| Full name: claudin 5 | Alias Symbol: CPETRL1|BEC1 | ||
| Type: protein-coding gene | Cytoband: 22q11.21 | ||
| Entrez ID: 7122 | HGNC ID: HGNC:2047 | Ensembl Gene: ENSG00000184113 | OMIM ID: 602101 |
| Drug and gene relationship at DGIdb | |||
CLDN5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN5 | 7122 | 204482_at | -0.9792 | 0.0643 | |
| GSE20347 | CLDN5 | 7122 | 204482_at | -0.5270 | 0.0007 | |
| GSE23400 | CLDN5 | 7122 | 204482_at | -0.4963 | 0.0000 | |
| GSE26886 | CLDN5 | 7122 | 204482_at | 0.3920 | 0.2506 | |
| GSE29001 | CLDN5 | 7122 | 204482_at | -0.4360 | 0.3467 | |
| GSE38129 | CLDN5 | 7122 | 204482_at | -0.8266 | 0.0026 | |
| GSE45670 | CLDN5 | 7122 | 204482_at | -0.7836 | 0.0001 | |
| GSE53622 | CLDN5 | 7122 | 101846 | -1.1852 | 0.0000 | |
| GSE53624 | CLDN5 | 7122 | 101846 | -1.1957 | 0.0000 | |
| GSE63941 | CLDN5 | 7122 | 204482_at | 0.1948 | 0.3092 | |
| GSE77861 | CLDN5 | 7122 | 204482_at | 0.2522 | 0.2241 | |
| GSE97050 | CLDN5 | 7122 | A_33_P3285540 | 0.0207 | 0.9458 | |
| SRP007169 | CLDN5 | 7122 | RNAseq | -0.4534 | 0.4270 | |
| SRP064894 | CLDN5 | 7122 | RNAseq | -0.4688 | 0.3412 | |
| SRP133303 | CLDN5 | 7122 | RNAseq | -1.9287 | 0.0000 | |
| SRP159526 | CLDN5 | 7122 | RNAseq | -0.9507 | 0.0366 | |
| SRP193095 | CLDN5 | 7122 | RNAseq | -0.0197 | 0.9563 | |
| SRP219564 | CLDN5 | 7122 | RNAseq | -0.6651 | 0.1517 | |
| TCGA | CLDN5 | 7122 | RNAseq | -0.5952 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CLDN5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN5 | 7122 | 4 | 7 | 19 | |
| GSE20123 | CLDN5 | 7122 | 4 | 7 | 19 | |
| GSE43470 | CLDN5 | 7122 | 4 | 6 | 33 | |
| GSE46452 | CLDN5 | 7122 | 33 | 1 | 25 | |
| GSE47630 | CLDN5 | 7122 | 8 | 5 | 27 | |
| GSE54993 | CLDN5 | 7122 | 3 | 7 | 60 | |
| GSE54994 | CLDN5 | 7122 | 12 | 7 | 34 | |
| GSE60625 | CLDN5 | 7122 | 5 | 0 | 6 | |
| GSE74703 | CLDN5 | 7122 | 4 | 4 | 28 | |
| GSE74704 | CLDN5 | 7122 | 2 | 4 | 14 | |
| TCGA | CLDN5 | 7122 | 27 | 17 | 52 |
Total number of gains: 106; Total number of losses: 65; Total Number of normals: 317.
Somatic mutations of CLDN5:
Generating mutation plots.
Highly correlated genes for CLDN5:
Showing top 20/649 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN5 | COL14A1 | 0.780166 | 8 | 0 | 8 |
| CLDN5 | TEK | 0.756058 | 8 | 0 | 7 |
| CLDN5 | ACKR1 | 0.754033 | 9 | 0 | 8 |
| CLDN5 | FAM107A | 0.750863 | 8 | 0 | 8 |
| CLDN5 | CCL14 | 0.736435 | 3 | 0 | 3 |
| CLDN5 | ECSCR | 0.736123 | 6 | 0 | 6 |
| CLDN5 | CLEC3B | 0.734658 | 3 | 0 | 3 |
| CLDN5 | PREX2 | 0.726604 | 4 | 0 | 4 |
| CLDN5 | TNFRSF19 | 0.724258 | 3 | 0 | 3 |
| CLDN5 | GPIHBP1 | 0.722771 | 3 | 0 | 3 |
| CLDN5 | MAML2 | 0.716989 | 3 | 0 | 3 |
| CLDN5 | EBF1 | 0.716239 | 7 | 0 | 7 |
| CLDN5 | GIMAP7 | 0.715035 | 5 | 0 | 5 |
| CLDN5 | CYP21A2 | 0.713895 | 3 | 0 | 3 |
| CLDN5 | APOLD1 | 0.711964 | 8 | 0 | 8 |
| CLDN5 | NEGR1 | 0.710669 | 4 | 0 | 4 |
| CLDN5 | CLEC10A | 0.704055 | 7 | 0 | 7 |
| CLDN5 | CFD | 0.702147 | 9 | 0 | 9 |
| CLDN5 | ZEB2 | 0.69792 | 8 | 0 | 7 |
| CLDN5 | GIMAP8 | 0.694798 | 5 | 0 | 5 |
For details and further investigation, click here
