THRAP3

 

Full name: thyroid hormone receptor associated protein 3 Alias Symbol: TRAP150|BCLAF2
Type: protein-coding gene Cytoband: 1p34.3
Entrez ID: 9967 HGNC ID: HGNC:22964 Ensembl Gene: ENSG00000054118 OMIM ID: 603809
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 22/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of THRAP3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 THRAP3 9967 222440_s_at 0.0126 0.9768
GSE20347 THRAP3 9967 217847_s_at -0.0325 0.7558
GSE23400 THRAP3 9967 217847_s_at 0.0350 0.5151
GSE26886 THRAP3 9967 222439_s_at -0.5579 0.0009
GSE29001 THRAP3 9967 217847_s_at -0.1613 0.3119
GSE38129 THRAP3 9967 217847_s_at 0.2527 0.0808
GSE45670 THRAP3 9967 222439_s_at -0.0416 0.8347
GSE53622 THRAP3 9967 74317 0.0549 0.3130
GSE53624 THRAP3 9967 75261 0.0577 0.7095
GSE63941 THRAP3 9967 222440_s_at -0.0403 0.8864
GSE77861 THRAP3 9967 222440_s_at -0.0613 0.6263
GSE97050 THRAP3 A_21_P0012374 -0.0600 0.8242
SRP007169 THRAP3 9967 RNAseq 0.9349 0.0621
SRP008496 THRAP3 9967 RNAseq 0.6123 0.0646
SRP064894 THRAP3 9967 RNAseq -0.0415 0.7567
SRP133303 THRAP3 9967 RNAseq -0.0277 0.7828
SRP159526 THRAP3 9967 RNAseq -0.1700 0.3206
SRP193095 THRAP3 9967 RNAseq -0.0102 0.8990
SRP219564 THRAP3 9967 RNAseq 0.0052 0.9769
TCGA THRAP3 9967 RNAseq -0.0343 0.3986

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by THRAP3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of THRAP3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 THRAP3 9967 3 5 22
GSE20123 THRAP3 9967 3 4 23
GSE43470 THRAP3 9967 7 2 34
GSE46452 THRAP3 9967 4 1 54
GSE47630 THRAP3 9967 8 3 29
GSE54993 THRAP3 9967 1 1 68
GSE54994 THRAP3 9967 11 2 40
GSE60625 THRAP3 9967 0 0 11
GSE74703 THRAP3 9967 6 1 29
GSE74704 THRAP3 9967 2 0 18
TCGA THRAP3 9967 11 18 67

Total number of gains: 56; Total number of losses: 37; Total Number of normals: 395.  

 

Somatic mutations of THRAP3:

 

Generating mutation plots.

 

Highly correlated genes for THRAP3:

 

Showing top 20/205 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
THRAP3STK400.801148303
THRAP3ALG60.786365303
THRAP3ZNF518A0.781714303
THRAP3PIGN0.7673303
THRAP3KLHDC100.766843303
THRAP3LRRD10.758891303
THRAP3ANKRD650.752092303
THRAP3PWWP2A0.749531303
THRAP3UBE3B0.746034303
THRAP3ADH1C0.738667303
THRAP3DNAJB120.737202303
THRAP3TAB30.733154303
THRAP3AIFM10.729926303
THRAP3KAT50.728086303
THRAP3C12orf500.727323303
THRAP3SPSB40.725482303
THRAP3ZNF5830.721996303
THRAP3ZNF5280.721472303
THRAP3ATP6V0B0.716886303
THRAP3ZNF5060.710257303

For details and further investigation, click here