| Full name: treacle ribosome biogenesis factor 1 | Alias Symbol: treacle|TCS | ||
| Type: protein-coding gene | Cytoband: 5q32-q33.1 | ||
| Entrez ID: 6949 | HGNC ID: HGNC:11654 | Ensembl Gene: ENSG00000070814 | OMIM ID: 606847 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TCOF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TCOF1 | 6949 | 202384_s_at | 1.0050 | 0.0661 | |
| GSE20347 | TCOF1 | 6949 | 202384_s_at | 0.6638 | 0.0001 | |
| GSE23400 | TCOF1 | 6949 | 202385_s_at | 0.2884 | 0.0000 | |
| GSE26886 | TCOF1 | 6949 | 202385_s_at | 0.8458 | 0.0000 | |
| GSE29001 | TCOF1 | 6949 | 202385_s_at | 0.4546 | 0.0041 | |
| GSE38129 | TCOF1 | 6949 | 202384_s_at | 0.6327 | 0.0000 | |
| GSE45670 | TCOF1 | 6949 | 202385_s_at | 0.7355 | 0.0000 | |
| GSE53622 | TCOF1 | 6949 | 79842 | 0.5968 | 0.0000 | |
| GSE53624 | TCOF1 | 6949 | 50262 | 0.9553 | 0.0000 | |
| GSE63941 | TCOF1 | 6949 | 202385_s_at | 0.6880 | 0.1021 | |
| GSE77861 | TCOF1 | 6949 | 202384_s_at | 0.2231 | 0.2095 | |
| GSE97050 | TCOF1 | 6949 | A_33_P3292915 | 0.6555 | 0.1657 | |
| SRP007169 | TCOF1 | 6949 | RNAseq | 2.9877 | 0.0002 | |
| SRP064894 | TCOF1 | 6949 | RNAseq | 1.2255 | 0.0000 | |
| SRP133303 | TCOF1 | 6949 | RNAseq | 1.0494 | 0.0000 | |
| SRP159526 | TCOF1 | 6949 | RNAseq | 0.7952 | 0.0007 | |
| SRP193095 | TCOF1 | 6949 | RNAseq | 1.2017 | 0.0000 | |
| SRP219564 | TCOF1 | 6949 | RNAseq | 0.8869 | 0.0287 | |
| TCGA | TCOF1 | 6949 | RNAseq | 0.3103 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by TCOF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TCOF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TCOF1 | 6949 | 1 | 12 | 17 | |
| GSE20123 | TCOF1 | 6949 | 1 | 12 | 17 | |
| GSE43470 | TCOF1 | 6949 | 1 | 10 | 32 | |
| GSE46452 | TCOF1 | 6949 | 0 | 27 | 32 | |
| GSE47630 | TCOF1 | 6949 | 0 | 20 | 20 | |
| GSE54993 | TCOF1 | 6949 | 9 | 1 | 60 | |
| GSE54994 | TCOF1 | 6949 | 2 | 15 | 36 | |
| GSE60625 | TCOF1 | 6949 | 0 | 0 | 11 | |
| GSE74703 | TCOF1 | 6949 | 1 | 7 | 28 | |
| GSE74704 | TCOF1 | 6949 | 1 | 7 | 12 | |
| TCGA | TCOF1 | 6949 | 5 | 37 | 54 |
Total number of gains: 21; Total number of losses: 148; Total Number of normals: 319.
Somatic mutations of TCOF1:
Generating mutation plots.
Highly correlated genes for TCOF1:
Showing top 20/1397 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TCOF1 | ALKBH6 | 0.77366 | 3 | 0 | 3 |
| TCOF1 | FBRSL1 | 0.734385 | 3 | 0 | 3 |
| TCOF1 | NPW | 0.72008 | 3 | 0 | 3 |
| TCOF1 | SLC52A2 | 0.702894 | 9 | 0 | 8 |
| TCOF1 | FRMD6-AS1 | 0.699855 | 3 | 0 | 3 |
| TCOF1 | DNMT3B | 0.698392 | 10 | 0 | 9 |
| TCOF1 | ZGRF1 | 0.694106 | 4 | 0 | 4 |
| TCOF1 | MRGBP | 0.693306 | 9 | 0 | 9 |
| TCOF1 | MYBL2 | 0.689657 | 12 | 0 | 11 |
| TCOF1 | CMSS1 | 0.685062 | 6 | 0 | 6 |
| TCOF1 | USB1 | 0.681277 | 10 | 0 | 9 |
| TCOF1 | FMNL2 | 0.680883 | 7 | 0 | 6 |
| TCOF1 | WDR66 | 0.677346 | 7 | 0 | 5 |
| TCOF1 | TTYH3 | 0.676681 | 7 | 0 | 6 |
| TCOF1 | SLC19A1 | 0.675505 | 3 | 0 | 3 |
| TCOF1 | LONP1 | 0.672562 | 10 | 0 | 8 |
| TCOF1 | HOMER3 | 0.670958 | 11 | 0 | 9 |
| TCOF1 | BRAT1 | 0.667242 | 5 | 0 | 4 |
| TCOF1 | TACC3 | 0.666201 | 11 | 0 | 9 |
| TCOF1 | SPC24 | 0.664248 | 5 | 0 | 5 |
For details and further investigation, click here
