| Full name: charged multivesicular body protein 4B | Alias Symbol: dJ553F4.4|Shax1|SNF7-2|VPS32B | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 128866 | HGNC ID: HGNC:16171 | Ensembl Gene: ENSG00000101421 | OMIM ID: 610897 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CHMP4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHMP4B | 128866 | 225498_at | -0.3952 | 0.3758 | |
| GSE26886 | CHMP4B | 128866 | 225498_at | -0.2587 | 0.4214 | |
| GSE45670 | CHMP4B | 128866 | 225498_at | -0.5111 | 0.0046 | |
| GSE53622 | CHMP4B | 128866 | 53945 | -0.5225 | 0.0000 | |
| GSE53624 | CHMP4B | 128866 | 53945 | -0.5652 | 0.0000 | |
| GSE63941 | CHMP4B | 128866 | 225498_at | -0.4826 | 0.3642 | |
| GSE77861 | CHMP4B | 128866 | 225498_at | -0.2364 | 0.5519 | |
| GSE97050 | CHMP4B | 128866 | A_23_P28969 | -0.0657 | 0.8581 | |
| SRP007169 | CHMP4B | 128866 | RNAseq | -1.1371 | 0.0033 | |
| SRP008496 | CHMP4B | 128866 | RNAseq | -0.7491 | 0.0059 | |
| SRP064894 | CHMP4B | 128866 | RNAseq | -0.1212 | 0.5244 | |
| SRP133303 | CHMP4B | 128866 | RNAseq | -0.2136 | 0.0429 | |
| SRP159526 | CHMP4B | 128866 | RNAseq | -0.7608 | 0.0000 | |
| SRP193095 | CHMP4B | 128866 | RNAseq | -0.7059 | 0.0000 | |
| SRP219564 | CHMP4B | 128866 | RNAseq | -0.1611 | 0.3440 | |
| TCGA | CHMP4B | 128866 | RNAseq | 0.0591 | 0.1967 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CHMP4B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHMP4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHMP4B | 128866 | 15 | 0 | 15 | |
| GSE20123 | CHMP4B | 128866 | 15 | 0 | 15 | |
| GSE43470 | CHMP4B | 128866 | 12 | 0 | 31 | |
| GSE46452 | CHMP4B | 128866 | 29 | 0 | 30 | |
| GSE47630 | CHMP4B | 128866 | 24 | 1 | 15 | |
| GSE54993 | CHMP4B | 128866 | 0 | 19 | 51 | |
| GSE54994 | CHMP4B | 128866 | 25 | 2 | 26 | |
| GSE60625 | CHMP4B | 128866 | 0 | 0 | 11 | |
| GSE74703 | CHMP4B | 128866 | 11 | 0 | 25 | |
| GSE74704 | CHMP4B | 128866 | 10 | 0 | 10 | |
| TCGA | CHMP4B | 128866 | 51 | 1 | 44 |
Total number of gains: 192; Total number of losses: 23; Total Number of normals: 273.
Somatic mutations of CHMP4B:
Generating mutation plots.
Highly correlated genes for CHMP4B:
Showing top 20/868 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHMP4B | RASA1 | 0.804263 | 3 | 0 | 3 |
| CHMP4B | CCNY | 0.755005 | 3 | 0 | 3 |
| CHMP4B | ZNF626 | 0.749824 | 3 | 0 | 3 |
| CHMP4B | RPL41 | 0.743278 | 3 | 0 | 3 |
| CHMP4B | PSEN1 | 0.73451 | 3 | 0 | 3 |
| CHMP4B | STX6 | 0.726611 | 3 | 0 | 3 |
| CHMP4B | STOML2 | 0.72141 | 3 | 0 | 3 |
| CHMP4B | UQCRC2 | 0.71689 | 4 | 0 | 4 |
| CHMP4B | RAB1A | 0.712566 | 3 | 0 | 3 |
| CHMP4B | TMEM186 | 0.709224 | 3 | 0 | 3 |
| CHMP4B | AP1B1 | 0.706198 | 3 | 0 | 3 |
| CHMP4B | C2orf49 | 0.701393 | 3 | 0 | 3 |
| CHMP4B | SYTL2 | 0.70073 | 3 | 0 | 3 |
| CHMP4B | THAP8 | 0.696287 | 3 | 0 | 3 |
| CHMP4B | COPZ1 | 0.690139 | 3 | 0 | 3 |
| CHMP4B | DHRS7 | 0.688354 | 3 | 0 | 3 |
| CHMP4B | NDUFB6 | 0.685979 | 4 | 0 | 3 |
| CHMP4B | TEC | 0.68592 | 3 | 0 | 3 |
| CHMP4B | ZFP62 | 0.685807 | 3 | 0 | 3 |
| CHMP4B | C1orf50 | 0.685647 | 4 | 0 | 3 |
For details and further investigation, click here
