| Full name: tight junction protein 3 | Alias Symbol: ZO-3 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 27134 | HGNC ID: HGNC:11829 | Ensembl Gene: ENSG00000105289 | OMIM ID: 612689 |
| Drug and gene relationship at DGIdb | |||
TJP3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of TJP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TJP3 | 27134 | 213412_at | -1.0698 | 0.1051 | |
| GSE20347 | TJP3 | 27134 | 35148_at | -1.3969 | 0.0000 | |
| GSE23400 | TJP3 | 27134 | 213412_at | -0.9795 | 0.0000 | |
| GSE26886 | TJP3 | 27134 | 35148_at | -2.5617 | 0.0000 | |
| GSE29001 | TJP3 | 27134 | 213412_at | -1.2078 | 0.0002 | |
| GSE38129 | TJP3 | 27134 | 35148_at | -1.2921 | 0.0000 | |
| GSE45670 | TJP3 | 27134 | 35148_at | -0.7878 | 0.0326 | |
| GSE53622 | TJP3 | 27134 | 76120 | -0.8816 | 0.0000 | |
| GSE53624 | TJP3 | 27134 | 76120 | -1.6657 | 0.0000 | |
| GSE63941 | TJP3 | 27134 | 35148_at | 0.9834 | 0.1425 | |
| GSE77861 | TJP3 | 27134 | 35148_at | -1.3963 | 0.0011 | |
| GSE97050 | TJP3 | 27134 | A_23_P108157 | 0.4314 | 0.5996 | |
| SRP007169 | TJP3 | 27134 | RNAseq | -4.5540 | 0.0000 | |
| SRP008496 | TJP3 | 27134 | RNAseq | -5.5520 | 0.0000 | |
| SRP064894 | TJP3 | 27134 | RNAseq | -3.2300 | 0.0000 | |
| SRP133303 | TJP3 | 27134 | RNAseq | -2.7576 | 0.0000 | |
| SRP159526 | TJP3 | 27134 | RNAseq | -4.6262 | 0.0000 | |
| SRP193095 | TJP3 | 27134 | RNAseq | -2.3287 | 0.0000 | |
| SRP219564 | TJP3 | 27134 | RNAseq | -2.7627 | 0.0203 | |
| TCGA | TJP3 | 27134 | RNAseq | -1.2487 | 0.0029 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by TJP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TJP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TJP3 | 27134 | 5 | 3 | 22 | |
| GSE20123 | TJP3 | 27134 | 4 | 2 | 24 | |
| GSE43470 | TJP3 | 27134 | 1 | 9 | 33 | |
| GSE46452 | TJP3 | 27134 | 47 | 1 | 11 | |
| GSE47630 | TJP3 | 27134 | 5 | 7 | 28 | |
| GSE54993 | TJP3 | 27134 | 16 | 3 | 51 | |
| GSE54994 | TJP3 | 27134 | 8 | 16 | 29 | |
| GSE60625 | TJP3 | 27134 | 9 | 0 | 2 | |
| GSE74703 | TJP3 | 27134 | 1 | 6 | 29 | |
| GSE74704 | TJP3 | 27134 | 1 | 2 | 17 | |
| TCGA | TJP3 | 27134 | 10 | 19 | 67 |
Total number of gains: 107; Total number of losses: 68; Total Number of normals: 313.
Somatic mutations of TJP3:
Generating mutation plots.
Highly correlated genes for TJP3:
Showing top 20/1507 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TJP3 | SNORA68 | 0.823401 | 4 | 0 | 4 |
| TJP3 | PSCA | 0.813104 | 9 | 0 | 9 |
| TJP3 | PADI1 | 0.795706 | 9 | 0 | 8 |
| TJP3 | BLNK | 0.794588 | 12 | 0 | 12 |
| TJP3 | TIFA | 0.787436 | 6 | 0 | 6 |
| TJP3 | FUT3 | 0.783707 | 13 | 0 | 13 |
| TJP3 | UBL3 | 0.783533 | 10 | 0 | 10 |
| TJP3 | SCNN1B | 0.782836 | 12 | 0 | 12 |
| TJP3 | CLIC3 | 0.781969 | 9 | 0 | 8 |
| TJP3 | CEACAM7 | 0.781482 | 10 | 0 | 10 |
| TJP3 | TTC9 | 0.779945 | 12 | 0 | 10 |
| TJP3 | USP6NL | 0.779119 | 11 | 0 | 11 |
| TJP3 | SASH1 | 0.779007 | 11 | 0 | 10 |
| TJP3 | UPK1A | 0.774921 | 10 | 0 | 9 |
| TJP3 | ESPL1 | 0.774683 | 10 | 0 | 9 |
| TJP3 | SLC13A4 | 0.77249 | 10 | 0 | 10 |
| TJP3 | IL36A | 0.771839 | 10 | 0 | 9 |
| TJP3 | CCNG2 | 0.770979 | 11 | 0 | 10 |
| TJP3 | GDPD3 | 0.770898 | 11 | 0 | 11 |
| TJP3 | FAM95B1 | 0.770296 | 4 | 0 | 4 |
For details and further investigation, click here
