TGFBR2

 

Full name: transforming growth factor beta receptor 2 Alias Symbol: TBRII|TBR-ii
Type: protein-coding gene Cytoband: 3p24.1
Entrez ID: 7048 HGNC ID: HGNC:11773 Ensembl Gene: ENSG00000163513 OMIM ID: 190182
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 4/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TGFBR2 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04068FoxO signaling pathway
hsa04350TGF-beta signaling pathway
hsa04380Osteoclast differentiation
hsa04390Hippo signaling pathway
hsa04520Adherens junction
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05142Chagas disease (American trypanosomiasis)
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia

 

Expression of TGFBR2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TGFBR2 7048 208944_at -0.5879 0.4436
GSE20347 TGFBR2 7048 208944_at -0.0407 0.8932
GSE23400 TGFBR2 7048 208944_at 0.0564 0.7781
GSE26886 TGFBR2 7048 208944_at -0.1440 0.7957
GSE29001 TGFBR2 7048 208944_at 0.1690 0.8062
GSE38129 TGFBR2 7048 208944_at -0.5773 0.1513
GSE45670 TGFBR2 7048 208944_at -1.2445 0.0029
GSE53622 TGFBR2 7048 144293 -0.6010 0.0000
GSE53624 TGFBR2 7048 144293 -0.4536 0.0027
GSE63941 TGFBR2 7048 208944_at -2.9365 0.0086
GSE77861 TGFBR2 7048 208944_at 0.4048 0.3514
GSE97050 TGFBR2 7048 A_23_P211957 -0.0472 0.8309
SRP007169 TGFBR2 7048 RNAseq 0.9521 0.0815
SRP008496 TGFBR2 7048 RNAseq 1.4971 0.0000
SRP064894 TGFBR2 7048 RNAseq 0.2433 0.5002
SRP133303 TGFBR2 7048 RNAseq -0.3705 0.1293
SRP159526 TGFBR2 7048 RNAseq -0.4138 0.3562
SRP193095 TGFBR2 7048 RNAseq 0.0342 0.9086
SRP219564 TGFBR2 7048 RNAseq 0.2400 0.7280
TCGA TGFBR2 7048 RNAseq -0.5052 0.0000

Upregulated datasets: 1; Downregulated datasets: 2.  

 

Survival by TGFBR2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TGFBR2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TGFBR2 7048 0 18 12
GSE20123 TGFBR2 7048 0 18 12
GSE43470 TGFBR2 7048 0 20 23
GSE46452 TGFBR2 7048 2 17 40
GSE47630 TGFBR2 7048 1 24 15
GSE54993 TGFBR2 7048 6 3 61
GSE54994 TGFBR2 7048 1 32 20
GSE60625 TGFBR2 7048 5 0 6
GSE74703 TGFBR2 7048 0 17 19
GSE74704 TGFBR2 7048 0 12 8
TCGA TGFBR2 7048 1 69 26

Total number of gains: 16; Total number of losses: 230; Total Number of normals: 242.  

 

Somatic mutations of TGFBR2:

 

Generating mutation plots.

 

Highly correlated genes for TGFBR2:

 

Showing top 20/1130 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TGFBR2GIMAP50.780312303
TGFBR2SMPD10.767314303
TGFBR2ZNF5830.743779303
TGFBR2LYVE10.740703707
TGFBR2AP2B10.739851303
TGFBR2ZDHHC40.733248303
TGFBR2NEK30.730947403
TGFBR2MMRN20.728635707
TGFBR2FAM160B10.727486404
TGFBR2DNALI10.725768606
TGFBR2TEK0.725605
TGFBR2TCEAL60.721146303
TGFBR2GIMAP60.72068707
TGFBR2SGTB0.718467505
TGFBR2ZSWIM50.716953303
TGFBR2GLIPR20.715265505
TGFBR2EFEMP10.71362911010
TGFBR2ACVRL10.712908505
TGFBR2IRAK30.712495504
TGFBR2SPTBN10.711117706

For details and further investigation, click here