| Full name: pyruvate dehydrogenase E1 beta subunit | Alias Symbol: PDHE1B | ||
| Type: protein-coding gene | Cytoband: 3p14.3 | ||
| Entrez ID: 5162 | HGNC ID: HGNC:8808 | Ensembl Gene: ENSG00000168291 | OMIM ID: 179060 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PDHB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway |
Expression of PDHB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDHB | 5162 | 211023_at | -0.5463 | 0.1601 | |
| GSE20347 | PDHB | 5162 | 211023_at | -0.8828 | 0.0000 | |
| GSE23400 | PDHB | 5162 | 211023_at | -0.4354 | 0.0000 | |
| GSE26886 | PDHB | 5162 | 211023_at | -0.3802 | 0.0104 | |
| GSE29001 | PDHB | 5162 | 211023_at | -0.5587 | 0.0123 | |
| GSE38129 | PDHB | 5162 | 211023_at | -0.8386 | 0.0000 | |
| GSE45670 | PDHB | 5162 | 211023_at | -0.5606 | 0.0001 | |
| GSE53622 | PDHB | 5162 | 46826 | -0.7404 | 0.0000 | |
| GSE53624 | PDHB | 5162 | 46826 | -0.5656 | 0.0000 | |
| GSE63941 | PDHB | 5162 | 211023_at | -0.8977 | 0.0191 | |
| GSE77861 | PDHB | 5162 | 211023_at | -0.7598 | 0.0036 | |
| GSE97050 | PDHB | 5162 | A_33_P3364884 | -0.2892 | 0.3038 | |
| SRP007169 | PDHB | 5162 | RNAseq | -0.9093 | 0.0094 | |
| SRP008496 | PDHB | 5162 | RNAseq | -0.8119 | 0.0008 | |
| SRP064894 | PDHB | 5162 | RNAseq | -0.4707 | 0.0000 | |
| SRP133303 | PDHB | 5162 | RNAseq | -0.5508 | 0.0036 | |
| SRP159526 | PDHB | 5162 | RNAseq | -0.6121 | 0.0414 | |
| SRP193095 | PDHB | 5162 | RNAseq | -0.9827 | 0.0000 | |
| SRP219564 | PDHB | 5162 | RNAseq | -1.0699 | 0.0135 | |
| TCGA | PDHB | 5162 | RNAseq | -0.2924 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PDHB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDHB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDHB | 5162 | 0 | 17 | 13 | |
| GSE20123 | PDHB | 5162 | 0 | 18 | 12 | |
| GSE43470 | PDHB | 5162 | 0 | 17 | 26 | |
| GSE46452 | PDHB | 5162 | 2 | 17 | 40 | |
| GSE47630 | PDHB | 5162 | 1 | 24 | 15 | |
| GSE54993 | PDHB | 5162 | 6 | 2 | 62 | |
| GSE54994 | PDHB | 5162 | 0 | 32 | 21 | |
| GSE60625 | PDHB | 5162 | 5 | 0 | 6 | |
| GSE74703 | PDHB | 5162 | 0 | 14 | 22 | |
| GSE74704 | PDHB | 5162 | 0 | 11 | 9 | |
| TCGA | PDHB | 5162 | 0 | 79 | 17 |
Total number of gains: 14; Total number of losses: 231; Total Number of normals: 243.
Somatic mutations of PDHB:
Generating mutation plots.
Highly correlated genes for PDHB:
Showing top 20/1474 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDHB | CLEC3B | 0.769676 | 3 | 0 | 3 |
| PDHB | RGMB | 0.754225 | 3 | 0 | 3 |
| PDHB | SUCLG2 | 0.747394 | 13 | 0 | 13 |
| PDHB | ATF7 | 0.746399 | 4 | 0 | 3 |
| PDHB | CYP4V2 | 0.745952 | 3 | 0 | 3 |
| PDHB | SFTA2 | 0.743976 | 3 | 0 | 3 |
| PDHB | ZNF223 | 0.741398 | 3 | 0 | 3 |
| PDHB | KCTD6 | 0.733257 | 9 | 0 | 8 |
| PDHB | GTF3C6 | 0.729167 | 4 | 0 | 3 |
| PDHB | FBXO10 | 0.726592 | 4 | 0 | 3 |
| PDHB | ZNF436 | 0.725332 | 4 | 0 | 4 |
| PDHB | CMC1 | 0.724899 | 4 | 0 | 4 |
| PDHB | ANKRA2 | 0.715906 | 4 | 0 | 4 |
| PDHB | MRPS36 | 0.713346 | 7 | 0 | 6 |
| PDHB | LRRFIP2 | 0.713308 | 12 | 0 | 11 |
| PDHB | ZNF394 | 0.713254 | 3 | 0 | 3 |
| PDHB | THOC7 | 0.710503 | 12 | 0 | 12 |
| PDHB | RBM20 | 0.708324 | 4 | 0 | 3 |
| PDHB | HIGD1A | 0.706677 | 13 | 0 | 12 |
| PDHB | ZNF506 | 0.7053 | 3 | 0 | 3 |
For details and further investigation, click here
