| Full name: SYS1 golgi trafficking protein | Alias Symbol: dJ453C12.4 | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 90196 | HGNC ID: HGNC:16162 | Ensembl Gene: ENSG00000204070 | OMIM ID: 612979 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SYS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SYS1 | 90196 | 224670_at | 0.1484 | 0.7711 | |
| GSE26886 | SYS1 | 90196 | 224668_at | -0.2449 | 0.2332 | |
| GSE45670 | SYS1 | 90196 | 224668_at | 0.1242 | 0.2329 | |
| GSE53622 | SYS1 | 90196 | 132401 | 0.1286 | 0.0147 | |
| GSE53624 | SYS1 | 90196 | 132401 | -0.0373 | 0.6495 | |
| GSE63941 | SYS1 | 90196 | 224670_at | 0.5173 | 0.2003 | |
| GSE77861 | SYS1 | 90196 | 224670_at | -0.0436 | 0.7599 | |
| GSE97050 | SYS1 | 90196 | A_33_P3398107 | 0.2366 | 0.4323 | |
| SRP007169 | SYS1 | 90196 | RNAseq | -0.0665 | 0.8672 | |
| SRP008496 | SYS1 | 90196 | RNAseq | -0.1331 | 0.6252 | |
| SRP064894 | SYS1 | 90196 | RNAseq | 0.0812 | 0.7097 | |
| SRP133303 | SYS1 | 90196 | RNAseq | 0.0259 | 0.8387 | |
| SRP159526 | SYS1 | 90196 | RNAseq | 0.0072 | 0.9761 | |
| SRP193095 | SYS1 | 90196 | RNAseq | -0.0325 | 0.7373 | |
| SRP219564 | SYS1 | 90196 | RNAseq | -0.0192 | 0.9452 | |
| TCGA | SYS1 | 90196 | RNAseq | -0.1203 | 0.0224 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SYS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SYS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SYS1 | 90196 | 14 | 1 | 15 | |
| GSE20123 | SYS1 | 90196 | 14 | 1 | 15 | |
| GSE43470 | SYS1 | 90196 | 12 | 1 | 30 | |
| GSE46452 | SYS1 | 90196 | 29 | 0 | 30 | |
| GSE47630 | SYS1 | 90196 | 24 | 1 | 15 | |
| GSE54993 | SYS1 | 90196 | 0 | 17 | 53 | |
| GSE54994 | SYS1 | 90196 | 25 | 0 | 28 | |
| GSE60625 | SYS1 | 90196 | 0 | 0 | 11 | |
| GSE74703 | SYS1 | 90196 | 10 | 1 | 25 | |
| GSE74704 | SYS1 | 90196 | 10 | 0 | 10 | |
| TCGA | SYS1 | 90196 | 45 | 3 | 48 |
Total number of gains: 183; Total number of losses: 25; Total Number of normals: 280.
Somatic mutations of SYS1:
Generating mutation plots.
Highly correlated genes for SYS1:
Showing top 20/178 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SYS1 | NBAS | 0.712501 | 3 | 0 | 3 |
| SYS1 | PSAP | 0.709678 | 3 | 0 | 3 |
| SYS1 | GPX1 | 0.699702 | 3 | 0 | 3 |
| SYS1 | TRIM37 | 0.696151 | 3 | 0 | 3 |
| SYS1 | SNX20 | 0.692891 | 3 | 0 | 3 |
| SYS1 | STUB1 | 0.683464 | 3 | 0 | 3 |
| SYS1 | HM13 | 0.681297 | 4 | 0 | 4 |
| SYS1 | FAM131B | 0.675214 | 3 | 0 | 3 |
| SYS1 | TXNDC11 | 0.675034 | 4 | 0 | 3 |
| SYS1 | NFKB1 | 0.66745 | 3 | 0 | 3 |
| SYS1 | DYNLRB1 | 0.661359 | 5 | 0 | 4 |
| SYS1 | TUBGCP2 | 0.660711 | 3 | 0 | 3 |
| SYS1 | SIK2 | 0.660628 | 3 | 0 | 3 |
| SYS1 | HLA-DPA1 | 0.660519 | 3 | 0 | 3 |
| SYS1 | ALOX5AP | 0.656611 | 3 | 0 | 3 |
| SYS1 | BBS4 | 0.649888 | 4 | 0 | 3 |
| SYS1 | UBE2C | 0.64948 | 3 | 0 | 3 |
| SYS1 | ZNF213 | 0.649114 | 4 | 0 | 3 |
| SYS1 | FTO | 0.64787 | 4 | 0 | 3 |
| SYS1 | PRR13 | 0.647754 | 3 | 0 | 3 |
For details and further investigation, click here
