TOMM40

 

Full name: translocase of outer mitochondrial membrane 40 Alias Symbol: PEREC1|D19S1177E|C19orf1|TOM40|PER-EC1
Type: protein-coding gene Cytoband: 19q13.32
Entrez ID: 10452 HGNC ID: HGNC:18001 Ensembl Gene: ENSG00000130204 OMIM ID: 608061
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TOMM40 involved pathways:

KEGG pathway Description View
hsa05014Amyotrophic lateral sclerosis (ALS)

 

Expression of TOMM40:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TOMM40 10452 202264_s_at 0.5369 0.1166
GSE20347 TOMM40 10452 202264_s_at 0.3474 0.0100
GSE23400 TOMM40 10452 202264_s_at 0.3821 0.0000
GSE26886 TOMM40 10452 202264_s_at 0.3966 0.0054
GSE29001 TOMM40 10452 202264_s_at 0.1588 0.5599
GSE38129 TOMM40 10452 202264_s_at 0.5641 0.0003
GSE45670 TOMM40 10452 202264_s_at 0.2432 0.0626
GSE63941 TOMM40 10452 202264_s_at 1.1302 0.0024
GSE77861 TOMM40 10452 202264_s_at 0.3137 0.0657
GSE97050 TOMM40 10452 A_24_P15754 0.7371 0.1682
SRP007169 TOMM40 10452 RNAseq 0.4393 0.1390
SRP008496 TOMM40 10452 RNAseq 0.2673 0.1961
SRP064894 TOMM40 10452 RNAseq 0.7058 0.0048
SRP133303 TOMM40 10452 RNAseq 1.2560 0.0000
SRP159526 TOMM40 10452 RNAseq 1.0740 0.0014
SRP193095 TOMM40 10452 RNAseq 0.7029 0.0000
SRP219564 TOMM40 10452 RNAseq 0.7404 0.0477
TCGA TOMM40 10452 RNAseq 0.3135 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by TOMM40 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of TOMM40:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TOMM40 10452 4 5 21
GSE20123 TOMM40 10452 4 4 22
GSE43470 TOMM40 10452 3 11 29
GSE46452 TOMM40 10452 45 1 13
GSE47630 TOMM40 10452 8 6 26
GSE54993 TOMM40 10452 17 4 49
GSE54994 TOMM40 10452 6 12 35
GSE60625 TOMM40 10452 9 0 2
GSE74703 TOMM40 10452 3 7 26
GSE74704 TOMM40 10452 4 2 14
TCGA TOMM40 10452 14 17 65

Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.  

 

Somatic mutations of TOMM40:

 

Generating mutation plots.

 

Highly correlated genes for TOMM40:

 

Showing top 20/980 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TOMM40DPP90.771147303
TOMM40TRADD0.720264303
TOMM40SAMD10.717686404
TOMM40YDJC0.714262505
TOMM40TMC80.709359303
TOMM40UCN20.707334403
TOMM40DHX370.70522303
TOMM40PPP1R14B0.696932707
TOMM40TIGD50.696816505
TOMM40MRPL550.695206403
TOMM40BCAR10.69352404
TOMM40ECE20.692981605
TOMM40RUVBL20.6911821008
TOMM40PNPT10.690554504
TOMM40WNT7B0.675991404
TOMM40WDR740.674174807
TOMM40MYBL20.672237909
TOMM40ATAD3B0.672237504
TOMM40NACC10.670797505
TOMM40SNRPD10.667183806

For details and further investigation, click here