| Full name: transmembrane protein 14B | Alias Symbol: MGC1223 | ||
| Type: protein-coding gene | Cytoband: 6p24.2 | ||
| Entrez ID: 81853 | HGNC ID: HGNC:21384 | Ensembl Gene: ENSG00000137210 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TMEM14B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMEM14B | 81853 | 223133_at | 0.4019 | 0.2706 | |
| GSE20347 | TMEM14B | 81853 | 221452_s_at | 0.1722 | 0.5921 | |
| GSE23400 | TMEM14B | 81853 | 221452_s_at | 0.4598 | 0.0001 | |
| GSE26886 | TMEM14B | 81853 | 223133_at | 0.5253 | 0.0159 | |
| GSE29001 | TMEM14B | 81853 | 221452_s_at | 0.4058 | 0.1345 | |
| GSE38129 | TMEM14B | 81853 | 221452_s_at | 0.1989 | 0.3293 | |
| GSE45670 | TMEM14B | 81853 | 223133_at | -0.0504 | 0.7382 | |
| GSE53622 | TMEM14B | 81853 | 25286 | 0.2292 | 0.0002 | |
| GSE53624 | TMEM14B | 81853 | 25286 | 0.2991 | 0.0000 | |
| GSE63941 | TMEM14B | 81853 | 221452_s_at | 0.3170 | 0.3540 | |
| GSE77861 | TMEM14B | 81853 | 221452_s_at | -0.1014 | 0.7625 | |
| GSE97050 | TMEM14B | 81853 | A_33_P3232047 | 0.1756 | 0.4717 | |
| SRP007169 | TMEM14B | 81853 | RNAseq | -0.3634 | 0.3396 | |
| SRP008496 | TMEM14B | 81853 | RNAseq | -0.2778 | 0.2645 | |
| SRP064894 | TMEM14B | 81853 | RNAseq | 0.0806 | 0.7309 | |
| SRP133303 | TMEM14B | 81853 | RNAseq | 0.1429 | 0.3095 | |
| SRP159526 | TMEM14B | 81853 | RNAseq | 0.5459 | 0.0141 | |
| SRP193095 | TMEM14B | 81853 | RNAseq | -0.3943 | 0.0047 | |
| SRP219564 | TMEM14B | 81853 | RNAseq | -0.2571 | 0.2518 | |
| TCGA | TMEM14B | 81853 | RNAseq | -0.0249 | 0.7382 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TMEM14B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMEM14B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMEM14B | 81853 | 4 | 7 | 19 | |
| GSE20123 | TMEM14B | 81853 | 4 | 7 | 19 | |
| GSE43470 | TMEM14B | 81853 | 8 | 2 | 33 | |
| GSE46452 | TMEM14B | 81853 | 1 | 10 | 48 | |
| GSE47630 | TMEM14B | 81853 | 7 | 8 | 25 | |
| GSE54993 | TMEM14B | 81853 | 1 | 1 | 68 | |
| GSE54994 | TMEM14B | 81853 | 10 | 3 | 40 | |
| GSE60625 | TMEM14B | 81853 | 0 | 1 | 10 | |
| GSE74703 | TMEM14B | 81853 | 7 | 2 | 27 | |
| GSE74704 | TMEM14B | 81853 | 2 | 3 | 15 | |
| TCGA | TMEM14B | 81853 | 15 | 28 | 53 |
Total number of gains: 59; Total number of losses: 72; Total Number of normals: 357.
Somatic mutations of TMEM14B:
Generating mutation plots.
Highly correlated genes for TMEM14B:
Showing top 20/563 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMEM14B | NDUFA12 | 0.776154 | 3 | 0 | 3 |
| TMEM14B | PLCG1 | 0.77328 | 3 | 0 | 3 |
| TMEM14B | YY1 | 0.742012 | 3 | 0 | 3 |
| TMEM14B | DDHD1 | 0.735486 | 3 | 0 | 3 |
| TMEM14B | CCM2 | 0.724842 | 3 | 0 | 3 |
| TMEM14B | ITFG1 | 0.705274 | 4 | 0 | 4 |
| TMEM14B | LRP5L | 0.7023 | 3 | 0 | 3 |
| TMEM14B | PPIG | 0.697899 | 3 | 0 | 3 |
| TMEM14B | CHCHD1 | 0.696613 | 4 | 0 | 4 |
| TMEM14B | NOL7 | 0.696405 | 11 | 0 | 10 |
| TMEM14B | TIFAB | 0.696033 | 3 | 0 | 3 |
| TMEM14B | EIF3L | 0.694554 | 3 | 0 | 3 |
| TMEM14B | ABHD16A | 0.693786 | 3 | 0 | 3 |
| TMEM14B | PAIP2 | 0.691445 | 3 | 0 | 3 |
| TMEM14B | ZNF473 | 0.682465 | 4 | 0 | 3 |
| TMEM14B | TBC1D16 | 0.676577 | 4 | 0 | 3 |
| TMEM14B | RPUSD4 | 0.670082 | 4 | 0 | 3 |
| TMEM14B | SARNP | 0.668372 | 3 | 0 | 3 |
| TMEM14B | NUCKS1 | 0.666346 | 4 | 0 | 3 |
| TMEM14B | SLC31A1 | 0.663029 | 3 | 0 | 3 |
For details and further investigation, click here
