| Full name: leukocyte immunoglobulin like receptor B2 | Alias Symbol: LIR-2|ILT4|MIR-10|LIR2|CD85d|MIR10 | ||
| Type: protein-coding gene | Cytoband: 19q13.4 | ||
| Entrez ID: 10288 | HGNC ID: HGNC:6606 | Ensembl Gene: ENSG00000131042 | OMIM ID: 604815 |
| Drug and gene relationship at DGIdb | |||
LILRB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation |
Expression of LILRB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LILRB2 | 10288 | 207697_x_at | 0.6780 | 0.1693 | |
| GSE20347 | LILRB2 | 10288 | 207697_x_at | 0.1329 | 0.2322 | |
| GSE23400 | LILRB2 | 10288 | 207697_x_at | 0.0766 | 0.0579 | |
| GSE26886 | LILRB2 | 10288 | 207697_x_at | 0.3517 | 0.0518 | |
| GSE29001 | LILRB2 | 10288 | 207697_x_at | 0.2503 | 0.3327 | |
| GSE38129 | LILRB2 | 10288 | 207697_x_at | 0.0392 | 0.8007 | |
| GSE45670 | LILRB2 | 10288 | 207697_x_at | 0.0599 | 0.8137 | |
| GSE53622 | LILRB2 | 10288 | 78221 | 0.7232 | 0.0000 | |
| GSE53624 | LILRB2 | 10288 | 50415 | 1.0327 | 0.0000 | |
| GSE63941 | LILRB2 | 10288 | 207697_x_at | 0.1106 | 0.5340 | |
| GSE77861 | LILRB2 | 10288 | 207697_x_at | 0.1412 | 0.3774 | |
| GSE97050 | LILRB2 | 10288 | A_23_P208493 | 0.9124 | 0.1313 | |
| SRP007169 | LILRB2 | 10288 | RNAseq | 2.8923 | 0.0015 | |
| SRP064894 | LILRB2 | 10288 | RNAseq | 0.8993 | 0.0131 | |
| SRP133303 | LILRB2 | 10288 | RNAseq | 0.7398 | 0.0088 | |
| SRP159526 | LILRB2 | 10288 | RNAseq | 1.2753 | 0.0528 | |
| SRP193095 | LILRB2 | 10288 | RNAseq | 1.4799 | 0.0000 | |
| SRP219564 | LILRB2 | 10288 | RNAseq | 1.3310 | 0.0750 | |
| TCGA | LILRB2 | 10288 | RNAseq | 0.5402 | 0.0033 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by LILRB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LILRB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LILRB2 | 10288 | 3 | 4 | 23 | |
| GSE20123 | LILRB2 | 10288 | 3 | 3 | 24 | |
| GSE43470 | LILRB2 | 10288 | 2 | 11 | 30 | |
| GSE46452 | LILRB2 | 10288 | 45 | 1 | 13 | |
| GSE47630 | LILRB2 | 10288 | 8 | 6 | 26 | |
| GSE54993 | LILRB2 | 10288 | 17 | 4 | 49 | |
| GSE54994 | LILRB2 | 10288 | 4 | 13 | 36 | |
| GSE60625 | LILRB2 | 10288 | 9 | 0 | 2 | |
| GSE74703 | LILRB2 | 10288 | 2 | 7 | 27 | |
| GSE74704 | LILRB2 | 10288 | 3 | 1 | 16 | |
| TCGA | LILRB2 | 10288 | 19 | 15 | 62 |
Total number of gains: 115; Total number of losses: 65; Total Number of normals: 308.
Somatic mutations of LILRB2:
Generating mutation plots.
Highly correlated genes for LILRB2:
Showing top 20/879 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LILRB2 | FCGR3A | 0.831964 | 3 | 0 | 3 |
| LILRB2 | C19orf38 | 0.808232 | 3 | 0 | 3 |
| LILRB2 | MICALCL | 0.774648 | 3 | 0 | 3 |
| LILRB2 | PFN2 | 0.759702 | 3 | 0 | 3 |
| LILRB2 | LRRC8C | 0.757081 | 3 | 0 | 3 |
| LILRB2 | NDUFS6 | 0.749179 | 3 | 0 | 3 |
| LILRB2 | AGTRAP | 0.748601 | 3 | 0 | 3 |
| LILRB2 | HSD3B7 | 0.742398 | 5 | 0 | 5 |
| LILRB2 | CYTH3 | 0.738504 | 3 | 0 | 3 |
| LILRB2 | GALNT10 | 0.724806 | 6 | 0 | 6 |
| LILRB2 | TRMT1 | 0.724609 | 3 | 0 | 3 |
| LILRB2 | CERKL | 0.723903 | 3 | 0 | 3 |
| LILRB2 | CCR1 | 0.722531 | 11 | 0 | 10 |
| LILRB2 | SRRD | 0.720903 | 3 | 0 | 3 |
| LILRB2 | FCER1G | 0.71338 | 10 | 0 | 10 |
| LILRB2 | GPR141 | 0.710455 | 3 | 0 | 3 |
| LILRB2 | TYROBP | 0.708407 | 11 | 0 | 10 |
| LILRB2 | CD14 | 0.706785 | 11 | 0 | 10 |
| LILRB2 | SLC39A3 | 0.703872 | 3 | 0 | 3 |
| LILRB2 | TIFAB | 0.702289 | 4 | 0 | 4 |
For details and further investigation, click here
