| Full name: tec protein tyrosine kinase | Alias Symbol: PSCTK4 | ||
| Type: protein-coding gene | Cytoband: 4p12-p11 | ||
| Entrez ID: 7006 | HGNC ID: HGNC:11719 | Ensembl Gene: ENSG00000135605 | OMIM ID: 600583 |
| Drug and gene relationship at DGIdb | |||
TEC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation | |
| hsa04660 | T cell receptor signaling pathway |
Expression of TEC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TEC | 7006 | 206301_at | -0.2880 | 0.3954 | |
| GSE20347 | TEC | 7006 | 206301_at | -0.2210 | 0.0266 | |
| GSE23400 | TEC | 7006 | 206301_at | -0.1656 | 0.0001 | |
| GSE26886 | TEC | 7006 | 206301_at | -0.7579 | 0.0000 | |
| GSE29001 | TEC | 7006 | 206301_at | -0.4348 | 0.0060 | |
| GSE38129 | TEC | 7006 | 206301_at | -0.2836 | 0.0003 | |
| GSE45670 | TEC | 7006 | 206301_at | -0.1177 | 0.2080 | |
| GSE53622 | TEC | 7006 | 62851 | -1.6976 | 0.0000 | |
| GSE53624 | TEC | 7006 | 62851 | -2.0989 | 0.0000 | |
| GSE63941 | TEC | 7006 | 206301_at | 0.2375 | 0.2054 | |
| GSE77861 | TEC | 7006 | 206301_at | -0.1193 | 0.3045 | |
| GSE97050 | TEC | 7006 | A_24_P37712 | 0.0251 | 0.9541 | |
| SRP007169 | TEC | 7006 | RNAseq | -2.4755 | 0.0001 | |
| SRP133303 | TEC | 7006 | RNAseq | -1.4711 | 0.0000 | |
| SRP159526 | TEC | 7006 | RNAseq | -2.5758 | 0.0005 | |
| SRP193095 | TEC | 7006 | RNAseq | -2.0865 | 0.0000 | |
| SRP219564 | TEC | 7006 | RNAseq | -2.5747 | 0.0001 | |
| TCGA | TEC | 7006 | RNAseq | -0.2803 | 0.1667 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by TEC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TEC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TEC | 7006 | 1 | 15 | 14 | |
| GSE20123 | TEC | 7006 | 1 | 15 | 14 | |
| GSE43470 | TEC | 7006 | 0 | 13 | 30 | |
| GSE46452 | TEC | 7006 | 1 | 37 | 21 | |
| GSE47630 | TEC | 7006 | 1 | 18 | 21 | |
| GSE54993 | TEC | 7006 | 7 | 0 | 63 | |
| GSE54994 | TEC | 7006 | 4 | 9 | 40 | |
| GSE60625 | TEC | 7006 | 0 | 0 | 11 | |
| GSE74703 | TEC | 7006 | 0 | 11 | 25 | |
| GSE74704 | TEC | 7006 | 0 | 9 | 11 | |
| TCGA | TEC | 7006 | 21 | 34 | 41 |
Total number of gains: 36; Total number of losses: 161; Total Number of normals: 291.
Somatic mutations of TEC:
Generating mutation plots.
Highly correlated genes for TEC:
Showing top 20/1079 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TEC | CA13 | 0.751192 | 3 | 0 | 3 |
| TEC | EPGN | 0.74782 | 3 | 0 | 3 |
| TEC | LTA4H | 0.72588 | 3 | 0 | 3 |
| TEC | ZNF431 | 0.723804 | 3 | 0 | 3 |
| TEC | CEACAM3 | 0.722391 | 6 | 0 | 6 |
| TEC | GRPEL2 | 0.692506 | 4 | 0 | 4 |
| TEC | CXCL17 | 0.690847 | 5 | 0 | 5 |
| TEC | CASC3 | 0.690639 | 3 | 0 | 3 |
| TEC | SLC10A5 | 0.690633 | 4 | 0 | 3 |
| TEC | PDCL2 | 0.686003 | 3 | 0 | 3 |
| TEC | CHMP4B | 0.68592 | 3 | 0 | 3 |
| TEC | IL34 | 0.683723 | 4 | 0 | 3 |
| TEC | UPK3B | 0.682257 | 3 | 0 | 3 |
| TEC | FAM214A | 0.674641 | 5 | 0 | 4 |
| TEC | STH | 0.670867 | 3 | 0 | 3 |
| TEC | VPS25 | 0.669348 | 6 | 0 | 6 |
| TEC | ARSF | 0.662626 | 8 | 0 | 7 |
| TEC | YOD1 | 0.662581 | 7 | 0 | 5 |
| TEC | WNK4 | 0.659779 | 4 | 0 | 3 |
| TEC | CBR3-AS1 | 0.659753 | 6 | 0 | 4 |
For details and further investigation, click here
