| Full name: TNF receptor superfamily member 21 | Alias Symbol: DR6|CD358 | ||
| Type: protein-coding gene | Cytoband: 6p12.3 | ||
| Entrez ID: 27242 | HGNC ID: HGNC:13469 | Ensembl Gene: ENSG00000146072 | OMIM ID: 605732 |
| Drug and gene relationship at DGIdb | |||
Expression of TNFRSF21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFRSF21 | 27242 | 218856_at | 0.4547 | 0.2544 | |
| GSE20347 | TNFRSF21 | 27242 | 218856_at | -0.2471 | 0.4449 | |
| GSE23400 | TNFRSF21 | 27242 | 218856_at | 0.0825 | 0.5256 | |
| GSE26886 | TNFRSF21 | 27242 | 218856_at | 0.2389 | 0.5563 | |
| GSE29001 | TNFRSF21 | 27242 | 218856_at | -0.1153 | 0.8283 | |
| GSE38129 | TNFRSF21 | 27242 | 218856_at | -0.1106 | 0.6820 | |
| GSE45670 | TNFRSF21 | 27242 | 218856_at | 0.8456 | 0.0101 | |
| GSE53622 | TNFRSF21 | 27242 | 76915 | 0.2826 | 0.0195 | |
| GSE53624 | TNFRSF21 | 27242 | 76915 | -0.0687 | 0.4555 | |
| GSE63941 | TNFRSF21 | 27242 | 218856_at | -2.1875 | 0.0059 | |
| GSE77861 | TNFRSF21 | 27242 | 218856_at | 0.1962 | 0.7345 | |
| GSE97050 | TNFRSF21 | 27242 | A_23_P30666 | 0.8630 | 0.1242 | |
| SRP007169 | TNFRSF21 | 27242 | RNAseq | 0.2097 | 0.6452 | |
| SRP008496 | TNFRSF21 | 27242 | RNAseq | -0.0475 | 0.8835 | |
| SRP064894 | TNFRSF21 | 27242 | RNAseq | 0.1991 | 0.4749 | |
| SRP133303 | TNFRSF21 | 27242 | RNAseq | 0.5054 | 0.0989 | |
| SRP159526 | TNFRSF21 | 27242 | RNAseq | -0.1208 | 0.7543 | |
| SRP193095 | TNFRSF21 | 27242 | RNAseq | 0.0969 | 0.6654 | |
| SRP219564 | TNFRSF21 | 27242 | RNAseq | 0.4825 | 0.3965 | |
| TCGA | TNFRSF21 | 27242 | RNAseq | -0.0411 | 0.6095 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TNFRSF21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFRSF21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFRSF21 | 27242 | 6 | 2 | 22 | |
| GSE20123 | TNFRSF21 | 27242 | 6 | 2 | 22 | |
| GSE43470 | TNFRSF21 | 27242 | 5 | 0 | 38 | |
| GSE46452 | TNFRSF21 | 27242 | 2 | 10 | 47 | |
| GSE47630 | TNFRSF21 | 27242 | 7 | 5 | 28 | |
| GSE54993 | TNFRSF21 | 27242 | 3 | 1 | 66 | |
| GSE54994 | TNFRSF21 | 27242 | 8 | 3 | 42 | |
| GSE60625 | TNFRSF21 | 27242 | 0 | 3 | 8 | |
| GSE74703 | TNFRSF21 | 27242 | 5 | 0 | 31 | |
| GSE74704 | TNFRSF21 | 27242 | 2 | 1 | 17 | |
| TCGA | TNFRSF21 | 27242 | 19 | 14 | 63 |
Total number of gains: 63; Total number of losses: 41; Total Number of normals: 384.
Somatic mutations of TNFRSF21:
Generating mutation plots.
Highly correlated genes for TNFRSF21:
Showing top 20/316 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFRSF21 | PRRC1 | 0.776824 | 3 | 0 | 3 |
| TNFRSF21 | SNRPA1 | 0.758944 | 3 | 0 | 3 |
| TNFRSF21 | RPL26L1 | 0.750245 | 3 | 0 | 3 |
| TNFRSF21 | GGH | 0.747881 | 3 | 0 | 3 |
| TNFRSF21 | CENPE | 0.738197 | 4 | 0 | 4 |
| TNFRSF21 | TMEM123 | 0.734359 | 3 | 0 | 3 |
| TNFRSF21 | SPATA5 | 0.720337 | 3 | 0 | 3 |
| TNFRSF21 | GPR158 | 0.713842 | 3 | 0 | 3 |
| TNFRSF21 | CHST11 | 0.708323 | 4 | 0 | 3 |
| TNFRSF21 | TMEM65 | 0.70684 | 3 | 0 | 3 |
| TNFRSF21 | SLC39A10 | 0.705181 | 3 | 0 | 3 |
| TNFRSF21 | CCDC86 | 0.704987 | 3 | 0 | 3 |
| TNFRSF21 | EXTL3 | 0.704233 | 4 | 0 | 4 |
| TNFRSF21 | OSR2 | 0.70059 | 3 | 0 | 3 |
| TNFRSF21 | OSBPL6 | 0.697971 | 3 | 0 | 3 |
| TNFRSF21 | XRCC4 | 0.697951 | 4 | 0 | 3 |
| TNFRSF21 | FAM167A | 0.696524 | 3 | 0 | 3 |
| TNFRSF21 | C5orf15 | 0.695583 | 4 | 0 | 4 |
| TNFRSF21 | TRIM47 | 0.693564 | 3 | 0 | 3 |
| TNFRSF21 | INTS10 | 0.690563 | 3 | 0 | 3 |
For details and further investigation, click here
