 | DNMT3A | 1788 | RNAseq | 0.3288 | 0.3677 | |
| TCGA | DNMT3A | 1788 | RNAseq | 0.0260 | 0.7391 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DNMT3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNMT3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNMT3A | 1788 | 11 | 2 | 17 | |
| GSE20123 | DNMT3A | 1788 | 11 | 2 | 17 | |
| GSE43470 | DNMT3A | 1788 | 3 | 1 | 39 | |
| GSE46452 | DNMT3A | 1788 | 3 | 4 | 52 | |
| GSE47630 | DNMT3A | 1788 | 8 | 0 | 32 | |
| GSE54993 | DNMT3A | 1788 | 0 | 6 | 64 | |
| GSE54994 | DNMT3A | 1788 | 10 | 0 | 43 | |
| GSE60625 | DNMT3A | 1788 | 0 | 3 | 8 | |
| GSE74703 | DNMT3A | 1788 | 3 | 0 | 33 | |
| GSE74704 | DNMT3A | 1788 | 9 | 1 | 10 | |
| TCGA | DNMT3A | 1788 | 37 | 2 | 57 |
Total number of gains: 95; Total number of losses: 21; Total Number of normals: 372.
Somatic mutations of DNMT3A:
Generating mutation plots.
Highly correlated genes for DNMT3A:
Showing top 20/952 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNMT3A | SYMPK | 0.746402 | 4 | 0 | 4 |
| DNMT3A | ADRM1 | 0.743869 | 3 | 0 | 3 |
| DNMT3A | GTPBP1 | 0.741721 | 3 | 0 | 3 |
| DNMT3A | PDE7A | 0.724703 | 5 | 0 | 5 |
| DNMT3A | TRAF3IP1 | 0.705622 | 4 | 0 | 4 |
| DNMT3A | MAGEH1 | 0.701259 | 4 | 0 | 4 |
| DNMT3A | CBFA2T2 | 0.698857 | 3 | 0 | 3 |
| DNMT3A | IPO9 | 0.698783 | 4 | 0 | 4 |
| DNMT3A | RICTOR | 0.696846 | 3 | 0 | 3 |
| DNMT3A | CCDC14 | 0.696392 | 6 | 0 | 6 |
| DNMT3A | U2SURP | 0.694114 | 6 | 0 | 6 |
| DNMT3A | PIEZO1 | 0.693089 | 4 | 0 | 3 |
| DNMT3A | CENPBD1 | 0.692691 | 3 | 0 | 3 |
| DNMT3A | UHMK1 | 0.690179 | 3 | 0 | 3 |
| DNMT3A | SGCB | 0.689701 | 3 | 0 | 3 |
| DNMT3A | KCNJ8 | 0.687977 | 3 | 0 | 3 |
| DNMT3A | RRS1 | 0.687575 | 4 | 0 | 3 |
| DNMT3A | DERL1 | 0.68649 | 3 | 0 | 3 |
| DNMT3A | BFSP1 | 0.684223 | 3 | 0 | 3 |
| DNMT3A | GEMIN5 | 0.682897 | 4 | 0 | 3 |
For details and further investigation, click here
