WNT7B

 

Full name: Wnt family member 7B Alias Symbol: 
Type: protein-coding gene Cytoband: 22q13.31
Entrez ID: 7477 HGNC ID: HGNC:12787 Ensembl Gene: ENSG00000188064 OMIM ID: 601967
Drug and gene relationship at DGIdb

 

WNT7B involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05217Basal cell carcinoma

 

Expression of WNT7B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WNT7B 7477 238105_x_at 0.0698 0.8291
GSE20347 WNT7B 7477 217681_at 0.3512 0.0314
GSE23400 WNT7B 7477 217681_at -0.0411 0.3053
GSE26886 WNT7B 7477 238105_x_at 0.6309 0.0006
GSE29001 WNT7B 7477 217681_at 0.0120 0.9370
GSE38129 WNT7B 7477 217681_at 0.3574 0.0107
GSE45670 WNT7B 7477 238105_x_at 0.5360 0.0008
GSE53622 WNT7B 7477 125088 1.3887 0.0000
GSE53624 WNT7B 7477 125088 1.1967 0.0000
GSE63941 WNT7B 7477 238105_x_at 1.0557 0.0138
GSE77861 WNT7B 7477 238105_x_at 0.2939 0.2136
GSE97050 WNT7B 7477 A_33_P3256920 1.6815 0.1731
SRP007169 WNT7B 7477 RNAseq 1.4682 0.0002
SRP008496 WNT7B 7477 RNAseq 1.1672 0.0000
SRP064894 WNT7B 7477 RNAseq 1.6018 0.0001
SRP133303 WNT7B 7477 RNAseq 1.1973 0.0008
SRP159526 WNT7B 7477 RNAseq 1.8657 0.0024
SRP193095 WNT7B 7477 RNAseq 1.5065 0.0000
SRP219564 WNT7B 7477 RNAseq 1.3063 0.1820
TCGA WNT7B 7477 RNAseq 1.8931 0.0000

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by WNT7B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WNT7B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WNT7B 7477 5 6 19
GSE20123 WNT7B 7477 4 5 21
GSE43470 WNT7B 7477 2 6 35
GSE46452 WNT7B 7477 31 2 26
GSE47630 WNT7B 7477 9 4 27
GSE54993 WNT7B 7477 3 6 61
GSE54994 WNT7B 7477 11 7 35
GSE60625 WNT7B 7477 5 0 6
GSE74703 WNT7B 7477 2 4 30
GSE74704 WNT7B 7477 2 3 15
TCGA WNT7B 7477 27 15 54

Total number of gains: 101; Total number of losses: 58; Total Number of normals: 329.  

 

Somatic mutations of WNT7B:

 

Generating mutation plots.

 

Highly correlated genes for WNT7B:

 

Showing top 20/543 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WNT7BKRT170.806774303
WNT7BFIBCD10.779152303
WNT7BPROX10.7139303
WNT7BANO90.713834303
WNT7BRIMS40.688506303
WNT7BTMEM1020.677658404
WNT7BIRX20.676873403
WNT7BTOMM400.675991404
WNT7BIL17F0.671295303
WNT7BRUNX1-IT10.667729303
WNT7BSDC10.661837504
WNT7BLRRC8E0.653479605
WNT7BKRT140.650611806
WNT7BSLC39A30.64854303
WNT7BNACC10.647796303
WNT7BNFKBID0.646712403
WNT7BADRA2C0.638211403
WNT7BWDR660.638072807
WNT7BTTC9B0.635875403
WNT7BGGN0.635779404

For details and further investigation, click here