| Full name: THO complex 7 | Alias Symbol: NIF3L1BP1|FLJ23445|fSAP24 | ||
| Type: protein-coding gene | Cytoband: 3p14.1 | ||
| Entrez ID: 80145 | HGNC ID: HGNC:29874 | Ensembl Gene: ENSG00000163634 | OMIM ID: 611965 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of THOC7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THOC7 | 80145 | 218334_at | -0.4952 | 0.1557 | |
| GSE20347 | THOC7 | 80145 | 218334_at | -0.7563 | 0.0000 | |
| GSE23400 | THOC7 | 80145 | 218334_at | -0.4802 | 0.0000 | |
| GSE26886 | THOC7 | 80145 | 218334_at | 0.0844 | 0.7407 | |
| GSE29001 | THOC7 | 80145 | 218334_at | -0.6721 | 0.0867 | |
| GSE38129 | THOC7 | 80145 | 218334_at | -0.5819 | 0.0001 | |
| GSE45670 | THOC7 | 80145 | 218334_at | -0.2875 | 0.0513 | |
| GSE53622 | THOC7 | 80145 | 5650 | -0.6570 | 0.0000 | |
| GSE53624 | THOC7 | 80145 | 5650 | -0.5725 | 0.0000 | |
| GSE63941 | THOC7 | 80145 | 218334_at | -0.2112 | 0.6019 | |
| GSE77861 | THOC7 | 80145 | 218334_at | -0.8444 | 0.0091 | |
| GSE97050 | THOC7 | 80145 | A_32_P136402 | -0.3364 | 0.2336 | |
| SRP007169 | THOC7 | 80145 | RNAseq | -1.0458 | 0.0077 | |
| SRP008496 | THOC7 | 80145 | RNAseq | -0.8188 | 0.0002 | |
| SRP064894 | THOC7 | 80145 | RNAseq | -0.5845 | 0.0000 | |
| SRP133303 | THOC7 | 80145 | RNAseq | -0.2600 | 0.1105 | |
| SRP159526 | THOC7 | 80145 | RNAseq | -0.8329 | 0.0027 | |
| SRP193095 | THOC7 | 80145 | RNAseq | -1.0162 | 0.0000 | |
| SRP219564 | THOC7 | 80145 | RNAseq | -0.9867 | 0.0001 | |
| TCGA | THOC7 | 80145 | RNAseq | 0.0076 | 0.8868 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by THOC7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THOC7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THOC7 | 80145 | 0 | 18 | 12 | |
| GSE20123 | THOC7 | 80145 | 0 | 18 | 12 | |
| GSE43470 | THOC7 | 80145 | 0 | 19 | 24 | |
| GSE46452 | THOC7 | 80145 | 2 | 17 | 40 | |
| GSE47630 | THOC7 | 80145 | 1 | 24 | 15 | |
| GSE54993 | THOC7 | 80145 | 5 | 2 | 63 | |
| GSE54994 | THOC7 | 80145 | 1 | 33 | 19 | |
| GSE60625 | THOC7 | 80145 | 3 | 1 | 7 | |
| GSE74703 | THOC7 | 80145 | 0 | 15 | 21 | |
| GSE74704 | THOC7 | 80145 | 0 | 12 | 8 | |
| TCGA | THOC7 | 80145 | 0 | 77 | 19 |
Total number of gains: 12; Total number of losses: 236; Total Number of normals: 240.
Somatic mutations of THOC7:
Generating mutation plots.
Highly correlated genes for THOC7:
Showing top 20/1446 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THOC7 | BDP1 | 0.764367 | 3 | 0 | 3 |
| THOC7 | ACAA1 | 0.75817 | 7 | 0 | 7 |
| THOC7 | SUCLG2 | 0.750838 | 12 | 0 | 12 |
| THOC7 | MPP7 | 0.750249 | 6 | 0 | 6 |
| THOC7 | TMEM38A | 0.734337 | 3 | 0 | 3 |
| THOC7 | UFL1 | 0.732678 | 10 | 0 | 10 |
| THOC7 | EMC3 | 0.729901 | 9 | 0 | 9 |
| THOC7 | CCNYL1 | 0.728487 | 4 | 0 | 4 |
| THOC7 | SLC46A2 | 0.72316 | 6 | 0 | 6 |
| THOC7 | RNF11 | 0.720448 | 10 | 0 | 10 |
| THOC7 | FHL5 | 0.720333 | 3 | 0 | 3 |
| THOC7 | RSRC2 | 0.71895 | 3 | 0 | 3 |
| THOC7 | CPPED1 | 0.718224 | 10 | 0 | 10 |
| THOC7 | GTF3C6 | 0.716925 | 4 | 0 | 3 |
| THOC7 | RSPH3 | 0.715416 | 4 | 0 | 4 |
| THOC7 | C1orf50 | 0.712088 | 3 | 0 | 3 |
| THOC7 | AK3 | 0.710683 | 6 | 0 | 6 |
| THOC7 | PDHB | 0.710503 | 12 | 0 | 12 |
| THOC7 | UBA3 | 0.709893 | 12 | 0 | 11 |
| THOC7 | CHMP2B | 0.708601 | 11 | 0 | 10 |
For details and further investigation, click here
