| Full name: TAR DNA binding protein | Alias Symbol: TDP-43|ALS10 | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 23435 | HGNC ID: HGNC:11571 | Ensembl Gene: ENSG00000120948 | OMIM ID: 605078 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TARDBP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TARDBP | 23435 | 200020_at | 0.3324 | 0.3000 | |
| GSE20347 | TARDBP | 23435 | 200020_at | 0.3475 | 0.0018 | |
| GSE23400 | TARDBP | 23435 | 200020_at | 0.4271 | 0.0000 | |
| GSE26886 | TARDBP | 23435 | 200020_at | -0.3481 | 0.0160 | |
| GSE29001 | TARDBP | 23435 | 200020_at | 0.3280 | 0.0646 | |
| GSE38129 | TARDBP | 23435 | 200020_at | 0.4277 | 0.0000 | |
| GSE45670 | TARDBP | 23435 | 200020_at | 0.3634 | 0.0001 | |
| GSE53622 | TARDBP | 23435 | 142401 | 0.1711 | 0.0000 | |
| GSE53624 | TARDBP | 23435 | 142401 | 0.4052 | 0.0000 | |
| GSE63941 | TARDBP | 23435 | 200020_at | -0.1631 | 0.4984 | |
| GSE77861 | TARDBP | 23435 | 200020_at | 0.3099 | 0.0545 | |
| GSE97050 | TARDBP | A_21_P0011146 | -0.0172 | 0.9558 | ||
| SRP007169 | TARDBP | 23435 | RNAseq | 0.0061 | 0.9824 | |
| SRP008496 | TARDBP | 23435 | RNAseq | 0.1108 | 0.4009 | |
| SRP064894 | TARDBP | 23435 | RNAseq | 0.1429 | 0.1904 | |
| SRP133303 | TARDBP | 23435 | RNAseq | 0.1461 | 0.1569 | |
| SRP159526 | TARDBP | 23435 | RNAseq | 0.2099 | 0.2866 | |
| SRP193095 | TARDBP | 23435 | RNAseq | -0.0638 | 0.5400 | |
| SRP219564 | TARDBP | 23435 | RNAseq | 0.0781 | 0.7022 | |
| TCGA | TARDBP | 23435 | RNAseq | 0.0827 | 0.0476 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TARDBP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TARDBP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TARDBP | 23435 | 0 | 5 | 25 | |
| GSE20123 | TARDBP | 23435 | 0 | 3 | 27 | |
| GSE43470 | TARDBP | 23435 | 6 | 5 | 32 | |
| GSE46452 | TARDBP | 23435 | 7 | 1 | 51 | |
| GSE47630 | TARDBP | 23435 | 8 | 4 | 28 | |
| GSE54993 | TARDBP | 23435 | 3 | 1 | 66 | |
| GSE54994 | TARDBP | 23435 | 11 | 4 | 38 | |
| GSE60625 | TARDBP | 23435 | 0 | 0 | 11 | |
| GSE74703 | TARDBP | 23435 | 5 | 3 | 28 | |
| GSE74704 | TARDBP | 23435 | 0 | 0 | 20 | |
| TCGA | TARDBP | 23435 | 10 | 22 | 64 |
Total number of gains: 50; Total number of losses: 48; Total Number of normals: 390.
Somatic mutations of TARDBP:
Generating mutation plots.
Highly correlated genes for TARDBP:
Showing top 20/1130 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TARDBP | SPNS1 | 0.781178 | 3 | 0 | 3 |
| TARDBP | MRTO4 | 0.775532 | 6 | 0 | 6 |
| TARDBP | TMED8 | 0.770326 | 3 | 0 | 3 |
| TARDBP | MRPS6 | 0.749562 | 4 | 0 | 4 |
| TARDBP | SURF6 | 0.745594 | 4 | 0 | 4 |
| TARDBP | GNPNAT1 | 0.734477 | 3 | 0 | 3 |
| TARDBP | PLEKHA8 | 0.724407 | 3 | 0 | 3 |
| TARDBP | ALG1 | 0.723966 | 3 | 0 | 3 |
| TARDBP | C1orf112 | 0.722704 | 8 | 0 | 7 |
| TARDBP | KBTBD6 | 0.720874 | 5 | 0 | 4 |
| TARDBP | JKAMP | 0.717826 | 4 | 0 | 4 |
| TARDBP | ZSCAN29 | 0.717792 | 3 | 0 | 3 |
| TARDBP | ISY1 | 0.715147 | 3 | 0 | 3 |
| TARDBP | KLHDC3 | 0.713597 | 3 | 0 | 3 |
| TARDBP | NSD1 | 0.712968 | 3 | 0 | 3 |
| TARDBP | ZNF280C | 0.710725 | 3 | 0 | 3 |
| TARDBP | KCTD15 | 0.710489 | 3 | 0 | 3 |
| TARDBP | LIN9 | 0.706662 | 3 | 0 | 3 |
| TARDBP | ZNF284 | 0.705968 | 3 | 0 | 3 |
| TARDBP | FUS | 0.702575 | 9 | 0 | 9 |
For details and further investigation, click here
