| Full name: integral membrane protein 2B | Alias Symbol: BRI|E25B|E3-16|BRICD2B|BRI2 | ||
| Type: protein-coding gene | Cytoband: 13q14.2 | ||
| Entrez ID: 9445 | HGNC ID: HGNC:6174 | Ensembl Gene: ENSG00000136156 | OMIM ID: 603904 |
Screen Evidence:
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Expression of ITM2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITM2B | 9445 | 217732_s_at | -0.1927 | 0.5030 | |
| GSE20347 | ITM2B | 9445 | 217732_s_at | -0.8143 | 0.0000 | |
| GSE23400 | ITM2B | 9445 | 217732_s_at | -0.2634 | 0.0007 | |
| GSE26886 | ITM2B | 9445 | 217732_s_at | -0.6800 | 0.0013 | |
| GSE29001 | ITM2B | 9445 | 217731_s_at | -0.1470 | 0.4766 | |
| GSE38129 | ITM2B | 9445 | 217732_s_at | -0.5333 | 0.0000 | |
| GSE45670 | ITM2B | 9445 | 217732_s_at | -0.0367 | 0.7651 | |
| GSE53622 | ITM2B | 9445 | 6446 | -0.6148 | 0.0000 | |
| GSE53624 | ITM2B | 9445 | 6446 | -0.5300 | 0.0000 | |
| GSE63941 | ITM2B | 9445 | 217732_s_at | -0.5925 | 0.2079 | |
| GSE77861 | ITM2B | 9445 | 217732_s_at | -0.2770 | 0.2316 | |
| GSE97050 | ITM2B | 9445 | A_33_P3302255 | -0.3886 | 0.3046 | |
| SRP007169 | ITM2B | 9445 | RNAseq | -1.4906 | 0.0003 | |
| SRP008496 | ITM2B | 9445 | RNAseq | -1.2295 | 0.0000 | |
| SRP064894 | ITM2B | 9445 | RNAseq | -0.1357 | 0.4094 | |
| SRP133303 | ITM2B | 9445 | RNAseq | -0.6772 | 0.0000 | |
| SRP159526 | ITM2B | 9445 | RNAseq | -0.9561 | 0.0206 | |
| SRP193095 | ITM2B | 9445 | RNAseq | -0.7114 | 0.0000 | |
| SRP219564 | ITM2B | 9445 | RNAseq | -0.3532 | 0.2028 | |
| TCGA | ITM2B | 9445 | RNAseq | -0.0103 | 0.8382 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ITM2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITM2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITM2B | 9445 | 0 | 13 | 17 | |
| GSE20123 | ITM2B | 9445 | 0 | 12 | 18 | |
| GSE43470 | ITM2B | 9445 | 3 | 13 | 27 | |
| GSE46452 | ITM2B | 9445 | 0 | 32 | 27 | |
| GSE47630 | ITM2B | 9445 | 2 | 27 | 11 | |
| GSE54993 | ITM2B | 9445 | 12 | 2 | 56 | |
| GSE54994 | ITM2B | 9445 | 1 | 17 | 35 | |
| GSE60625 | ITM2B | 9445 | 0 | 3 | 8 | |
| GSE74703 | ITM2B | 9445 | 3 | 10 | 23 | |
| GSE74704 | ITM2B | 9445 | 0 | 9 | 11 | |
| TCGA | ITM2B | 9445 | 7 | 39 | 50 |
Total number of gains: 28; Total number of losses: 177; Total Number of normals: 283.
Somatic mutations of ITM2B:
Generating mutation plots.
Highly correlated genes for ITM2B:
Showing top 20/723 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITM2B | GOLGA4 | 0.725578 | 4 | 0 | 4 |
| ITM2B | SOCS6 | 0.673294 | 3 | 0 | 3 |
| ITM2B | SLC35A4 | 0.662327 | 5 | 0 | 4 |
| ITM2B | ITPR2 | 0.653891 | 5 | 0 | 5 |
| ITM2B | PDCD6IP | 0.653501 | 8 | 0 | 6 |
| ITM2B | ERBB3 | 0.653296 | 5 | 0 | 4 |
| ITM2B | SLC38A9 | 0.648808 | 3 | 0 | 3 |
| ITM2B | BOK | 0.645881 | 5 | 0 | 5 |
| ITM2B | NSG1 | 0.639817 | 6 | 0 | 4 |
| ITM2B | TOM1 | 0.639113 | 7 | 0 | 5 |
| ITM2B | TLCD2 | 0.636722 | 5 | 0 | 3 |
| ITM2B | TVP23B | 0.635461 | 5 | 0 | 4 |
| ITM2B | ALS2CL | 0.634312 | 7 | 0 | 6 |
| ITM2B | ALDH9A1 | 0.630203 | 10 | 0 | 8 |
| ITM2B | OGFRL1 | 0.629796 | 5 | 0 | 5 |
| ITM2B | LIN7C | 0.624554 | 5 | 0 | 4 |
| ITM2B | TMEM220 | 0.624125 | 3 | 0 | 3 |
| ITM2B | METTL7A | 0.623055 | 4 | 0 | 3 |
| ITM2B | HDAC5 | 0.623047 | 5 | 0 | 4 |
| ITM2B | CPEB2 | 0.622925 | 4 | 0 | 3 |
For details and further investigation, click here
