| Full name: carbonic anhydrase 3 | Alias Symbol: Car3|CAIII | ||
| Type: protein-coding gene | Cytoband: 8q21.2 | ||
| Entrez ID: 761 | HGNC ID: HGNC:1374 | Ensembl Gene: ENSG00000164879 | OMIM ID: 114750 |
| Drug and gene relationship at DGIdb | |||
Expression of CA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CA3 | 761 | 204865_at | -0.1409 | 0.7089 | |
| GSE20347 | CA3 | 761 | 204865_at | -0.1208 | 0.0189 | |
| GSE23400 | CA3 | 761 | 204865_at | -0.0125 | 0.6722 | |
| GSE26886 | CA3 | 761 | 204865_at | 0.3144 | 0.4955 | |
| GSE29001 | CA3 | 761 | 204865_at | -0.0955 | 0.3485 | |
| GSE38129 | CA3 | 761 | 204865_at | -0.3809 | 0.0536 | |
| GSE45670 | CA3 | 761 | 204865_at | -0.2408 | 0.0377 | |
| GSE53622 | CA3 | 761 | 62884 | -1.9284 | 0.0000 | |
| GSE53624 | CA3 | 761 | 62884 | -2.0090 | 0.0000 | |
| GSE63941 | CA3 | 761 | 204865_at | 0.1553 | 0.2916 | |
| GSE77861 | CA3 | 761 | 204865_at | -0.1117 | 0.1882 | |
| GSE97050 | CA3 | 761 | A_23_P20316 | -1.5486 | 0.2394 | |
| SRP133303 | CA3 | 761 | RNAseq | -2.0102 | 0.0000 | |
| SRP159526 | CA3 | 761 | RNAseq | -0.6529 | 0.4941 | |
| SRP219564 | CA3 | 761 | RNAseq | -1.0237 | 0.1717 | |
| TCGA | CA3 | 761 | RNAseq | -1.8053 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by CA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CA3 | 761 | 13 | 2 | 15 | |
| GSE20123 | CA3 | 761 | 15 | 2 | 13 | |
| GSE43470 | CA3 | 761 | 18 | 1 | 24 | |
| GSE46452 | CA3 | 761 | 21 | 0 | 38 | |
| GSE47630 | CA3 | 761 | 23 | 0 | 17 | |
| GSE54993 | CA3 | 761 | 0 | 19 | 51 | |
| GSE54994 | CA3 | 761 | 32 | 1 | 20 | |
| GSE60625 | CA3 | 761 | 0 | 4 | 7 | |
| GSE74703 | CA3 | 761 | 15 | 1 | 20 | |
| GSE74704 | CA3 | 761 | 10 | 0 | 10 | |
| TCGA | CA3 | 761 | 54 | 2 | 40 |
Total number of gains: 201; Total number of losses: 32; Total Number of normals: 255.
Somatic mutations of CA3:
Generating mutation plots.
Highly correlated genes for CA3:
Showing top 20/345 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CA3 | TNNC1 | 0.730738 | 4 | 0 | 3 |
| CA3 | MAMDC2-AS1 | 0.679225 | 5 | 0 | 5 |
| CA3 | SHROOM3 | 0.659484 | 5 | 0 | 5 |
| CA3 | CMTM2 | 0.656603 | 3 | 0 | 3 |
| CA3 | TRDN | 0.646127 | 4 | 0 | 3 |
| CA3 | CA13 | 0.640183 | 3 | 0 | 3 |
| CA3 | TNXB | 0.638065 | 4 | 0 | 4 |
| CA3 | MYZAP | 0.636793 | 3 | 0 | 3 |
| CA3 | PROM1 | 0.635072 | 4 | 0 | 3 |
| CA3 | KIAA1211L | 0.626568 | 4 | 0 | 4 |
| CA3 | FAM214A | 0.624257 | 4 | 0 | 4 |
| CA3 | EEF1A2 | 0.617016 | 4 | 0 | 3 |
| CA3 | SPNS2 | 0.616463 | 3 | 0 | 3 |
| CA3 | MUC1 | 0.6161 | 6 | 0 | 5 |
| CA3 | ADPRHL1 | 0.608384 | 3 | 0 | 3 |
| CA3 | MTMR10 | 0.605819 | 5 | 0 | 5 |
| CA3 | NPY1R | 0.604023 | 7 | 0 | 4 |
| CA3 | TMPRSS2 | 0.603767 | 4 | 0 | 3 |
| CA3 | ZNRF1 | 0.602959 | 3 | 0 | 3 |
| CA3 | VPS13D | 0.602917 | 6 | 0 | 6 |
For details and further investigation, click here
